Controlled Release Microchips

Daniel, Karen; Duc, Hong Linh Ho; Cima, Michael J.; Langer, Robert

doi:10.1002/9780470498392.ch9

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Much of the controlled‐release technology developed over the last few decades that relies on polymer properties, for instance, may be adapted to a drug formulation and filled in implant reservoirs. For example, the product may combine polymer‐based drug delivery technology (‘passive release’) and microfabrication (MEMS‐based, ‘active release’) technology 4,8,88,89. There is great flexibility in tailoring these systems for specific applications because the release characteristics can be governed independently by release mechanism, reservoir geometry, and/or drug formulation.…”

Section: Implantable Mems‐based Drug Delivery Systems: Control Of Relmentioning

confidence: 99%

Microchips and controlled‐release drug reservoirs

Staples¹

2010

WIREs Nanomed Nanobiotechnol

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This review summarizes and updates the development of implantable microchip-containing devices that control dosing from drug reservoirs integrated with the devices. As the expense and risk of new drug development continues to increase, technologies that make the best use of existing therapeutics may add significant value. Trends of future medical care that may require advanced drug delivery systems include individualized therapy and the capability to automate drug delivery. Implantable drug delivery devices that promise to address these anticipated needs have been constructed in a variety of ways using micro- and nanoelectromechanical systems (MEMS or NEMS)-based technology. These devices expand treatment options for addressing unmet medical needs related to dosing. Within the last few years, advances in several technologies (MEMS or NEMS fabrication, materials science, polymer chemistry, and data management) have converged to enable the construction of miniaturized implantable devices for controlled delivery of therapeutic agents from one or more reservoirs. Suboptimal performance of conventional dosing methods in terms of safety, efficacy, pain, or convenience can be improved with advanced delivery devices. Microchip-based implantable drug delivery devices allow localized delivery by direct placement of the device at the treatment site, delivery on demand (emergency administration, pulsatile, or adjustable continuous dosing), programmable dosing cycles, automated delivery of multiple drugs, and dosing in response to physiological and diagnostic feedback. In addition, innovative drug-medical device combinations may protect labile active ingredients within hermetically sealed reservoirs.

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Section: Implantable Mems‐based Drug Delivery Systems: Control Of Relmentioning

confidence: 99%

Microchips and controlled‐release drug reservoirs

Staples¹

2010

WIREs Nanomed Nanobiotechnol

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“…The flow can be modulated by microvalves based on phase-modification of different materials such as paraffin [77,78,85], aqueous solutions [86], or hydrogels [87,88]. External forces can be applied on single-use valves so that flow is induced or impaired at a critical time point, such as by removing flow resistance [89][90][91] or by breaking apart a portion of a membrane [92][93][94].…”

Section: Integrated Micromachined Devicesmentioning

confidence: 99%

Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering

2012

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This paper reviews microfluidic technologies with emphasis on applications in the fields of pharmacy, biology, and tissue engineering. Design and fabrication of microfluidic systems are discussed with respect to specific biological concerns, such as biocompatibility and cell viability. Recent applications and developments on genetic analysis, cell culture, cell manipulation, biosensors, pathogen detection systems, diagnostic devices, high-throughput screening and biomaterial synthesis for tissue engineering are presented. The pros and cons of materials like polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), polystyrene (PS), polycarbonate (PC), cyclic olefin copolymer (COC), glass, and silicon are discussed in terms of biocompatibility and fabrication aspects. Microfluidic devices are widely used in life sciences. Here, commercialization and research trends of microfluidics as new, easy to use, and cost-effective measurement tools at the cell/tissue level are critically reviewed.

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“…More Surprisingly the gum exudates of T. catappa have not been studied so far as a controlled release polymer in the pharmaceutical field even though many other plant gum exudates like gum acacia, gum karaya, and gum ghatti have been successfully established for the purpose (17)(18)(19). Hence the objective of this study was to investigate the application of the gum exudates of T. catappa as a natural release-retarding polymer in the oral controlled drug delivery system using dextromethorphan hydrobromide (DH) as a model drug.…”

Section: Introductionmentioning

confidence: 99%

Rheological Characterization and Drug Release Studies of Gum Exudates of Terminalia catappa Linn

Kumar

Sasmal

Pal³

2008

AAPS PharmSciTech

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Abstract. The present study was undertaken to evaluate the gum exudates of Terminalia catappa Linn. (TC gum) as a release retarding excipient in oral controlled drug delivery system. The rheological properties of TC gum were studied and different formulation techniques were used to evaluate the comparative drug release characteristics. The viscosity was found to be dependent on concentration and pH. Temperature up to 60°C did not show significant effect on viscosity. The rheological kinetics evaluated by power law, revealed the shear thinning behavior of the TC gum dispersion in water. Matrix tablets of TC gum were prepared with the model drug dextromethorphan hydrobromide (DH) by direct compression, wet granulation and solid dispersion techniques. The dissolution profiles of the matrix tablets were compared with the pure drug containing capsules using the USP Basket apparatus with 500 ml phosphate buffer of pH 6.8 as a dissolution medium. The drug release from the compressed tablets containing TC gum was comparatively sustained than pure drug containing capsules. Even though all the formulation techniques showed reduction of dissolution rate, aqueous wet granulation showed the maximum sustained release of more than 8 h. The release kinetics estimated by the power law revealed that the drug release mechanism involved in the dextromethorphan matrix is anomalous transport as indicated by the release exponent n values. Thus the study confirmed that the TC gum might be used in the controlled drug delivery system as a release-retarding polymer.

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Controlled Release Microchips

Cited by 5 publications

References 13 publications

Microchips and controlled‐release drug reservoirs

Microchips and controlled‐release drug reservoirs

Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering

Rheological Characterization and Drug Release Studies of Gum Exudates of Terminalia catappa Linn

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