Controlled Etching of Internal and External Structures of SiO<sub>2</sub> Nanoparticles Using Hydrogen Bond of Polyelectrolytes

Islam, Md. Shahinul; Choi, Won San; Lee, Ha-Jin

doi:10.1021/am501941c

Cited by 33 publications

(24 citation statements)

References 55 publications

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“…The lattice distance of 0.304 nm in d2 zone is consistent with (102) plane of hexagonal-phased CuS (JCPDS No. 63,64 The as-prepared Y 2 O 3 :Yb,Er@mSiO 2 -Cu x S (Fig. Thus, the HRTEM image confirms the successful formation of Cu x S onto the surface of Y 2 O 3 :Yb,Er hollow spheres.…”

Section: Phase Structure Morphology and Uc Luminescencementioning

confidence: 59%

Y₂O₃:Yb,Er@mSiO₂–Cu_xS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging

Yang

Wang

et al. 2015

Nanoscale

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Section: Phase Structure Morphology and Uc Luminescencementioning

confidence: 59%

Y₂O₃:Yb,Er@mSiO₂–Cu_xS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging

Yang

Wang

et al. 2015

Nanoscale

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“…After coating of CP, the peak A (401.9 eV) decreased, whereas peak B and peak C (400.2 eV, 398.4 eV) that were attributed to the CP clearly increased (Supplementary Fig. 5c) 44,45 . When APC was complexed with plasmid DNA, the elimination of peak A was due to the shielding effect after DNA complexation with APC (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Optogenetic Control of Programmable Genome Editing by Photoactivatable CRISPR/Cas9 Nanosystem in the Second Near-Infrared Window

Chen

Xin

et al. 2019

Preprint

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53We herein report the first optogenetically activatable CRISPR/Cas9 nanosystem for 54 programmable genome editing in the second near-infrared (NIR-II) optical window. The 55 nanosystem is composed of a cationic polymer-coated gold nanorod (APC) and Cas9 56 plasmid driven by a heat-inducible promoter. APC not only serves as a carrier for 57 intracellular plasmid delivery, but also can harvest external NIR-II photonic energy and 58 convert into local heat to induce the gene expression of Cas9 endonuclease. Due to high 59 transfection activity, APC shows strong ability to induce significant level of disruption in 60 different genome loci upon optogenetic activation. Moreover, the precise control of 61 genome editing activity can be simply programmed by finely tuning exposure time and 62 irradiation times in vitro and in vivo, and also enables editing at multiple time points, thus 63 proving the sensitivity and reversibility of such an editing modality. The NIR-II optical 64 feature of APC enables therapeutic genome editing at the deep tissue of the tumor-65 bearing mice, by which tumor growth could be effectively inhibited as a proof-of-concept 66 therapeutic example. Importantly, this modality of optogenetic genome editing can 67 significantly minimize the off-target effect of CRISPR/Cas9 in the most potential off-target 68 sites. The optogenetically activatable CRISPR/Cas9 nanosystem we have developed 69 offers a useful tool to expand the current applications of CRISPR/Cas9, and also defines 70 a programmable genome editing strategy towards unprecedented precision and 71 spatiotemporal specificity. 72 Introduction 73The RNA-guided clustered, regularly interspaced, short palindromic repeats (CRISPR)-74 associated nuclease protein 9 (Cas9) is originally an adaptive immune defense system, 75 by which many bacteria exploit to protect themselves from invading genetic elements 1 . It 76 has been recently harnessed as an efficient tool for genome editing in both single cells 77 and the whole organism for a wide range of biomedical applications in biology, genetics, 78 and medicine, etc 2,3 . In principle, the CRISPR/Cas9 is composed a single-guide RNA 79 (sgRNA) for the identification of DNA targets and a Cas9 endonuclease that can bind 80 and process the recognized DNA targets 4 . CRISPR/Cas9-based genome editing 81 technology offers a powerful and reliable strategy for the targeted modifications of the 82 genome, enabling the precise perturbation of virtually any genomic sequence in living 83 cells 2-6 . Due to its genome-wide specificity and multiplexing capability, Cas9 and its 84 variants have shown great potentials in the generation of loss-of-function animals 7,8 , the 85 correction of genetic disorders 9,10 , functional genome screening [11][12][13][14][15] , and the treatment of 86 infectious diseases 16,17 . Despite of these excitements, the lack of temporal and spatial 87 precision during editing process has severely constrained the current CRISPR/Cas9 88 systems from complicated and diverse genome-editing s...

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“…Furthermore, various selective etching methods have been reported, such as a cationic surfactant-assisted method. 209,235,253,259,265,283 As we mentioned above, MSNs with various structures and morphologies can be prepared by tuning the properties of silica. However, their dissolution behavior was not clearly investigated in most studies.…”

Section: Soft Template;mentioning

confidence: 99%

Colloidal Mesoporous Silica Nanoparticles

Yamamoto

Kuroda

2016

Bulletin of the Chemical Society of Japan

198

100

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IMMA. His current research interests include mesostructured materials, and several fields of inorganic materials chemistry. Some examples are intercalation chemistry, silicate chemistry, inorganic polymers, sol-gel chemistry, inorganic-organic hybrids, and self-organized materials. AbstractMesoporous silica nanoparticles (MSNs) with colloidal stability have attracted increasing interest because of their important properties, such as high transparency and cell uptake. Colloidal MSNs are comprehensively reviewed from the viewpoints of their preparation, characterization, and applications which include biomedical, catalytic, and optical materials. The following two points have been emphasized. The first point is that this review covers the widest range of introduction and discussion of the preparation and applications of both colloidal and noncolloidal MSNs. The second point is that this account contains a discussion from the viewpoints of both inorganic and colloid chemistries. After the introduction of the historical background of preparation of MSNs, preparative methods of colloidal MSNs and the major factors for the preparation of nanosized and colloidal MSNs are discussed. The methods to control the size, composition, morphology, and pore size of MSNs are also presented. Appropriate methods to obtain MSNs with high colloidal dispersibility are also discussed. Applications of colloidal MSNs are introduced with an emphasis on the colloidal stability. Issues to be addressed for further developments of colloidal MSNs are finally described.

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Controlled Etching of Internal and External Structures of SiO₂ Nanoparticles Using Hydrogen Bond of Polyelectrolytes

Cited by 33 publications

References 55 publications

Y₂O₃:Yb,Er@mSiO₂–Cu_xS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging

Y₂O₃:Yb,Er@mSiO₂–Cu_xS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging

Optogenetic Control of Programmable Genome Editing by Photoactivatable CRISPR/Cas9 Nanosystem in the Second Near-Infrared Window

Colloidal Mesoporous Silica Nanoparticles

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Controlled Etching of Internal and External Structures of SiO2 Nanoparticles Using Hydrogen Bond of Polyelectrolytes

Cited by 33 publications

References 55 publications

Y2O3:Yb,Er@mSiO2–CuxS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging

Y2O3:Yb,Er@mSiO2–CuxS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging

Optogenetic Control of Programmable Genome Editing by Photoactivatable CRISPR/Cas9 Nanosystem in the Second Near-Infrared Window

Colloidal Mesoporous Silica Nanoparticles

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Product

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About

Controlled Etching of Internal and External Structures of SiO₂ Nanoparticles Using Hydrogen Bond of Polyelectrolytes

Y₂O₃:Yb,Er@mSiO₂–Cu_xS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging

Y₂O₃:Yb,Er@mSiO₂–Cu_xS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging