Controlled Interconversion of a Dinuclear Au Species Supported by a Redox‐Active Bridging PNP Ligand Facilitates Ligand‐to‐Gold Electron Transfer

Vreeken, Vincent; Siegler, Maxime A.; Vlugt, Jarl Ivar van der

doi:10.1002/chem.201700360

Cited by 22 publications

(6 citation statements)

References 83 publications

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“…This ligand and its close relatives support a tremendous wealth of coordination chemistry, with tridentate pincer binding modes observed across the periodic table For coinage metals, however, PNP ligands often favor dinuclear coordination modes with bridging amides, such that each metal is only bound in a bidentate fashion . The first PNP gold complexes, recently reported by van der Vlugt and co‐workers, are structurally and electronically intriguing dinuclear gold systems that do not adopt pincer binding modes , …”

Section: Introductionmentioning

confidence: 91%

Synthesis and Characterization of Stable Gold(III) PNP Pincer Complexes

et al. 2018

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The first mononuclear Au III PNP pincer complexes [PNP = bis(2-diisopropylphosphinophenyl)amide] are reported. The chloro complex [(PNP)Au(Cl)][OAc F ] (OAc F = OCOCF 3 ) was synthesized by microwave irradiation of a tetrachloroaurate salt and the neutral PNHP ligand. Dehalogenation with AgOAc F afforded the trifluoroacetate-bound complex [(PNP)Au(OAc F )]-[OAc F ]. Both complexes were characterized by NMR spectroscopy and X-ray crystallography. Electronic absorption spectro-[a]

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Section: Introductionmentioning

confidence: 91%

Synthesis and Characterization of Stable Gold(III) PNP Pincer Complexes

et al. 2018

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“…The second reaction shown in Scheme , the reaction of the mixed gold(I)‐gold(III) complex 21 with silver triflimide, most likely involves radical intermediates as well, but actually does not produce a pincer complex. The unusual synthesis of the previously reported Cbz ( R PNP)H protioligand via oxidative coupling of two aryl rings represents a hitherto unique synthetic pathway to a complex such as the gold(I)‐gold(I) compound 22 , . For Pyr ( Ph PNP)H, similar dinuclear copper and silver complexes with protonated pyrrole rings have been prepared, either starting from the protioligand and different cuprous halides or from Pyr ( Ph PNP)‐coordinated nickel complexes via metal exchange with different silver salts …”

Section: Preparation Of Pnp Pincer Complexesmentioning

confidence: 99%

Phosphines and N‐Heterocycles Joining Forces: an Emerging Structural Motif in PNP‐Pincer Chemistry

2020

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Aminodiphosphines and their monoanionic amido derivatives are among the most widely used tridentate ligands. A good share of these ligands, in particular the ones that are based on a rigid N‐heterocyclic core, is predisposed to coordinate in a meridional fashion. Negatively charged derivatives of these meridionally coordinating N‐heterocyclic ligands satisfy all the criteria for PNP pincer scaffolds. Herein, these ligands and their coordination chemistry is reviewed from the perspective of coordination chemistry. For our discussion, ligands containing a protonated N‐heterocycle (e.g. pyrrole‐ or carbazole‐based PNP scaffolds) are to be distinguished from their counterparts that do not contain such an NH‐functionality (e.g. pyridine‐ or triazine‐based PNP scaffolds). Different synthetic methodologies for the preparation of PNP pincer complexes are presented and shown to often depend on the presence or absence of the aforementioned NH‐proton. The different reactivity patterns of the resulting complexes are sub‐divided into two categories, namely into metal‐centered reactions and reactions that result in a chemical transformation at the metal and the ligand. The latter represent ligand‐cooperative transformations, which often play a key role in catalysis, and are showcased by discussing selected applications in catalysis. It will become evident in this review that this relatively young research field is still emerging and far from reaching maturity. Finally, a brief overview on ligand/metal combinations that have not been explored to date is provided, to stimulate future research on PNP pincers featuring a central N‐heterocycle.

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“…Previous studies have reported that PNP ligands and carbanionic ligands alter the redox properties of gold. 59 , 60 In addition, ligands could facilitate the internalization of AuNPs at the cellular level, which may occur through the endocytosis process. 61 Although ligands help stabilize nanoparticles during their synthesis and facilitate their internalization, their presence in cells mainly affects the catalytic activity of their substrate.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress

Pinho¹,

Haupenthal²,

Fauser³

et al. 2022

JIR

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Proinflammatory cytokines and reactive oxygen species are released after muscle damage, and although they are necessary for the muscle regeneration process, an excess of these substances leads to the destruction of biomolecules and impairment of the repair system. Several drugs have emerged in recent years to control the muscle inflammatory response, and studies have shown that gold nanoparticles (AuNPs) have anti-inflammatory and antioxidant properties. This review reveals the effects of AuNPs on the inflammatory and redox mechanisms of muscles. We assessed the results of several studies published in different journals over the last 20 years, with a focus on the effects of AuNPs on possible aspects of muscle regeneration or recovery, namely, inflammatory processes and redox system mechanisms. A systematic database search was conducted using PubMed, Medline, Bireme, Web of Science, and Google Scholar to identify peer-reviewed studies from the 2000s. Combinations of keywords related to muscle damage, regeneration or repair, AuNPs, oxidative stress, and antioxidants were used in the search. This review did not address other variables, such as specific diseases or other biological effects; however, these variables should be considered for a complete understanding of the effects of AuNPs on skeletal muscles.

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Controlled Interconversion of a Dinuclear Au Species Supported by a Redox‐Active Bridging PNP Ligand Facilitates Ligand‐to‐Gold Electron Transfer

Cited by 22 publications

References 83 publications

Synthesis and Characterization of Stable Gold(III) PNP Pincer Complexes

Synthesis and Characterization of Stable Gold(III) PNP Pincer Complexes

Phosphines and N‐Heterocycles Joining Forces: an Emerging Structural Motif in PNP‐Pincer Chemistry

Gold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress

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