Controlled ovarian hyperstimulation does not adversely affect endometrial receptivity in in vitro fertilization cycles

Levi, Andrew; Drews, M.R.; Bergh, Paul A.; Miller, Bradley T.; Scott, Richard T.

doi:10.1016/s0015-0282(01)01988-4

Cited by 86 publications

(54 citation statements)

References 31 publications

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“…[5,6] and consequently lower pregnancy rates. It is theorized that possible mechanisms that may alter embryo-endometrium synchrony may include a premature elevation of progesterone that could alter the normal endometrial window of implantation [3,5].…”

Section: Introductionmentioning

confidence: 99%

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Rodriguez-Purata

Lee

Whitehouse

et al. 2016

J Assist Reprod Genet

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Purpose The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium. Material and Methods This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with trophectoderm biopsy from January 2011 to July 2015 were included. Patients were divided into three groups: "Fresh Only," "Frozen Embryo Transfer ('FET) Only," and "Fresh ET then FET." For "Fresh Only" group (n = 345), PGS results were received within 24 h. For "FET Only" group (n = 514), results were expected after 24 h, and embryos were cryopreserved after biopsy; only FET was performed in this group (no fresh transfer). For "FET with a previous fresh ET" (n = 139) group, patients underwent a fresh ET with a subsequent FET, in which the same cohort of embryos was utilized. The main outcome measures were pregnancy rate (PR), clinical PR, implantation rate (IR), LBR, and early pregnancy loss rate. Results IRs were statistically higher in the "FET Only" group when compared to the "Fresh Only" group (59.5 vs. 50.6 %, p < 0.01) and the "FET with a previous fresh ET" (59.5 vs. 50.6 %, p < 0.05). LBR was statistically significant in the "FET Only" group when compared to the "Fresh Only" group (57.6 vs. 46.5 %, p < 0.005) but not when compared to "FET with a previous fresh ET" group (57.6 vs. 47.7 %, p = 0.07). Conclusions This analysis suggests euploid embryos to be more likely to implant and achieve a LBR in a synthetic FET cycle than in a fresh cycle.

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Section: Introductionmentioning

confidence: 99%

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Rodriguez-Purata

Lee

Whitehouse

et al. 2016

J Assist Reprod Genet

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“…Although potential negative effects of relatively high estradiol levels in the pre-ovulatory and early luteal phases have been documented [15][16][17][18], its effects during the peri-implantation and early pregnancy period are not well understood [16,19]. Additionally, these reported negative impacts have not been consistently seen [20][21][22][23]. The variability in several of these prior studies may be due to varying estradiol thresholds at which clinically significant differences in implantation and overall pregnancy outcomes were defined.…”

Section: Introductionmentioning

confidence: 99%

The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles

Imudia

Goldman

Awonuga

et al. 2013

J Assist Reprod Genet

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Purpose To determine the impact of elevated serum estradiol levels (EE 2 -defined as levels>90th percentile) on the day of hCG administration during IVF on oocyte fertilization, embryo development, implantation, clinical pregnancy and miscarriage rates. Methods A total of 2,995 consecutive IVF cycles in 1,889 patients with non-donor oocyte retrieval resulting in fresh embryo transfer between 1/1/2005 and 12/31/2011 were analyzed. Cycles were stratified by serum E 2 level on the day of hCG administration into those with levels >90th percentile and≤90th percentile. Rates of normal fertilization, embryo development, positive pregnancy test, implantation, clinical pregnancy and spontaneous miscarriage were compared. Results Serum estradiol above the 90th percentile on the day of hCG administration was associated with a significantly lower rate of normal fertilization (68.6±20 vs. 71.6±21, p = 0.02) when compared with patients with a lower serum estradiol threshold. The proportion of embryos that progressed from 2PN to 6-8 cell on day 3 was not different between the two groups. Although rates of positive pregnancy test (55.2 % vs. 57 %), implantation (26.4 % vs. 28.5 %) and clinical pregnancy (45.5 % vs. 49.4 %) were lower in patients with a higher estradiol threshold, these differences were not statistically significant. Similarly, there was no difference in the spontaneous miscarriage rates between the two groups (8.4 % vs. 7.1 %). Conclusions Serum estradiol levels above the 90th percentile on the day of hCG administration is associated with lower oocyte fertilization rate; however, such levels do not impact embryo development, implantation, clinical pregnancy or spontaneous miscarriage rates.

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“…Although it ensures obtaining a sufficient number of oocytes and thus embryos, ovarian hyper stimulation with exogenous gonadotropins is likely to be associated with modified endometrial development that may impact endometrial receptivity and success of implantation. These phenomenons would result from the inducing of an embryoendometrium asynchrony (histologic endometrial advancement), the up-regulation of Preceptor expression, and a negative correlation between implantation and premature progesterone elevation, impacting fresh implantation rates in normal and high responders (Shapiro et al, 2011a, b), despite some other controversial results (Levi et al, 2001). …”

Section: The Window Of Implantation and The Deciduamentioning

confidence: 99%

The actors of human implantation: gametes, embryo and endometrium

Gridelet¹,

Gaspard²,

Polese³

et al. 2012

Embryology - Updates and Highlights on Classic Topics

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Controlled ovarian hyperstimulation does not adversely affect endometrial receptivity in in vitro fertilization cycles

Cited by 86 publications

References 31 publications

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles

The actors of human implantation: gametes, embryo and endometrium

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