Controlled assembly of dendrimer-like DNA

Li, Yougen; Tseng, Yolanda D.; Kwon, Sang Yeon; d'Espaux, Leo; Bunch, J. Scott; McEuen, Paul L.; Luo, Dan

doi:10.1038/nmat1045

Cited by 436 publications

(306 citation statements)

References 29 publications

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“…New soft-matter systems in which valence can be precisely controlled, e.g., DNA constructs [5,59] and new polymers [60], may contribute to deepening our understanding of fundamental problems in disordered systems. Providing valence to colloids [4,61] is opening a very rich line of investigation.…”

Section: Discussionmentioning

confidence: 99%

Understanding tetrahedral liquids through patchy colloids

Saika‐Voivod

Smallenburg

Sciortino

2013

The Journal of Chemical Physics

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We investigate the structural properties of a simple model for tetrahedral patchy colloids in which the patch width and the patch range can be tuned independently. For wide bond angles, a fully bonded network can be generated by standard Monte Carlo or molecular dynamics simulations of the model, providing a neat method for generating defect-free random tetrahedral networks. This offers the possibility of focusing on the role of the patch angular width on the structure of the fully bonded network. The analysis of the fully bonded configurations as a function of the bonding angle shows how the bonding angle controls the system compressibility, the strength of the pre-peak in the structure factor and ring size distribution. Comparison with models of liquid water and silica allows us to find the best mapping between these continuous potentials and the colloidal one. Building on previous studies focused on the connection between angular range and crystallization, the mapping makes it possible to shed new light on the glass-forming ability of network-forming tetrahedral liquids.

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Section: Discussionmentioning

confidence: 99%

Understanding tetrahedral liquids through patchy colloids

Saika‐Voivod

Smallenburg

Sciortino

2013

The Journal of Chemical Physics

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“…Although the one-bond-per-patch limitations renders this model inadequate for colloidal particles with large attractive surface regions, we stress here that the model mimics systems with a limited-valence bonding mechanism that retains a large degree of bonding flexibility for all experimentally relevant temperature scales. For example, one might consider colloidal particles functionalized with a limited number (f ) of long strands of DNA (refs 12,16), DNA constructs that can form a fixed number of bonds 14,17 , or even polymer networks 18 where the particles are polymerizable monomers with a fixed functionality.…”

mentioning

confidence: 99%

Liquids more stable than crystals in particles with limited valence and flexible bonds

2013

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All liquids (except helium owing to quantum effects) crystallize at low temperatures, forming ordered structures. The competition between disorder, which stabilizes the liquid phase, and energy, which leads to a preference for the crystalline structure, inevitably favours the crystal when the temperature is lowered and entropy becomes progressively less relevant. The liquid state survives at low temperatures only as a glass, an out-of-equilibrium arrested state of matter. This textbook description holds inevitably for atomic and molecular systems, where particle interactions are set by quantum-mechanical laws. The question remains whether it holds for colloidal particles, where interparticle interactions are usually short-ranged and tunable. Here we show that for patchy colloids with limited valence 1 , conditions can be found for which the liquid phase is stable even in the zero-temperature limit. Our results offer fresh cues for understanding the stability of gels 2 and the glass-forming ability of molecular network glasses 3,4 .The ability to control the selectivity and angular flexibility of interparticle interactions 5 makes it possible to provide valence to colloids. This can be done by means of chemical [6][7][8] or physical 9 patterning of the colloid surface, that is, locally changing either its chemical properties (for example, hydrophobicity), or the physical properties (for example, roughness). Exploiting valence offers enormous possibilities, some of which have been addressed in recent years, theoretically 10 , numerically 4,11,12 and experimentally 2,7,13,14 . As colloidal interactions are typically shortranged, valence provides an implicit quantization of the particle energy, which becomes essentially proportional to the (limited) number of formed bonds. In an optimal arrangement, all particles bind with their maximum number of neighbours and the system is in its lowest possible (ground) energy state. Typically, such an optimal arrangement is spatially ordered, defining the most stable crystal phase(s).In principle, when the density is not too high, it is possible to imagine disordered arrangements in which all particles are fully bonded, with exactly the same energy as the crystal. Such a state, which was recently shown to be stable in a model system for DNA-functionalized colloids 12 , is a liquid: a fluid, disordered phase at temperatures below the critical temperature. Under this unconventional condition, the stability of the system becomes controlled by its entropy, a case reminiscent of (purely entropydriven) hard-sphere particles. In this study we demonstrate that the flexibility of the bonds (encoded in the angular patch width)-a tunable quantity in the design of patchy colloidal particles-is the key element in controlling the entropy of the liquid as compared with that of the crystal. Large binding angles combined with limited valence give rise to a thermodynamically stable, fully bonded liquid phase.Department of Physics, Sapienza, Universitá di Roma, Piazzale Aldo Moro 2, I-00185, Roma,...

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“…They are polymeric molecules made up of multiple perfectly branched monomers that capable of self organization property and emanate radially from a central core 25,26 .…”

Section: Dendrimersmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:Over the past few decades, the pursuit and exploration of nanotechnology is likely to have a significant impact on the drugdelivery system. This technology can be envisioned as playing a major role in revolutionizing the future of novel drug delivery system. Nanoparticles (NPs) are one of them which have many potential applications in clinical medicine and research. The encapsulation of therapeutic drugs in the form of nanoparticles shows advantageous effect over their corresponding drugs such as increases drug efficacy, specificity, tolerability and therapeutic index. The current review article focuses on the different nanoparticulate drug-delivery systems including nanoerythrosomes, Superparamagnetic nanoparticles, liposomes, Quantum dots, ceramic nanoparticles and dendrimers as well as their applications in different field.

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Controlled assembly of dendrimer-like DNA

Cited by 436 publications

References 29 publications

Understanding tetrahedral liquids through patchy colloids

Understanding tetrahedral liquids through patchy colloids

Liquids more stable than crystals in particles with limited valence and flexible bonds

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