Controlled deposition of electrospun poly(ethylene oxide) fibers

Deitzel, Joseph M.; Kleinmeyer, James D.; Hirvonen, James K.

doi:10.1016/s0032-3861(01)00336-6

Cited by 793 publications

(436 citation statements)

References 10 publications

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“…The crystallinity degree of ES fibres appears to be lower than that of the "as received" sample. This result is not surprising since the fast ES process is expected to limit crystal formation [60,61] or even to totally inhibit crystallization, as above reported in the case of P(L)LA. …”

Section: Poly(ε-caprolactone)supporting

confidence: 75%

“…Aliphatic polycarbonates are also applied in tissue engineering [61], in particular poly(1,3-trimethylene carbonate) (PTMC), an elastomeric polymer potentially candidate for soft tissue engineering. Trimethylene carbonate is also widely used as co-monomer with lactic acid, glicolic acid or ε-caprolactone in order to obtain scaffolds with elastomeric properties [62][63][64][65][66].…”

Section: Biomaterialsmentioning

confidence: 99%

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Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering

Gualandi

2011

Springer Theses

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and some lactide copolymers) and of non-commercial polyesters (i.e. poly-ω-pentadecalactone and some of its copolymers) were explored and discussed.Two techniques were employed to fabricate scaffolds: supercritical carbon dioxide (scCO 2 ) foaming and electrospinning (ES). The former is a powerful technology that enables to produce 3D microporous foams by avoiding the use of solvents that can be toxic to mammalian cells. The scCO 2 process, which is II commonly applied to amorphous polymers, was successfully modified to foam a highly crystalline poly(ω-pentadecalactone-co-ε-caprolactone) copolymer and the effect of process parameters on scaffold morphology and thermo-mechanical properties was investigated.In the course of the present research activity, sub-micrometric fibrous nonwoven meshes were produced using ES technology. Electrospun materials are considered highly promising scaffolds because they resemble the 3D organization of native extra cellular matrix. A careful control of process parameters allowed to fabricate defect-free fibres with diameters ranging from hundreds of nanometers to several microns, having either smooth or porous surface. Moreover, versatility of ES technology enabled to produce electrospun scaffolds from different polyesters as well as "composite" non-woven meshes by concomitantly electrospinning different fibres in terms of both fibre morphology and polymer material. The 3D-architecture of the electrospun scaffolds fabricated in this research was controlled in terms of mutual fibre orientation by properly modifying the instrumental apparatus. This aspect is particularly interesting since the micro/nano-architecture of the scaffold is known to affect cell behaviour.Since last generation scaffolds are expected to induce specific cell response, the present research activity also explored the possibility to produce electrospun scaffolds bioactive towards cells. Bio-functionalized substrates were obtained by loading polymer fibres with growth factors (i.e. biomolecules that elicit specific cell behaviour) and it was demonstrated that, despite the high voltages applied during electrospinning, the growth factor retains its biological activity once

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Section: Poly(ε-caprolactone)supporting

confidence: 75%

Section: Biomaterialsmentioning

confidence: 99%

Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering

Gualandi

2011

Springer Theses

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“…This technique is not much useful for forming well-aligned nano fibres over large areas because the edge of such a bobbin has to be relatively sharp. 80 Yarns of aligned polyethylene oxide (PEO) fibres have been produced by introducing an electrostatic lens element to stabilize the liquid jet by Deitzel et al 81 Fong et al 82 Electro spun aligned yarns of nylon-6 by rapidly oscillating a grounded frame within the jet. Dersch et al 83 Used a metal frame as collector to produce well oriented parallel arrays of polyamide nano fibres with an average diameter of 50nm.…”

Section: Collector Distance and Geometrymentioning

confidence: 99%

Nano Fibres by Electro spinning: Properties and Applications

Nayak¹,

Padhye²

2017

JTEFT

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Electro spinning is a simple and versatile technique applicable to a wide range of polymers and solvents for the production of materials in nanometer scale. The nano fibrous materials produced by electro spinning process exhibit novel and significantly improved physical, chemical and biological properties. The small fibre diameter and the porous structure of the electrospun surfaces enable them for a wide range of applications such as wound dressing, tissue engineering scaffolds, vascular grafts, filters, membranes and sensors. In this article the principle, setup, materials used and the factors affecting the electro spinning process have been described. Also the properties & applications of electrospun fibres and the limitations & future scope of electro spinning process have been highlighted.

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“…Passive methods have also been attempted. These methods include using copper rings as lensing elements to dampen chaotic motion [261], and aperture plates that restrict and essentially "squeeze" down the electric field have also been employed to reduce resulting fiber mat spot size [262]. In addition to deposition location, alignment of polymer fibers and organic nanowires is desirable on many fronts and essential for equipment that utilizes and/or manipulates electromagnetic energy.…”

Section: Es Fabrication Of Organic Micro-and Nano-fiber Devicesmentioning

confidence: 99%

Electrospinning for nano- to mesoscale photonic structures

et al. 2016

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Abstract:The fabrication of photonic and electronic structures and devices has directed the manufacturing industry for the last 50 years. Currently, the majority of small-scale photonic devices are created by traditional microfabrication techniques that create features by processes such as lithography and electron or ion beam direct writing. Microfabrication techniques are often expensive and slow. In contrast, the use of electrospinning (ES) in the fabrication of microand nano-scale devices for the manipulation of photons and electrons provides a relatively simple and economic viable alternative. ES involves the delivery of a polymer solution to a capillary held at a high voltage relative to the fiber deposition surface. Electrostatic force developed between the collection plate and the polymer promotes fiber deposition onto the collection plate. Issues with ES fabrication exist primarily due to an instability region that exists between the capillary and collection plate and is characterized by chaotic motion of the depositing polymer fiber. Material limitations to ES also exist; not all polymers of interest are amenable to the ES process due to process dependencies on molecular weight and chain entanglement or incompatibility with other polymers and overall process compatibility. Passive and active electronic and photonic fibers fabricated through the ES have great potential for use in light generation and collection in optical and electronic structures/ devices. ES produces fiber devices that can be combined with inorganic, metallic, biological, or organic materials for novel device design. Synergistic material selection and postprocessing techniques are also utilized for broad-ranging applications of organic nanofibers that span from biological to electronic, photovoltaic, or photonic. As the ability to electrospin optically and/or electronically active materials in a controlled manner continues to improve, the complexity and diversity of devices fabricated from this process can be expected to grow rapidly and provide an alternative to traditional resource-intensive fabrication techniques.

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Controlled deposition of electrospun poly(ethylene oxide) fibers

Cited by 793 publications

References 10 publications

Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering

Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering

Nano Fibres by Electro spinning: Properties and Applications

Electrospinning for nano- to mesoscale photonic structures

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