Controlled loading and release of a model drug from polypeptide multilayer nanofilms

Ye, Zhong; Whittington, Catherine F.; Zhang, Ling; Haynie, Donald T.

doi:10.1016/j.nano.2007.03.002

Cited by 15 publications

(15 citation statements)

References 27 publications

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“…Key parameters for the communications with biological tissues are their magnetic properties, surface functionality, and solubility. Depending on the applications, the efficacy of magnetic colloids can thus be altered to vary their contrast capability [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Core-Shell Magnetic Polymer Colloids for Self assembled Multilayers Thin Films and Ultrasensitive Molecular Imaging

Fatima¹,

Ahmed²,

Ahmad³

et al. 2020

Preprint

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In the present work, novel core-shell polymer magnetic colloids are prepared and employed as a potential candidate in ultrasensitive molecular imaging. The synthesized colloids possess high colloidal stability, magnetization (43.85 emu g-1) and uniformity of particle size with an average diameter of 527 nm. FTIR spectrum of magnetic emulsion shows two characteristic peaks at 570 and 630 cm-1 which related to Fe-O vibration bands. Both T1 and T2 relaxation times were successfully measured. Based on signal intensities, the prepared colloids observed to perform as better T2 weighted contrast agents. The T2-weighted MR images showed significant signal intensity reduction and contrast darkening. Moreover, the prepared colloids were also employed to fabricate thin films via a facile method of layer by layer self-assembled multilayers (LBL-SAMU) to explore their potential application in imaging. Uniform particle size distribution with spherical morphologies was obtained for the fabricated bilayers.In addition, a 20% increment in iron contents was observed for 5-15 bilayer thin films decorated with film colloidal particles. The reported work opens new avenues for designing powerful T2 contrast agents in various biomedical applications such as analysis of biomacromolecules, diagnostics, and therapy.

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Section: Introductionmentioning

confidence: 99%

Core-Shell Magnetic Polymer Colloids for Self assembled Multilayers Thin Films and Ultrasensitive Molecular Imaging

Fatima¹,

Ahmed²,

Ahmad³

et al. 2020

Preprint

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“…More recently, LbL nanolayered film assemblies have been investigated as drug release systems (Chung & Rubner, 2002;Jiang & Li, 2009;Zhong, Whittington, Zhang, & Haynie, 2007) due to the possibility to control the drug release through manipulating the film/coating properties and to incorporate a wide range of functional biomolecules without substantial loss of their biological functions (Wang et al, 2007). The functional LbL multilayers can be obtained by chemical grafting of polyelectrolytes by functional moieties (Kaschak et al, 1999), alternate deposition of polyelectrolytes and functional molecules (Rousseau, Van der Auweraer, & De Schryver, 2000) or by post diffusion of the functional molecules into the multilayers (Jiang & Li, 2009;Zhong et al, 2007). A diversity of multilayered films has been developed to control bioactive compounds release by deploying different triggers such as pH, ionic strength, temperature and enzymes (Quinn & Caruso, 2004;Serizawa, Yamaguchi, & Akashi, 2002;Wood, Boedicker, Lynn, & Hammond, 2005).…”

Section: Introductionmentioning

confidence: 99%

Κ-carrageenan/chitosan nanolayered coating for controlled release of a model bioactive compound

Pinheiro

Bourbon

Quintas

et al. 2012

Innovative Food Science & Emerging Technologies

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Multilayer nanocoatings composed of κ-carrageenan, a sulphated anionic polysaccharide, and chitosan, a cationic polysaccharide, were produced by layer-by-layer deposition. The model cationic compound Methylene Blue (MB) was incorporated in different positions of the nanolayered coating and its loading and release behavior was evaluated. UV-VIS spectroscopy and quartz crystal microbalance analysis showed that the amount of MB loaded increased with the distance from the first layer, suggesting that the MB was able to diffuse into the κ-carrageenan/chitosan nanolayered coating and not only adhered to the surface of the layer immediately below it. For most of the tested conditions, the MB release from the κ-carrageenan/chitosan nanolayered coatings was successfully described by the linear superimposition model, which allowed concluding that MB transport is due to both concentration gradient and the polymer relaxation of the nanolayers. However, depending on temperature and pH of the medium and on the position of MB incorporated on the nanolayered coatings, different mechanisms prevail. Industrial relevance: The development of novel edible coatings with improved functionality and performance for e.g. fresh and minimally processed fruits is one of the challenges of the post-harvest industry. This work contributes to the understanding of the loading and release phenomena involved in structures at the nanoscale, which is useful for the development of bioactive compounds release systems for application in food industry. Moreover, the κ-carrageenan/chitosan nanolayered coatings represent a promising platform from which the controlled release of different bioactive compounds may be explored.

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“…LBL assembly as a facile and versatile method can incorporate a variety of templates like cross‐linked melamine resin latex particles, carbonates, polystyrene particles, enzyme microcrystals, and some other types of nanoparticles 17. The polymers involved in the process are also varied,18–20 that is, polycations including poly( l ‐glutamic acid) and (poly(allylamine hydrochloride) (PAH), as well as polyanions including poly( l ‐lysine), poly (styrene sulfonate) (PSS), and so forth 21, 22. Star‐shaped polymers show great potential for a wide range of applications, including drug delivery and advanced coatings.…”

Section: Introductionmentioning

confidence: 99%

Layer‐by‐layer supramolecular assemblies based on linear and star‐shaped poly(glycerol methacrylate)s for doxorubicin delivery

Sun¹,

Gao²,

Yang³

et al. 2012

J Biomedical Materials Res

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Hollow microcapsules, composed of pH responsive polyelectrolytes via a layer-by-layer (LBL) adsorption technique, were prepared. Linear or star-shaped poly(glycerol metha crylate)s (PGOHMAs) modified with 1,4-butanediamine and 1,2-ethanediamine (EDA) were synthesized and used as polycations. Poly(acrylic acid) was employed as polyanion and SiO2 (about 170 nm) as template. After LBL absorption, SiO2 cores were removed by HF treatment. The particle size and zeta potential were measured by dynamic light scattering, showing that the diameter of star-shaped amino-PGOHMA was larger than linear counterpart. The LBL assembly and core-etching process were evidenced by scanning electron microscope, transmission electron microscope, and energy dispersive spectrometer. The cytotoxicity experiments on human umbilical vein endothelial cells were carried out to evaluate the toxicity of LBL assembly. The star-shaped and EDA-modified PGOHMA exhibited better cell viability. The microcapsules were then used to load an anticancer drug, doxorubicin hydrochloride. High loading capacity (about 42%) and entrapment efficiency (84%) were obtained for star-shaped polymer-based microcapsules. The cumulative release rate was evaluated in vitro, showing faster release at an acidic condition compared to neutral pH. Confocal laser scanning microscopy evidenced the successful cellular uptake of DOX-loaded microparticles.

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Controlled loading and release of a model drug from polypeptide multilayer nanofilms

Cited by 15 publications

References 27 publications

Core-Shell Magnetic Polymer Colloids for Self assembled Multilayers Thin Films and Ultrasensitive Molecular Imaging

Core-Shell Magnetic Polymer Colloids for Self assembled Multilayers Thin Films and Ultrasensitive Molecular Imaging

Κ-carrageenan/chitosan nanolayered coating for controlled release of a model bioactive compound

Layer‐by‐layer supramolecular assemblies based on linear and star‐shaped poly(glycerol methacrylate)s for doxorubicin delivery

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