Controlled Drug Release from Laser Treated Polymeric Carrier

Litauszki, Katalin; Igriczné, Éva Kiserdei; Pamlényi, Krisztián; Szarka, Györgyi; Kmetty, Ákos; Kovács, Zsolt

doi:10.1016/j.xphs.2022.08.018

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Restoring real dimensions from Equation (33), t av = (R 2 /D) τ av , leads to Equation (31). The fractional release profile for long cylindrical rods, Equation (32), and the complement fractional release from Equation (34) versus the dimensionless time of Equation (33) are depicted by green solid and dashed lines, respectively, in Figure 1. The vertical green dotted line corresponds to the value of the dimensionless average release time, Equation (35).…”

Section: Very Long Cylinders (H R)mentioning

confidence: 99%

“…The drug carriers used in relevant experiments usually have simple geometrical shapes, like thin films or slabs [30][31][32][33][34][35], spheres or pellets [36][37][38][39][40][41], and cylindrical tablets or fibers [42,43]. In the particular case of diffusion-controlled release from such geometries, exact analytical formulae concerning the fractional release profiles are well known, when the drug is homogeneously distributed initially and the formulation is uniform [44], or it has a core-shell structure [45].…”

Section: Introductionmentioning

confidence: 99%

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Exact Analytical Relations for the Average Release Time in Diffusional Drug Release

Kalosakas

2023

Processes

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Although analytical solutions for the problem of diffusion-controlled drug release from uniform formulations of simple geometries, like slabs, spheres, or cylinders, are well known, corresponding exact expressions for the average release times are not widely used. However, such exact analytical formulae are very simple and useful. When the drug is initially distributed homogeneously within the matrix, the average time of release from a sphere of radius R is tav=(1/15)R2/D and from a slab of thickness L is tav=(1/12)L2/D, where D is the corresponding drug diffusion coefficient. Regarding cylindrical tablets of height H and radius R, simple analytical expressions are obtained in the two opposite limits of either very long (H≫R) or very short (H≪R) cylinders. In the former case, of practically radial release, the average release time is tav=(1/8)R2/D, while in the latter case the same result as that of a slab with thickness H is recovered, tav=(1/12)H2/D, as expected. These simple and exact relations are useful not only for an estimate of the average release time from a drug carrier device when diffusion is the dominant mechanism of drug delivery, but also for the experimental determination of the drug diffusion coefficient in a release system of interest through the measured release profile, given the mean squared size of the formulation.

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Section: Very Long Cylinders (H R)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exact Analytical Relations for the Average Release Time in Diffusional Drug Release

Kalosakas

2023

Processes

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“…Nanocarriers can significantly promote the delivery of the drugs and improve their bioavailability, especially for drugs with poor water solubility. Some nanoparticles, such as polymers or mesoporous silica, have been developed as anticancer drug carriers [3][4][5][6]. However, the defects of their degradation resistance and low loading capacity limit their development.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Preparation of HCPT@IRMOF-3 Nanoparticles for pH-Responsive Anticancer Drug Delivery

Cheng

2023

Molecules

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Metal–organic frameworks (MOFs) are considered to be promising materials for drug delivery. In this work, a Zinc-based MOF nanocomposite IRMOF-3 was introduced as a drug carrier for 10-hydroxycamptothecine (HCPT). Without an extra drug-loading process, a nanoscale drug delivery material HCPT@IRMOF-3 was prepared via one-pot synthesis. The composition and structure of the material were investigated, and the drug release character was measured. Compared with preparing IRMOF-3 first and loading the drug, the one-pot-prepared HCPT@IRMOF-3 exhibited a higher drug-loading capacity. The material presented pH-responsive release. The HCPT release rate at pH 5.0 was significantly higher than that at pH 7.4. The cytotoxicity experiments showed that IRMOF-3 was non-toxic, and HCPT@IRMOF-3 exhibited notable cytotoxicity to Hela and SH-SY5Y cells. One-pot synthesis is a simple and rapid method for the preparation of an MOF drug delivery system, and IRMOF-3 can be potentially used in pH-responsive drug delivery systems.

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Fabrication of porous poly(L‐lactide‐co‐ε‐caprolactone) micropowder for microbubble effect and ultrasound‐mediated drug delivery

Lim

2024

Biopolymers

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Biodegradable elastic poly(L‐lactide‐co‐ε‐caprolactone) (PLCL) copolymer (50:50, lactide:caprolactone molar ratio) was synthesized and porous PLCL micropowders was fabricated by a simple method involving rapid cooling of 0.1, 0.5, and 1% (wt/vol) PLCL/dioxane spray into liquid nitrogen. The physicochemical properties of the porous PLCL micropowders were examined by measuring their pore size, pore morphology, and microbead size using a scanning electron microscopy (SEM) and dye and temozolomide (TMZ)‐release testing under ultrasound. Human U‐87MG, glioblastoma (GBM) cell culture tests were performed to evaluate cell cytotoxicity by released drug from PLCL micropowders. In this study, the porous PLCL micropowders prepared from 1 wt%/vol% PLCL solutions showed a highly porous structure, satisfactory mechanical properties, and optimal drug release efficiency compared with those produced from 0.1 or 0.5 wt%/vol% solutions. The results of the accumulated release test with the results of the absorbance of the dye initially applied, it was confirmed that more than 80% of the added dye was trapped inside the micropowder, and clearly GBM cytotoxicity effect could be observed by the released TMZ. The drug release system using micropowders and ultrasound can be applied as a drug supply system for various diseases such as brain tumors with low drug permeability.

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Controlled Drug Release from Laser Treated Polymeric Carrier

Cited by 4 publications

References 32 publications

Exact Analytical Relations for the Average Release Time in Diffusional Drug Release

Exact Analytical Relations for the Average Release Time in Diffusional Drug Release

One-Pot Preparation of HCPT@IRMOF-3 Nanoparticles for pH-Responsive Anticancer Drug Delivery

Fabrication of porous poly(L‐lactide‐co‐ε‐caprolactone) micropowder for microbubble effect and ultrasound‐mediated drug delivery

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