Controlled-Release Drug Delivery Systems for Prolonged Gastric Residence: An Overview

Deshpande, Arati; Rhodes, C. T.; Shah, Navnit; Malick, A. Waseem

doi:10.3109/03639049609108355

Cited by 236 publications

(137 citation statements)

References 30 publications

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“…One attempt to overcome this problem is to extend the GI transit time of devices, by using floating dosage forms that have specific density lower than that of gastric fluids (1.004 g/cm 3 ) and remain buoyant in the stomach contents. The various buoyant preparations include hollow microspheres (microballoons), granules, powders, capsules, tablets (pills), and laminated films (Deshpande et al 1996(Deshpande et al , 1997Chien, 1997;Whiteheas et al 1998;Dressman 2000;Singh and Kim 2000).…”

mentioning

confidence: 99%

Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Junyaprasert

Pornsuwannapha

2008

Drug Delivery

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mentioning

confidence: 99%

Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Junyaprasert

Pornsuwannapha

2008

Drug Delivery

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“…4 It has been suggested that prolonged local availability of antibacterial agents may augment their effectiveness in treating Helicobacter Pylori related peptic ulcers. 5 The controlled gastric retention of solid dosage forms may be achieved by the mechanisms of mucoadhesion, flotation, sedimentation, expansion, modified shape systems, or by the simultaneous administration of pharmacological agents that delay gastric emptying. 6 When the drug is formulated with a gel forming polymer such as semisynthetic derivatives of cellulose, it swells in the gastric fluid with a bulk density less than one 7 .…”

Section: Introductionmentioning

confidence: 99%

FORMULATION & EVALUATION OF BILAYER FLOATING TABLETS OF METOPROLOL TARTRATE

Tagde¹,

Jain²,

Pathak³

2012

Int J of Biomed & Adv Res

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The objective of the present research was to develop a bi-layer tablet of Metoprolol tartrate using disintegrant starch for the fast release layer and HPMC K grade polymers for the sustaining layer. In vitro dissolution studies were carried out in an Indian Pharmacopoeia dissolution testing apparatus II (paddle method). The formulations gave an initial burst effect to provide the loading dose of the drug followed by sustained release for 12 h from the sustaining layer of matrix embedded tablets. The Invitro release study of this tablet indicated sustained release for Metoprolol tartrate and followed zero order release and 95% drug in 24h in vitro and it follow Fickian diffusion.

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“…Using current release technology, oral delivery for 24 h is possible for many drugs; however, the substance must be absorbed well throughout the whole gastrointestinal tract [1]. Most of the drug delivery systems are from ODDS [2].…”

Section: Research Articlementioning

confidence: 99%

Gastro-Floating Tablets of Repaglinide: Preparation and in Vivo Evaluation

Poornima

Abbulu

Mukkanti

2018

Asian J Pharm Clin Res

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Objective: Current research concerns the expansion of repaglinide matrix floating tablets, which are designed to prolong the gastric residence time, increase the drug bioavailability, and diminish the side effects.Methods: Different formulations of repaglinide floating tablets were prepared with different grades of hydroxypropyl methylcellulose (HPMC) and other agents. Evaluation parameters and in vivo bioavailability studies were conducted in the suitable model. Results:Among all the formulations, F21 containing HPMC K1500 PH PRM, Polyox WSR 303, and sodium bicarbonate, as gas generating agent was selected as optimized formulation based on physicochemical properties, floating lag time (36 s), and total floating time (>24 h). From in vitro dissolution studies, the optimized formulation F21 showed drug release of 98.92±5.19% within 24 h whereas 95.09±5.01% of the drug was released from the marketed product within 1 h. Conclusion:From in vitro and in vivo bioavailability studies repaglinide floating tablets expected to give a new choice for safe, economical, and increased bioavailability for effective management of diabetes mellitus.

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Controlled-Release Drug Delivery Systems for Prolonged Gastric Residence: An Overview

Cited by 236 publications

References 30 publications

Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir

FORMULATION & EVALUATION OF BILAYER FLOATING TABLETS OF METOPROLOL TARTRATE

Gastro-Floating Tablets of Repaglinide: Preparation and in Vivo Evaluation

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