Controlled release application of multilamellar vesicles: a novel drug delivery approach

Agnihotri, Sunil A.; Soppimath, Kumaresh S.; Betageri, Guru V.

doi:10.3109/10717540903509027

Cited by 20 publications

(10 citation statements)

References 23 publications

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“…These results are compatible with other studies [60,93] that investigated that proniosomes are non-sticky provesicular powders that have higher flowability than the carriers. Improving the flowability of proniosomal powder compared to the pure carrier could be attributable to the coating of the surfactant film on the carrier surface and reducing the cohesive interactions between carrier particles [60].…”

Section: Determination Of the Micromeritic Propertiessupporting

confidence: 93%

Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

et al. 2020

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Curcumin is a natural compound that has many medical applications. However, its low solubility and poor stability could impede its clinical applications. The present study aimed to formulate dry proniosomes to overcome these pitfalls and improve the therapeutic efficacy of Curcumin. Curcumin-loaded proniosomes were fabricated by the slurry method according to 32 factorial design using Design-Expert software to demonstrate the impact of different independent variables on entrapment efficiency (EE%) and % drug released after 12 h (Q12h). The optimized formula (F5) was selected according to the desirability criteria. F5 exhibited good flowability and appeared, after reconstitution, as spherical nanovesicles with EE% of 89.94 ± 2.31% and Q12h of 70.89 ± 1.62%. F5 demonstrated higher stability and a significant enhancement of Q12h than the corresponding niosomes. The docking study investigated the ability of Curcumin to bind effectively with the active site of DNA polymerase of Herpes simplex virus (HSV). The antiviral activity and the safety of F5 were significantly higher than Curcumin. F5 improved the safety of Acyclovir (ACV) and reduced its effective dose that produced a 100% reduction of viral plaques. Proniosomes could be promising stable carriers of Curcumin to be used as a safe and efficient antiviral agent.

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Section: Determination Of the Micromeritic Propertiessupporting

confidence: 93%

Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

et al. 2020

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“…The phospholipid bilayer membrane was multilamellar or had several layers indicated by red arrows. This multilamellar wall serves to release antigens slowly or gradually (Agnihotri et al, 2010).…”

Section: Morphological Analysismentioning

confidence: 99%

Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant

et al. 2021

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“…[104] On the other hand, the interest in MLVs originates from the possibility of studying passive drug transport and sustained drug delivery application, due to a slower release rate in comparison to ULVs. [105] The ULVs can be, in turn, classified according to their different lateral sizes: 20-100 nmsmall unilamellar vesicles (SUVs); 100-1000 nm-large unilamellar vesicles (LUVs); and 1-200 µm-giant unilamellar liposomes/vesicles (GUVs). The MLVs are the result of direct redispersion of the lipid film in the aqueous medium from a film hydration approach.…”

Section: Wet-chemistry Preparationmentioning

confidence: 99%

Mastering the Tools: Natural versus Artificial Vesicles in Nanomedicine

Leggio

Arrabito

Ferrara

et al. 2020

Adv Healthcare Materials

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Naturally occurring extracellular vesicles and artificially made vesicles represent important tools in nanomedicine for the efficient delivery of biomolecules and drugs. Since its first appearance in the literature 50 years ago, the research on vesicles is progressing at a fast pace, with the main goal of developing carriers able to protect cargoes from degradation, as well as to deliver them in a time‐ and space‐controlled fashion. While natural occurring vesicles have the advantage of being fully compatible with their host, artificial vesicles can be easily synthetized and functionalized according to the target to reach. Research is striving to merge the advantages of natural and artificial vesicles, in order to provide a new generation of highly performing vesicles, which would improve the therapeutic index of transported molecules. This progress report summarizes current manufacturing techniques used to produce both natural and artificial vesicles, exploring the promises and pitfalls of the different production processes. Finally, pros and cons of natural versus artificial vesicles are discussed and compared, with special regard toward the current applications of both kinds of vesicles in the healthcare field.

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Controlled release application of multilamellar vesicles: a novel drug delivery approach

Cited by 20 publications

References 23 publications

Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant

Mastering the Tools: Natural versus Artificial Vesicles in Nanomedicine

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