Controlled Noise: Evidence of Epigenetic Regulation of Single-Cell Expression Variability
Yan Zhong,
Siwei Cui,
Yongjian Yang
et al.
Abstract:Motivation: Understanding single-cell expression variability (scEV) or gene expression noise among cells of the same type and state is crucial for delineating population-level cellular function. While epigenetic mechanisms are widely implicated in gene expression regulation, a definitive link between chromatin accessibility and scEV remains elusive. Advances in single-cell techniques now enable simultaneous measurement of scATAC-seq and scRNA-seq within individual cells, presenting an unprecedented opportunity… Show more
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