Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles

Gao, Yu; Chen, Yu; Ji, Xiufeng; He, Xinyu; Yin, Qi; Zhang, Zhiwen; Shi, Jianlin

doi:10.1021/nn2033105

Cited by 368 publications

(239 citation statements)

References 39 publications

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“…Very recently, several studies have demonstrated that SN particles not only can serve as promising drug carriers for high tumor targeting efficiency and therapy efficacy, but also for reducing the systematic toxicity [16,17]. However, the biological safety effect is sill being a pendent question of SN particles [18,19].…”

Section: Discussionmentioning

confidence: 99%

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Liu

Tang

et al. 2012

Chin. Sci. Bull.

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Hollow mesoporous nanomaterial is a kind of promising new drug delivery system due to their unique hollow structures. In order to evaluate the toxicity of silica nanorattle (SN) particles in vivo, 40 female mice were used in this study to investigate the acute toxicity and oxidative damage. Mice were intravenously injected with SN suspension in sterile 5% glucose at 40, 80 and 240 mg/kg, respectively. The control group was administrated with equal-volume 5% glucose. Weight, feed intake, hematology analysis, blood biochemical assay and histopathology diagnosis were examined. The activities of SOD, GSH and CAT were measured as well. The results demonstrated that the levels of ALT and AST in the mice treated with 240 mg/kg SN increased significantly as compared with the control group (P<0.05), whereas the contents of BUN and CREA changed unremarkably. The activity of SOD induced by SN in the liver decreased significantly (P<0.05). In summary, this study revealed that liver was the target organ of the SN. It also can be concluded that activity of SOD played an important role in liver injury caused by SN. silica nanorattle, acute toxicity, oxidative stress, superoxide dismutase Citation:Fu C H, Liu T L, Tang F Q, et al. Acute toxicity and oxidative damage induced by silica nanorattle in vivo.

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Section: Discussionmentioning

confidence: 99%

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Liu

Tang

et al. 2012

Chin. Sci. Bull.

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“…108 Gao et al used different sizes of MSNs to carry DOX, and then used them against drug-resistant breast cancer cells (MCF-7/Adr); the results suggested that the antitumor activity of MSNs showed a dependence on the pore size. 109 The larger pore size of MSNs can make the cancer cells to absorb DOX faster, so that the rapid accumulation of intracellular drugs plays a strong role in the reversal of MDR. It is clear that MSNs as a carrier for targeted therapy have great potential for overcoming MDR.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Zhang¹,

Tang²,

Liu³

et al. 2017

IJN

132

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Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity. Using nanoparticles as the carriers to realize passive targeting and active targeting can improve the efficacy of chemotherapy drugs significantly, reduce the mortality rate of cancer patients, and improve the quality of life of patients. In recent years, there has been extensive research on nanocarriers. In this review, the effects of several major parameters of nanoparticles on their physical and chemical properties are reviewed, and then the recent progress in the application of several commonly used nanoparticles is presented.

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“…Also, at pH 5.5 faster DOX release was observed for both particles compared to that at pH 7.4, which is in good accordance with the previous reports. 22 The slow rate of DOX release from F127-OMSN can provide more effective therapy by preserving desired drug concentration in the body for longer times.…”

mentioning

confidence: 99%

Pluronic polymer capped biocompatible mesoporous silica nanocarriers

et al. 2013

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A facile self-assembly method is described to prepare PEGylated silica nanocarriers using hydrophobic mesoporous silica nanoparticles and a pluronic F127 polymer. Pluronic capped nanocarriers revealed excellent dispersibility in biological media with cyto-and blood compatibilities.The high surface area and pore volume, good chemical stability and ease of surface functionalization of mesoporous silica nanoparticles (MSNs) make them promising materials for biological applications as drug carriers and theranostic agents.1,2 In addition silica based materials are generally accepted as biocompatible materials by the U.S. Food and Drug Administration (FDA). However, recent studies demonstrated their potential in vitro and in vivo toxicity, especially when their size is reduced to the nano scale. 3,4 Although the toxicity of silica based nanomaterials depends on several factors including particle size, shape, surface chemistry and porosity, [5][6][7] there is a general consensus that chemical structure of the surface is the predominant factor which determines the interactions with biological systems. 8 The surface of bare silica is covered with negatively charged silanol groups, which can electrostatically interact with positively charged tetraalkylammonium moieties of the cell membrane and can lead to cytotoxicity by membranolysis or inhibition of cellular respiration. 8,9 Also, rapid aggregation of silica based nanoparticles in biological media can result in mechanical obstruction in the capillary vessels of several vital organs, leading to organ failure and even death. 10,11 Therefore, replacing the surface silanol groups with biocompatible molecules is essential to improve the biocompatibility of MSNs. Among numerous polymeric or organosilane surface modification ligands, polyethylene glycol (PEG) is the mostly used one due to its well established biocompatibility, hydrophilicity, and antifouling properties.12 However, the PEGylation process has some limitations;(i) it mostly requires tedious organic synthesis and surface modification 13 and (ii) pores of MSNs may be closed by the long PEG polymer chains, which can hinder the drug loading process. To overcome these limitations, here we report a facile self-assembly method using octyl modified hydrophobic MSNs and an amphiphilic block copolymer (F127). F127, a FDA approved biocompatible pluronic polymer, contains two hydrophilic PEG blocks and a hydrophobic polypropylene oxide (PPO) between the two PEG blocks. 14 When the powder of hydrophobic MSNs is added into the F127 solution they are easily transferred into water by selfassembly of F127 molecules onto the MSN surface through the hydrophobic interaction between the PPO block of F127 and surface octyl groups of the MSNs (Scheme 1). In addition, cargo loaded and PEGylated MSNs can be simply prepared by loading the hydrophobic MSNs before the F127 capping process. The F127 capped particles are dispersible in both water and phosphate buffered saline (PBS), whereas uncapped MSNs are easily aggregated and precipitated...

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Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles

Cited by 368 publications

References 39 publications

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Pluronic polymer capped biocompatible mesoporous silica nanocarriers

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