Controlled Magnetic Properties of Iron Oxide-Based Nanoparticles for Smart Therapy

Abstract

Magnetic nanoparticles provide a unique nanosystem for various smart therapy applications because of their biocompatibility, their nanostructures which can be prepared controllably to match with the interest of study and, specifically, their responses to an external magnetic field. Interests in utilizing magnetic nanoparticles for biomedical treatments originate from their external controllability of transportation and movement inside biological objects and magnetic heat generation which provide tremendous advantages for targeted drug delivery and controlled drug release as well as magnetic hyperthermia. Recent progress in synthesis and functionalization has led to the formation of various functional magnetic nanoparticles with controlled magnetic properties based on controlling their particle size, shape and composition. In this review, we focus on the synthesis, protection and functionalization of iron oxide-based magnetic nanoparticles in order to control magnetic properties of nanostructured systems. We also highlight the recent advances in the development of multifunctional therapeutic nanosystems combining magnetic nanoparticles and drugs as well as their superior efficacy in biomedical treatments with smart performance by including therapy and modulated drug delivery and release through magnetic heating.

Low toxic maghemite nanoparticles for theranostic applications

“…3 Superparamagnetic iron oxide nanoparticles (SPIONs) could be used in a combined manner, ie, not only as contrast agents for diagnostics and treatment monitoring but also as active substances for medical treatment. 4 In many cases, SPIONs represent a novel platform for simultaneous therapy and diagnostics (theranostics) in oncology.…”

Nanoparticle Filler Content and Shape in Polymer Nanocomposites

“…superparamagnetism) (Wiggers H., 2009). In other words, they are magnetic in the presence of a magnetic field but exhibit no remnant magnetization upon removing it (Nguyen D.T. and Kim K.-S., 2016).…”

“…and Kim K.-S., 2016). In contrast to dielectric and thermal/electric conductivity properties for which conventional bulk materials can be used, superparamagnetism is obtained only with nanoparticles (Nguyen D.T. and Kim K.-S., 2016) or nanocomposites made thereof (Sotiriou G.A.…”

On-Demand Release of Drug from Magnetic Nanoparticle-Loaded Alginate Beads

“…Utilization of magnetic field for biomedical applications including contrast agent, hyperthermia, and drug delivery has been bursting since the last decade due to the development of concepts and tools derived from nanotechnology [1][2][3]. New paradigms for theranostics have been created by developing multifunctional systems combining therapeutic and diagnostic agents within a single platform [4][5][6]. As a part of this, numerous research studies have been conducted with attempts to exploit significant advantages of delivery and controlled release of drug molecules, including the ability to target specific locations in the body and the reduction of the quantity of drug needed for better treatment efficiency with minimum severe side effects.…”