Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance

Nieto-Bobadilla, M.S.; Siepmann, Florence; Djouina, Madjid; Dubuquoy, Laurent; Tesse, Nicolas; willart, Jean-François; Dubreuil, L.; Siepmann, Juergen; Neut, Christel

doi:10.1016/j.ejpb.2015.07.012

Cited by 12 publications

(16 citation statements)

References 41 publications

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“…The intestinal bacterial mibrobiota contributes to the luminal biological barrier and interacts with the host, thereby affecting the health status of the host [ 16 ]. Intestinal diseases are often associated with the changes in enteric bacterial microbiota, such as the increased proliferation of harmful bacteria and the decreased proliferation of beneficial bacteria [ 17 ]. In the present study, pigs fed OCM diet exhibited an increase in the populations of Enterococcus genus and Lactobacillus genus, but a reduction in the abundance of Enterobacteriaceae family, Clostridium coccoides and Bifidobacterium genus in the caecum digesta ( Figure 1 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets

Fang

Hou

Wang

et al. 2018

IJMS

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The present study was to determine the efficacy of dietary supplementation with oleum cinnamomi (OCM) on growth performance and intestinal functions in piglets. Sixteen piglets (24-day-old) were randomly assigned to the control or OCM groups. Piglets in the control group were fed a basal diet, whereas piglets in the OCM group were fed the basal diet supplemented with 50 mg/kg OCM. On day 20 of the trial, blood samples and intestinal tissues were obtained from piglets. Compared with the control group, dietary OCM supplementation increased (p < 0.05) average daily feed intake, plasma insulin levels, villus width and villous surface area in the duodenum and jejunum, DNA levels and RNA/DNA ratios in the ileum, the abundance of Enterococcus genus and Lactobacillus genus in caecum digesta, mRNA levels for epithelial growth factor receptor (EGFR), Ras, extracellular signal-regulated kinase 1/2 (Erk1/2), b-cell lymphoma-extra large (Bcl-xL), villin, junctional adhesion molecule A (JAM-A), myxovirus resistance (MX) 1, MX2 and regenerating islet-derived protein 3 gamma (REG3G), and protein abundances of Ras and claudin-1, but decreased (p < 0.05) diarrhoea incidence; the abundances of Enterobacteriaceae family, Enterococcus genus, Lactobacillus genus, Bifidobacterium genus, and Clostrium coccoides in the colon digesta, and AMP-activated protein kinase (AMPK) mRNA levels and caspase-3 protein abundance in the jejunal mucosa of piglets. Taken together, these data indicate that dietary OCM supplementation modulates intestinal microbiota and improves intestinal function in weanling pigs. OCM is an effective feed additive and alternative to feed antibiotics for improving intestinal health in swine.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets

Fang

Hou

Wang

et al. 2018

IJMS

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“…Studies suggest that antibiotics therapy with the combined dose of ampicillin, metronidazole, neomycin and vancomycin, or bacitracin and neomycin, increases bacterial translocation, induces mild inflammation and the risk of developing DSS‐induced colitis 65 , 66 . However, different studies using CIN‐102, a natural cinnamon oil composition‐like mixture with broad‐spectrum antibacterial activity, and cathelicidin from Bungarus fasciatus decreased intestinal bacterial load, and improved symptoms of DSS‐induced colitis 67 , 68 . Ciprofloxacin and metronidazole have also been shown to reduce ileitis in genetically modified mice through the downregulation of pro‐inflammatory cytokines IFN‐γ and TNF, and T‐cell activation 69 .…”

Section: The Local Effects Of Gut Microbiota On Ibdmentioning

confidence: 99%

“…These highlight the importance in choosing the right antibacterial compounds and combinations of antibiotics are crucial to the control of disease. Furthermore, with the natural antibacterial therapy having shown no resistance in the study, it may have advantages over conventional antibiotics in its spectrum of control of the gut microbiota 67 . Antibiotics can change the outcome of colitis even when given antepartum.…”

