Controlled and Triggered Small Molecule Release from a Confined Polymer Film

Gao, Yongfeng; Zago, Gustavo Pereira; Jia, Zhanghu; Serpe, Michael J.

doi:10.1021/am4029894

Cited by 46 publications

(66 citation statements)

References 59 publications

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“…Thus, DOX-HCl loaded on superparamagnetic nanoparticles coated with chitosan and employing a folate ligand-activated trigger can improve the system of drug delivery to the cancer cells. The results obtained in this study are in good agreement with the values given in the literature [23].…”

Section: Discussionsupporting

confidence: 92%

“…The saturation magnetization of ZnFe 2 O 4 nanoparticles is higher when synthesized at higher temperatures [18,25]. Hence, the results obtained in this study are in good agreement with the literature [23].…”

Section: Discussionsupporting

confidence: 91%

“…The average particle size in this study was found to be 8.5 nm, which is smaller than the critical size for superparamagnetism (15 nm [23], and 27-30 nm [24]. However, the saturation magnetization of ZnFe 2 O 4 -chitosan-FA-DOX-HCl was found to be 5.6 emu/g.…”

Section: Discussioncontrasting

confidence: 61%

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Preparation of ZnFe2O4–chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics

Esmaeili

Hadad

2015

Ceramics International

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

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Preparation of ZnFe2O4–chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics

Esmaeili

Hadad

2015

Ceramics International

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“…These networks also undergo a swollen-to-collapsed transition in water at elevated temperature. 24 In previous work, we showed that optical devices, known as etalons, could be generated by "sandwiching" a homogeneous monolayer of pNIPAm-co-AAc microgels between two thin Au layers. [21][22][23] Like all temperature induced conformational state changes of pNIPAm, the transition for pNIPAm-based microgels is fully reversible over many cycles.…”

Section: Introductionmentioning

confidence: 99%

“…Specically, pNIPAm-based microgels transition from a swollen (large diameter) to a collapsed (small diameter) state at elevated temperature. 4,[23][24][25][26][27][28][29][30][31][32] The structure of this device can be seen in Fig. PNIPAmbased microgels can also be made responsive to other stimuli, in addition to temperature.…”

Section: Introductionmentioning

confidence: 99%

Controlled release kinetics from a surface modified microgel-based reservoir device

et al. 2015

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A device constructed by sandwiching a thin film of poly(N-isopropylacrylamide)-co-acrylic acid (pNIPAmco-AAc) microgels between two thin layers of Au (all on a glass support) was used as a novel platform for controlled release of small molecules (drugs). In this submission, the model drug tris (4-(dimenthylamino) phenyl)methylium chloride (Crystal Violet, CV) was loaded into the microgel layer of the device by electrostatic interaction of its positive charge with the negative charges on the deprotonated AAc groups on the microgels at pH > 6.5. The upper Au layer of this device was coated with SiO 2 generated by hydrolysis of tetraethyl orthosilicate (TEOS) catalyzed by ammonia at room temperature. Upon exposing the CV loaded devices to pH 3 solutions, the microgel AAc groups were neutralized, and the CV released. The release rate of the CV could be controlled by the thickness of the SiO 2 layer coating the Au layer. Specifically, devices with thick silica layers slow the release rate and thin layers allow for faster release. This device represents an easily fabricated device for controlled and triggered release from a thin film with easily controlled release kinetics.

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Control of Volume‐Responsive Properties of Hydrogels through Molybdenum Disulfide Nanosheet Incorporation

Kim

Lee

2019

Adv Materials Technologies

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efforts have been devoted to remove the aforementioned limitations of the PNIPAM hydrogel sensors by incorporating nanomaterials. [17,18] Recently, low dimensional nanomaterials with a large specific surface area such as carbon nanotubes and graphene oxide have been incorporated to hydrophilic polymers such as PNIPAM, chitosan, and polyacrylic acid hydrogels to enhance the adsorption of substances and chemical storage capacity. [19][20][21] In this study, we demonstrate a composite hydrogel of MoS 2 nanosheets functionalized with 4-mercaptobenzoic acid (MBA) and PNIPAM (MBAMS-PNIPAM hydrogel) for the detection of water-soluble phenols. Herein, MoS 2 nanosheets have been shown to be promising candidate components for various fields, such as the detection of water-soluble substances, humidity, and gas species. [22][23][24][25][26] MBAMS was prepared via MoS 2 exfoliation processes and subsequent chemical functionalization process with 4-MBA for realizing the reactivity and selectivity toward the target substance. Here, 4-MBA, a small ligand molecule with a thiol and a carboxyl group, was used to modify the surface of MoS 2 nanosheets. We also verified that we can adjust the phenol detection range by controlling the adsorption and responsivity of the MBAMS-PNIPAM hydrogel through the amount of the incorporated MoS 2 . In addition, we demonstrate an in situ detection strategy of watersoluble phenols by developing an effective transduction strategy to convert the hydrogel volume change into electronic signals. The novel transduction strategy uses a liquid metal-based capacitive transduction method. Furthermore, combined with a handheld signal processor and home-built data-visualization software, we demonstrate a portable detection instrument for phenolic molecules. The instrument successfully detected resorcinol concentrations as low as 10 mg L −1 . As an example, compared to other sensors using optical or electrical mechanisms, [27][28][29] our hydrogel can be readily integrated with existing ducts, containers, or pipe systems without any additional process. Furthermore, above certain concentrations, the hydrogel color change will be large enough to enable detection with the naked eye. As this strategy enables the simple, one-step, and easy detection, it can be easily extended to detect water-soluble chemicals other than phenols in the future. Figure 1a depicts the molecular structure of MBAMS-PNIPAM hydrogels and the detection mechanism of phenols. The surface of MoS 2 was functionalized with 4-MBA molecules to enhance the reactivity and selectivity toward the target phenolic substance and stabilize the hydrogel structure. The target phenolic molecule A composite structure of molybdenum disulfide (MoS 2 ) nanosheets and poly(N-isopropylacrylamide) (PNIPAM) hydrogel is demonstrated for the selective detection of phenols. The incorporation of MoS 2 with a hydrogel system enhances its adsorption and its volume-change response to phenols. It is verified that the phenol detection range can be adjusted by controlling the ...

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Controlled and Triggered Small Molecule Release from a Confined Polymer Film

Cited by 46 publications

References 59 publications

Preparation of ZnFe2O4–chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics

Preparation of ZnFe2O4–chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics

Controlled release kinetics from a surface modified microgel-based reservoir device

Control of Volume‐Responsive Properties of Hydrogels through Molybdenum Disulfide Nanosheet Incorporation

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