Controlled release from directly compressible theophylline buccal tablets

Boyapally, Harikrishna; Nukala, Ravi Kumar; Bhujbal, Pranav; Douroumis, Dennis

doi:10.1016/j.colsurfb.2010.01.031

Cited by 57 publications

(28 citation statements)

References 35 publications

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“…Figures 2 and 3 show the effect of viscosity of simulated wound fluid on the mucoadhesive Please do not adjust margins Please do not adjust margins performance of the films. Both POL and CAR have strong hydrogen bonding groups while POL has sufficient chain flexibility and high molecular weight and viscosity which helps to improve the mucoadhesive performance of the prepared formulation 33 . When there is an intimate contact between the formulation and simulated wound fluid, hydrated polymer chains diffuse across the interface as a function of time.…”

Section: Mucoadhesion Studies By Texture Analysis [Simulated Wound Flmentioning

confidence: 99%

Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: a chemometrics factor analysis approach

Boateng

Pawar

2015

RSC Adv.

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The adhesive properties of two dressing types, solvent cast films and freeze-dried wafers have been determined and compared using two analytical techniques, combined with chemometrics data analysis. Films and wafers were prepared from gels containing polyox (POL) combined with carrageenan (CAR) or sodium alginate (SA), glycerol (GLY) as plasticiser (films) with streptomycin and diclofenac as model drugs. The gels were dried in an oven at 40°C or freeze-dried to obtain films and wafers respectively. The adhesive performance of the films and wafers was assessed with 6.67% w/v gel using a texture analyser to measure the stickiness, work of adhesion and cohesiveness. The effect of viscosity of simulated wound fluid[(containing (2% w/w or 5% w/w bovine serum albumin)] and mucin solution (2% w/w) present on the gelatin surface on texture analyser profiles was investigated. Furthermore, the adhesive properties were estimated and evaluated using attenuated total reflectance Fourier transform infrared spectroscopy by monitoring the diffusion of mucin solution [2% w/w in phosphate buffered saline (PBS) pH 7.4] through the formulations. The diffusion data was analysed using target factor analysis (chemometrics approach) to establish proof of concept for predicting adhesion by measuring mucin interaction and its diffusion through films and wafers. There was a significant effect of simulated wound fluid, viscosity, plasticizer (for films) and drug loading on the adhesive performance of both films and wafers. POL-SA films showed higher mucoadhesive performance in the presence of viscous simulated wound fluid containing 5% bovine serum albumin. Wafers and plasticised films demonstrated high detachment force indicating strong interactions between the chains of the polymers (POL, SA and CAR) and the model wound surface (gelatin). ATR-FTIR spectroscopy showed that mucin diffused independently through the solvent and across the films and wafers. POL-CAR films generally showed slower diffusion of mucin when compared with POL-SA films whilst the opposite effect was observed for diffusion through POL-CAR wafers and POL-SA wafers. Generally, diffusion through wafers was faster than the corresponding films.

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Section: Mucoadhesion Studies By Texture Analysis [Simulated Wound Flmentioning

confidence: 99%

Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: a chemometrics factor analysis approach

Boateng

Pawar

2015

RSC Adv.

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“…Variety of dosage forms like tablets (Boyapally et al, 2010, Kanjanabat & Pongjanyakul, 2011, discs (Yehia et al, 2008;Jaipal et al, 2013), patches (Abu-Huwaij et al, 2011;Kaur & Kaur, 2012;Govindasamy et al, 2013) and gels (Das et al, 2012;Bueno et al, 2013) have been reported in the literature for buccal delivery of drugs. Buccal discs are flat, thin solid unit non-flexible compacts; and are similar to buccal tablets.…”

Section: Introductionmentioning

confidence: 99%

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Jaipal

Pandey

et al. 2014

Drug Delivery

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“…Swellability index is the direct measurement of sorption of water into the mucoadhesive matrix. The ability of water intake by the polymers used in the formulations makes them swell and creates a passage for drugs to release either by erosion of the matrix or by movement of drug out of the intact matrix [37]. Swelling index continuously increased from 42% to more than 100% during time 1 h to 6 h reaching a plateau at 6 h. Swellable weight equal to the dry weight was achieved at 5 h. The maximum swelling was observed at 6 h as observed in Fig.…”

Section: Confirmation Formulationmentioning

confidence: 99%

Computer Aided Formulation and Characterization of Propranolol Hcl Buccal Tablet Using Polymeric Blend

Hanif¹,

Irfan²,

Danish³

et al. 2017

TOPROCJ

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Abstract:The current study was aimed to formulate a continuous release mucoadhesive buccal tablet containing propranolol HCl. The type and quantities of polymers as well as method of compression were set in a preliminary study (F1-F13). Direct compression method was employed in the main study (F14-F24) using Carbopol ® 934P (CP), ethylcellulose (EC), sodium alginate (SA), hydroxypropyl methylcellulose (HPMC k4M) and carboxymethylcellulose (CMC) as mucoadhesive polymers and were tested for physicochemical tests i.e. swellability, surface pH, mucoadhesive time, mucoadhesive strength, in vitro release etc. Results obtained from the study were optimized using NeuralPower ® 3.1, an artificial intelligence approach. Against the desirability of physicochemical parameters, the software optimized the ingredients as HPMC (150mg), CMC (25mg), CP (20mg) and EC (20mg). Outcome revealed that HPMC primarily contributed to the physicochemical properties of mucoadhesive formulation. To compare prediction, optimized ingredients were formulated (F25) and tested. The swellability index of confirmation formulation (F25) was 102% at 6 h. As predicted, similar release pattern was of F25 was obtained as 26% (0.5h), 34% (1h), 40% (2h), 45% (3h), 50% (4h), 62% (5h), 76% (6h), 85% (7h) and 97% (8h) respectively. For release kinetics, DD solver ® suggested the release of the drug to be non-Fickian.

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Controlled release from directly compressible theophylline buccal tablets

Cited by 57 publications

References 35 publications

Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: a chemometrics factor analysis approach

Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: a chemometrics factor analysis approach

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Computer Aided Formulation and Characterization of Propranolol Hcl Buccal Tablet Using Polymeric Blend

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