Controlled cisplatin delivery system using poly(d,l-lactic acid]

Ike, Osamu; Shimizu, Yoichi; Wada, Ryoichi; Hyon, Suong Hyu; Ikada, Yoshito

doi:10.1016/0142-9612(92)90189-u

Cited by 47 publications

(24 citation statements)

References 13 publications

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“…Long-term delivery of atRA would improve the chemopreventive effect of atRA in cancer treatment. Microspheres have been proven to be efficient systems for delivery of a wide range of chemotherapeutics (Ike et al 1992;Menei et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Formulation andin-vitrocharacterization of retinoic acid loaded poly (lactic-co-glycolic acid) microspheres

Çirpanli

Ünlü

Çalış

et al. 2005

Journal of Microencapsulation

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Poly (lactic-co-glycolic acid) (PLGA) microspheres containing all-trans retinoic acid (atRA) were prepared by emulsion/solvent evaporation technique. PLGA (50:50) with inherent viscosities of 0.17 and 0.39 dL g(-1) was used. Polyvinyl alcohol (PVA) or PVA and sodium oleate (SO) combinations (4:1) were used to stabilize the emulsions. The effect of polymer viscosity, emulsifier type and concentration on the in vitro release of atRA from the microspheres was investigated. The stability of the microparticles was also tested at the temperatures of 4, 25 and 40 degrees C. The particle size ranged between 1-2 microm. Microspheres were smooth and spherical in shape, as determined by scanning electron microscope (SEM) photographs. The yield of microspheres ranged from 50-75% and the encapsulation efficiency was determined between 45-75%. In vitro release studies showed that atRA release from microspheres lasted for 11 days.

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Section: Introductionmentioning

confidence: 99%

Formulation andin-vitrocharacterization of retinoic acid loaded poly (lactic-co-glycolic acid) microspheres

Çirpanli

Ünlü

Çalış

et al. 2005

Journal of Microencapsulation

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“…A slight increase in inflammatory and foreign body responses were observed for cisplatin-loaded microspheres compared with cisplatin-free microspheres. 11 These studies pointed out the importance of carrying out control studies using delivery system without active agent. 9 Therefore, insulin-loaded PLGA microspheres were investigated for in vitro insulin release, in vivo basal insulin delivery and biocompatibility in rabbits.…”

Section: Introductionmentioning

confidence: 99%

Preparation, in vitro release, in vivo absorption and biocompatibility studies of insulin-loaded microspheres in rabbits

Kang

Singh

2005

AAPS PharmSciTech

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The purpose of this study was to develop a single-dose insulin delivery system based on poly (lactide-co-glycolide) (PLGA) microspheres to provide basal insulin level for a prolonged period. Insulin-loaded PLGA microspheres were prepared by water-in-oil-in-water double emulsion (batch A) and solid-in-oil-in-water emulsion (batch B) methods. Microspheres were characterized for physical characteristics and in vitro release. In vivo absorption of insulin and biocompatibility of insulin-loaded PLGA microspheres were performed in diabetic New Zealand white rabbits. Light and transmission electron microscopy were performed on the skin tissues excised from microspheres injected sites in order to study the biocompatibility. The burst release of insulin was high (47%) from batch B and low (5%) from batch A. Therefore, we mixed microspheres of batch A and B in ratio of 3:1 w/w, which produced desirable in vitro release profile. In vivo absorption study showed that insulin-loaded microspheres provided a serum insulin level of 20-40 μU/ml up to 40 days. Biocompatibility study provided evidence of normal inflammatory and foreign body reactions, which were characterized by the presence of macrophages, fibroblasts and foreign body giant cells. Neither necrosis nor tissue damage was identified. At the end of 12 weeks, no distinct histological differences were observed in comparison to the control tissue samples. In conclusion, insulin-loaded PLGA microspheres controlled the in vivo absorption of insulin to maintain the basal insulin level for longer period and the delivery system was biocompatible.

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“…Microspheres containing antitumoral agents have been already prepared, [19][20][21][25][26][27] but little work has been done on the encapsulation of anticancer drugs in polyesters by the spray-drying technique, 19,28 because solvent evaporation is the method commonly used. 29,30 The spray-drying process received great attention for the preparation of microparticulate controlled release systems, 31,32 because it is a 1-step process and involves, simply, the preparation of a solution of drug and polymer.…”

Section: Introductionmentioning

confidence: 99%

Spray-dried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: In vitro and in vivo studies

et al. 2005

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The aim of this study was the development of a veterinary dosage form constituted by injectable biodegradable microspheres designed for the subcutaneous release of carboplatin, a chemotherapeutic drug. Poly(D,L-lactide) (PDLLA) microspheres were prepared by an emulsification/spray-drying method, using the drug-to-polymer weight ratios 1:9 and 1:5; blank microspheres (1% w/v) were prepared as a comparison. Microparticles were characterized in terms of morphology, encapsulation efficiency, and in vitro drug release behavior. In vivo tests were conducted on rats by subcutaneous injection of microsphere aqueous suspensions. Levels of carboplatin were evaluated both in the skin and in serum. The microparticles obtained had a spherical shape; particle size ranged from 5 to 7 mm, dependent on drug loading. Microspheres were able to control the in vitro release of the drug: approximately 90% to 100% of the carboplatin was released over 30 days. In vivo results showed that the microspheres were able to release high drug amounts locally, and sustained serum levels of drug were also achieved. Based on these results, carboplatin-loaded PDLLA microspheres may be useful for local delivery of the antineoplastic drug to the tumor, avoiding tumor recurrence in small animals, and may decrease the formation of distant metastases.

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Controlled cisplatin delivery system using poly(d,l-lactic acid]

Cited by 47 publications

References 13 publications

Formulation andin-vitrocharacterization of retinoic acid loaded poly (lactic-co-glycolic acid) microspheres

Formulation andin-vitrocharacterization of retinoic acid loaded poly (lactic-co-glycolic acid) microspheres

Preparation, in vitro release, in vivo absorption and biocompatibility studies of insulin-loaded microspheres in rabbits

Spray-dried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: In vitro and in vivo studies

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