Controlled-Release Misoprostol Vaginal Insert in Parous Women for Labor Induction

Abstract

I.

A Comparison of Vaginal vs. Oral Misoprostol for Induction of Labor–Double Blind Randomized Trial

“…These complications are dose related higher the dose; more is uterine stimulation but shorter is the induction delivery interval [6]. With 50 lg vaginal misoprostol incidence of uterine contractile abnormalities have been reported to be 4.9% [5], 9% [9], 12% [1] and 26.92% in our study Ewert etal [10] observed these complications incidence as 3, 6.25, 10% with 25,100 and 200 lg controlled release vaginal inserts of misoprostol. While with 50 and 100 lg oral misoprostol uterine hyperstimulation incidence of 0.8% [5], 6.4% [11], respectively are reported.…”

Do we need a 200 μg misoprostol vaginal insert? A retrospective cohort study comparing the misoprostol vaginal insert to oral misoprostol

“…Since permanent fetal and maternal monitoring is not possible in daily hospital routine and missing experience in monitoring during the application, a general recommendation by the manufacturer is necessary. Offering a vaginal insert with a reduced dosage, for example, a 150 μg Misoprostol releasing less than 7 μg per hour could be an adequate alternative to decrease uterine hyperstimulation and avoid potential cesarean section due to fetal heart rate changes . Since we already know that a 150 μg MVI is only a little less effective than a 200 μg MVI it is not only speed and reduction in resource utilization that matters regarding the women's experience of induction of labor .…”

Misoprostol Vaginal Insert for Successful Labor Induction

“…3 Several previous studies have demonstrated the dose-response, efficacy, and safety of multiple doses of the misoprostol vaginal insert in nonpregnant women 4 and in pregnant women at term. [5][6][7] In this report, we describe the results of a phase II doseranging study of the MVI 100, MVI 150, and MVI 200 dose reservoirs in participants who required cervical ripening before the induction of labor.…”