Section: The Local Effects Of Gut Microbiota On Ibdmentioning

confidence: 99%

“…65,66 However, different studies using CIN-102, a natural cinnamon oil composition-like mixture with broad-spectrum antibacterial activity, and cathelicidin from Bungarus fasciatus decreased intestinal bacterial load, and improved symptoms of DSS-induced colitis. 67,68 Ciprofloxacin and metronidazole have also been shown to reduce ileitis in genetically modified mice through the downregulation of pro-inflammatory cytokines IFN-γ and TNF, and T-cell activation. 69 Although some antibiotics such as ampicillin and ciprofloxacin have broad-spectrum activities, others have specific activities, with vancomycin targeting Gram-positive bacteria, and metronidazole targeting anaerobes.…”

Section: The Local Effects Of Gut Microbiota On Ibdmentioning

confidence: 99%

“…Furthermore, with the natural antibacterial therapy having shown no resistance in the study, it may have advantages over conventional antibiotics in its spectrum of control of the gut microbiota. 67 Antibiotics can change the outcome of colitis even when given antepartum. The use of antibiotics during pregnancy also decreases bacterial richness and increases the risk of colitis for the offspring.…”

Section: The Local Effects Of Gut Microbiota On Ibdmentioning

confidence: 99%

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Bugging inflammation: role of the gut microbiota

Shen

Wong

2016

Clin & Trans Imm

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The advent of vaccination and improved hygiene have eliminated many of the deadly infectious pathogens in developed nations. However, the incidences of inflammatory diseases, such as inflammatory bowel disease, asthma, obesity and diabetes are increasing dramatically. Research in the recent decades revealed that it is indeed the lack of early childhood microbial exposure, increase use of antibiotics, as well as increase consumption of processed foods high in carbohydrates and fats, and lacking fibre, which wreak havoc on the proper development of immunity and predispose the host to elevated inflammatory conditions. Although largely unexplored and under-appreciated until recent years, these factors impact significantly on the composition of the gut microbiota (a collection of microorganisms that live within the host mucosal tissue) and inadvertently play intricate and pivotal roles in modulating an appropriate host immune response. The suggestion that shifts in the composition of host microbiota is a risk factor for inflammatory disease raises an exciting opportunity whereby the microbiota may also present as a potential modifiable component or therapeutic target for inflammatory diseases. This review provides insights into the interactions between the microbiota and the immune system, how these affect disease phenotypes, and explore current and emerging therapies that target the gut microbiota as potential treatment for inflammatory diseases.

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A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β‐caryophyllene

Rahimi

Askari

2022

BioFactors

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β-Caryophyllene (BCP) is a plant-derived compound and occurs naturally in various foods and spices, including cinnamon, citrus, fruits, clove, curry, and pepper. BCP showed different pharmacological effects, such as antioxidant and antimicrobial properties. This article tried to gather updated knowledge of the anti-inflammatory, antioxidant, and immunomodulatory effects of BCP and searched using various databases and appropriate keywords until April 2022. Several studies showed that the anti-inflammatory effects of BCP are mainly provided through cannabinoid receptor 2 (CB 2 ) receptor activation and the peroxisome proliferator-activated receptor (PPAR) γ pathway. It has also been demonstrated that BCP suppresses both protein and mRNA expression levels of interleukin (IL)-6 and reduces relevant proinflammatory cytokines but increases the anti-inflammatory cytokine IL-13. Previous results indicated that the antioxidant effects of β-caryophyllene were suggested through different pathways, including activation of nuclear factor erythroid 2-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1)/antioxidant axis and inhibition of the HMG-CoA reductase activity, and oxidative stress biomarkers levels. Furthermore, various results showed immunomodulatory effects of BCP through inhibiting microglial cells, CD 4+ and CD 8+ T lymphocytes, modulated Th 1 /T reg immune balance through the activation of the CB 2 receptor, and reducing mitogenactivated protein kinases (p38MAPK) and NF-kB activation and increased ionized calcium-binding adaptor molecule-1 (Iba-1) and IL-1β.

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Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance

Cited by 12 publications

References 41 publications

Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets

Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets

Bugging inflammation: role of the gut microbiota

A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β‐caryophyllene

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