Controlled Drug Release Systems: Mechanisms and Kinetics

Sanopoulou, M.; Papadokostaki, Kyriaki G.

doi:10.1142/9789813223974_0001

Cited by 19 publications

(13 citation statements)

References 58 publications

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“…Poloxamer 188, also known as pluronic F-68, was obtained from Sigma-Aldrich in the form of pellets. It has an M n = 8400 g/mol with a composition of 80% PEO and 20% PPO and a density of 1.05 g/cm 3 . PVP of a Mw = 10,000 g/mol and a density 1.05 g/cm 3 was purchased from Sigma-Aldrich in the form of powder.…”

Section: Methodsmentioning

confidence: 99%

“…It has an M n = 8400 g/mol with a composition of 80% PEO and 20% PPO and a density of 1.05 g/cm 3 . PVP of a Mw = 10,000 g/mol and a density 1.05 g/cm 3 was purchased from Sigma-Aldrich in the form of powder. The glass transition temperatures (T g ) of poloxamer 188 and PVP was −65.6 and 96.3 °C, respectively, as determined by differential scanning calorimetry (DSC).…”

Section: Methodsmentioning

confidence: 99%

“…Due to the limitations regarding nontoxicity, chemical inertness, and biocompatibility, a research study for polymeric materials to meet the needs for new biomedical uses is commonly focused on modification of existing polymers with proven safety and biocompatibility . Examples of synthetic polymers used include both hydrophilic [poly(vinyl alcohol), poly(ethylene glycol), and poly(acrylic acid)] and hydrophobic ones [poly(lactic acid), poly(glycolic acid), and elastomeric polyisobutylene and polydimethylsiloxane]. , …”

Section: Introductionmentioning

confidence: 99%

“…1 Examples of synthetic polymers used include both hydrophilic [poly(vinyl alcohol), poly(ethylene glycol), and poly(acrylic acid)] and hydrophobic ones [poly(lactic acid), poly(glycolic acid), and elastomeric polyisobutylene and polydimethylsiloxane]. 2,3 Modification of hydrophobic elastomers through blending with hydrophilic polymers is widely applied to enhance the affinity of the former to water. The resulting increase in the permeability of water vapor 4,5 and of bioactive substances (drugs and proteins) is sought in controlled release systems, wound dressings, etc.…”

Section: Introductionmentioning

confidence: 99%

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Properties of Polydimethylsiloxane Modified by Blending with Polyvinylpyrrolidone and a Poly(ethylene oxide)-Poly(propylene oxide) Triblock Copolymer

Tsoka

Οικονόμου

Papadokostaki

et al. 2020

Ind. Eng. Chem. Res.

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Modification of biocompatible elastomers, especially polydimethylsiloxane (PDMS), through blending with hydrophilic excipients is sought in various biomedical applications to enhance the affinity of the hydrophobic polymer to water and increase the permeability of water vapor and of bioactive substances. In this work, a rubbery poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) block copolymer, known as poloxamer 188 (POL), and glassy polyvinylpyrrolidone (PVP) were incorporated in PDMS matrices at a 2.5–35% w/w content. POL, due to its amphiphilic nature, was better dispersed in smaller spherical domains than PVP in the matrix and exerted a stronger interfering effect on the curing reaction of PDMS, as indicated by DSC data. The Young modulus of PDMS-POL films decreased with increasing POL content and that of PDMS-PVP films remained practically unaffected up to a 20% w/w PVP content and exhibited an abrupt increase above 25% w/w. For a certain additive content, the water uptake was higher in the PDMS-POL films and produced a controllable and gradual increase in the permeability of caffeine over the whole range of additive content studied. Above a 25% w/w content, the PDMS-PVP films are characterized by a rather abrupt increase in caffeine permeability values, well above the maximum increase predicted by Maxwell’s model for strictly two-phase systems with fully discrete phase domains of the dispersed phase. The effects of PVP and POL on the examined properties of the modified PDMS matrices are discussed and interpreted in relation to the morphological features of the films with increasing additive content and the network characteristics of the PDMS phase.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Properties of Polydimethylsiloxane Modified by Blending with Polyvinylpyrrolidone and a Poly(ethylene oxide)-Poly(propylene oxide) Triblock Copolymer

Tsoka

Οικονόμου

Papadokostaki

et al. 2020

Ind. Eng. Chem. Res.

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show abstract

“…In such systems, the diffusion of the drug through the expandable polymer and the polymer swelling characteristic control the drug release rate. 29…”

Section: Diffusion and Dissolution Crssmentioning

confidence: 99%