Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation

Dong, Xiaoxiao; Lu, Xiaofang; Kingston, Kailee; Brewer, E. Cobham; Juliar, Benjamin A.; Kripfgans, Oliver D.; Fowlkes, J. Brian; Franceschi, Renny T.; Putnam, Andrew J.; Liu, Zheng; Fabiilli, Mario L.

doi:10.1016/j.actbio.2019.08.016

Cited by 35 publications

(25 citation statements)

References 51 publications

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“…The release of molecules from the scaffold can be controlled by modifying the properties and composition of the material, TABLE 1 | List of common bioactive molecules used in tissue engineering vascularization and mentioned in this review. Lee et al, 2001;Gerhardt et al, 2003;Chiu and Radisic, 2010;Chow et al, 2010;Yuen et al, 2010;Shah et al, 2011;Zheng et al, 2012;Brudno et al, 2013;Nguyen et al, 2013;Alsop et al, 2014;Lai et al, 2014;Rich et al, 2014;Stamati et al, 2014;Wu et al, 2016;LaValley et al, 2017;Turner et al, 2017;Kuttappan et al, 2018;Stejskalová et al, 2019;Wang et al, 2019FGF Chow et al, 2010Tengood et al, 2011;Lai et al, 2014;Stamati et al, 2014;Kuttappan et al, 2018;Dong et al, 2019IGF Holland et al, 2005EGF Lai et al, 2014PDGF Tengood et al, 2011Brudno et al, 2013;Lai et al, 2014;Stejskalová et al, 2019;Wang et al, 2019Glycosaminoglycans Chow et al, 2010Chow et al, 2014;Wu et al, 2016 Frontiers in Bioengineering and Biotechnology | www.frontiersin.org as well as changing the method of retaining the drug (King and Krebsbach, 2012). Boontheekul et a...…”

Section: Degradation Dependent Releasementioning

confidence: 99%

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Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo

Cathery

Velliou

et al. 2020

Front. Bioeng. Biotechnol.

140

109

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Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack of mature and functional vasculature greatly limits the size and complexity of vascular scaffold models. If tissue engineering aims to replace large portions of tissue with the intention of repairing significant defects, a more thorough understanding of the mechanisms and players regulating the angiogenic process is required in the field. This review will present the current material and technological advancements addressing the imperfect formation of mature blood vessels within tissue engineered structures.

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Section: Degradation Dependent Releasementioning

confidence: 99%

“…Acoustic waves can be used to release molecules from acoustically responsive scaffolds (ARSs) (Dong et al, 2019). Dong et al developed a bFGF functionalized ARS that released GFs upon ultrasound-mediated triggering of acoustic droplet vaporization.…”

Section: Mechanical Releasementioning

confidence: 99%

Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo

Cathery

Velliou

et al. 2020

Front. Bioeng. Biotechnol.

140

109

View full text Add to dashboard Cite

show abstract

“…Alternatively, ultrasound-induced drug release has been achieved by destabilizing encapsulating agents with acoustic droplet vaporization (ADV) mechanisms, which mediate their transition from liquid to gas phase in response to pressure induced by acoustic stimuli. In this regard, Dong and colleagues developed an acoustically responsive hydrogel consisting of sonosensitive micron-sized emulsions embedded within a fibrin matrix which, under 2.5 MHz sound waves, released encapsulated basic fibroblast growth factor (bFGF) [ 58 ]. The emulsion entails a water-in-perfluorocarbon (PFC)-in-water (W 1 /PFC/W 2 ) double emulsion, with bFGF in the W 1 phase, and its release occurs when PFC within each droplet phase transitions from liquid to gas, thereby disrupting the droplet morphology.…”

Section: Stimuli-responsive Decm-based Hydrogels For the Delivery Of Therapeuticsmentioning

confidence: 99%

Recent Advances on Stimuli-Responsive Hydrogels Based on Tissue-Derived ECMs and Their Components: Towards Improving Functionality for Tissue Engineering and Controlled Drug Delivery

et al. 2021

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Due to their highly hydrophilic nature and compositional versatility, hydrogels have assumed a protagonic role in the development of physiologically relevant tissues for several biomedical applications, such as in vivo tissue replacement or regeneration and in vitro disease modeling. By forming interconnected polymeric networks, hydrogels can be loaded with therapeutic agents, small molecules, or cells to deliver them locally to specific tissues or act as scaffolds for hosting cellular development. Hydrogels derived from decellularized extracellular matrices (dECMs), in particular, have gained significant attention in the fields of tissue engineering and regenerative medicine due to their inherently high biomimetic capabilities and endowment of a wide variety of bioactive cues capable of directing cellular behavior. However, these hydrogels often exhibit poor mechanical stability, and their biological properties alone are not enough to direct the development of tissue constructs with functional phenotypes. This review highlights the different ways in which external stimuli (e.g., light, thermal, mechanical, electric, magnetic, and acoustic) have been employed to improve the performance of dECM-based hydrogels for tissue engineering and regenerative medicine applications. Specifically, we outline how these stimuli have been implemented to improve their mechanical stability, tune their microarchitectural characteristics, facilitate tissue morphogenesis and enable precise control of drug release profiles. The strategic coupling of the bioactive features of dECM-based hydrogels with these stimulation schemes grants considerable advances in the development of functional hydrogels for a wide variety of applications within these fields.

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“…With this technique, growth factors are encapsulated into acoustically responsive droplets (<10 μm) which are then embedded in fibrin-based hydrogels. Exposing fibrin-embedded, basic fibroblast growth factor (bFGF)-loaded droplets to ultrasound triggered growth factor release into the surrounding media, and treatment of endothelial cells with this conditioned media enhanced cell viability [ 98 ] and vascular sprout formation [ 143 ]. Additionally, ultrasound-induced cavitation increased the porosity and stiffness of these fibrin scaffolds [ 98 ].…”

Section: Acoustic Manipulation Of Ecm-based Scaffoldsmentioning

confidence: 99%

Using Acoustic Fields to Fabricate ECM-Based Biomaterials for Regenerative Medicine Applications

Norris

Dalecki

Hocking

2020

RPM

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Ultrasound is emerging as a promising tool for both characterizing and fabricating engineered biomaterials. Ultrasound-based technologies offer a diverse toolbox with outstanding capacity for optimization and customization within a variety of therapeutic contexts, including improved extracellular matrix-based materials for regenerative medicine applications. Non-invasive ultrasound fabrication tools include the use of thermal and mechanical effects of acoustic waves to modify the structure and function of extracellular matrix scaffolds both directly, and indirectly via biochemical and cellular mediators. Materials derived from components of native extracellular matrix are an essential component of engineered biomaterials designed to stimulate cell and tissue functions and repair or replace injured tissues. Thus, continued investigations into biological and acoustic mechanisms by which ultrasound can be used to manipulate extracellular matrix components within three-dimensional hydrogels hold much potential to enable the production of improved biomaterials for clinical and research applications.

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Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation

Cited by 35 publications

References 51 publications

Angiogenesis in Tissue Engineering: As Nature Intended?

Angiogenesis in Tissue Engineering: As Nature Intended?

Recent Advances on Stimuli-Responsive Hydrogels Based on Tissue-Derived ECMs and Their Components: Towards Improving Functionality for Tissue Engineering and Controlled Drug Delivery

Using Acoustic Fields to Fabricate ECM-Based Biomaterials for Regenerative Medicine Applications

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