Controlled Release of Agrochemicals Using pH and Redox Dual-Responsive Cellulose Nanogels

Hou, Xiaobang; Pan, Yuanfeng; Xiao, Huining; Liu, Jie

doi:10.1021/acs.jafc.9b00536

Cited by 66 publications

(33 citation statements)

References 34 publications

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“…Recently, both synthetic and natural polymers have been extensively utilized to develop polymeric nanogels, thereby expanding their technological applications. Although there are numerous reported polysaccharide nanogels, [42,44,79] i.e., chitosan, [80][81][82][83][84][85] cellulose, [17,86,87] alginate, [88][89][90][91] dextran, [92][93][94][95] SBNs are yet to reach their true potential. Figure 1 shows a general SBN formation route and their usage in diverse fields.…”

Section: Types Formation and Uses Of Sbnsmentioning

confidence: 99%

Starch Based Nanogels: From Synthesis to Miscellaneous Applications

Saracoglu

Ozmen

2021

Starch Stärke

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Nanogels are nanosized three-dimensional polymeric networks that are able to swell in a solvent. They are of great interest due to their high surface area, response to environmental stimuli, and high loading efficiency. In recent years, nanogels prepared from polysaccharides have captured broad attention because of their superior biocompatibility, easy gelation, and functionalization. In particular, starch based nanogels (SBNs) are promising nanomaterials for versatile applications including biomedical, food and pharmaceutical industries. Despite a high number of publications for other polysaccharide nanogels, a limited number of SBNs research articles are available in the literature. This review provides a brief summary of previous studies on the synthesis and applications of SBNs. Their current status is specified briefly covering the last decade. Some studies reveal that starch type, gelation time, and amylose/amylopectin ratio are critical parameters during SBNs synthesis. Numerous starch derivatives and combinations of starch with various polymers can facilitate their synthesis with desired features. Importantly, in vivo biodegradability and biocompatibility investigations are required to extend SBNs usage in the biomedical field including drug and peptide delivery. The overview provided by this review will offer a valuable understanding and insight to help direct the design and uses of SBNs.

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Section: Types Formation and Uses Of Sbnsmentioning

confidence: 99%

Starch Based Nanogels: From Synthesis to Miscellaneous Applications

Saracoglu

Ozmen

2021

Starch Stärke

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“…Controlled release of drug system has been extensively used to overcome the disadvantages of high drug concentration, high drug use and low drug utilization rate encountered in conventional drug formulations, enabling the steady release of drug at desirable concentrations (Ali and Ahmed 2018;Hou et al 2018;Hou et al 2019). The common drug carrier materials include film, microcapsules and hydrogel and so on.…”

Section: Introductionmentioning

confidence: 99%

“…To enable the controlled release of agrochemicals, Hou et al prepared a cellulose-based nanogel with pH and redox response using CYS etc. (Hou et al 2019). Tetracycline hydrochloride (TH) is a broad-spectrum antibiotic, which is often used in hydrogels as a simulation drug (Chen et al 2017;Liu et al 2018a).…”

Section: Introductionmentioning

confidence: 99%

Antibiotic release controlled by sugarcane bagasse-based hydrogels as responsive carriers

Yang

Cai

Pan

2021

Preprint

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This work focuses on the transesterification of sugarcane bagasse cellulose (SBC) using tert-butyl acetoacetate (t-BAA) to obtain bagasse cellulose acetoacetate (BCAA), and the preparation of redox/pH dual-responsive hydrogels with cystamine dihydrochlorate (CYS). BCAA and cellulose hydrogels were comprehensively characterized with scanning electron microscopy (SEM), Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), solubility and water retention. The results showed that BCAA was soluble in DMSO, and the degree of substitution (DS) ranged between 0.77 and 1.70, and the hydrogel had a certain water-retaining property. In addition, tetracycline hydrochloride (TH) was used as the model drug loaded in the hydrogel; and TH release can be manipulated or accelerated under reductive or weakly acidic conditions. According to the drug release kinetics analysis, suggested that the release mechanism of drug-loaded hydrogel was mainly driven by Fickian diffusion. The drug-loaded hydrogel also exhibited high antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Therefore, the dual-responsive and drug-loaded hydrogels have great potential in the applications associated with biomedicine.

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“…Stimuli-responsive CRFs provide advanced and smart controlled release of pesticides, where the CRFs present responses to small external stimuli, resulting in changes in their chemicalor physical properties favoring the “on-demand” release of loaded pesticides [ 18 ]. Until now, several kinds of stimuli responsive CRFs have been fabricated using abiotic or biotic stimuli, such as enzymes [ 13 ], redox [ 19 ], pH [ 20 ], temperature [ 21 ] and light [ 22 ]. Compared with other stimuli, light as an external trigger for pesticide release has received a lot of attention, since it is a clean and remote stimulus that can be spatially and temporally controlled by tuning the intensity, wavelength and site of irradiation [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Coumarin-Containing Light-Responsive Carboxymethyl Chitosan Micelles as Nanocarriers for Controlled Release of Pesticide

et al. 2020

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Currently, controlled release formulations (CRFs) of pesticides in response to biotic and/or abiotic stimuli have shown great potential for providing “on-demand” smart release of loaded active ingredients. In this study, amphiphilic biopolymers were prepared by introducing hydrophobic (7-diethylaminocoumarin-4-yl)methyl succinate (DEACMS) onto the main chain of hydrophilic carboxymethylchitosan (CMCS) via the formation of amide bonds which were able to self-assemble into spherical micelles in aqueous media and were utilized as light-responsive nanocarriers for the controlled release of pesticides. FTIR and NMR characterizations confirmed the successful synthesis of the CMCS-DEACMS conjugate. The critical micelle concentration (CMC) decreased with the increase in the substitution of DEACMS on CMCS, which ranged from 0.013 to 0.042 mg/mL. Upon irradiation under simulated sunlight, the hydrodynamic diameter, morphology, photophysical properties and photolysis were researched by means of dynamic light scattering (DLS), transmission electron microscopy (TEM), UV-vis absorption spectroscopy and fluorescence spectroscopy. Moreover, 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model pesticide and encapsulated into the CMCS-DEACMS micelles. In these micelle formulations, the release of 2,4-D was promoted upon simulated sunlight irradiation, during which the coumarin moieties were cleaved from the CMCS backbone, resulting in a shift of the hydrophilic–hydrophobic balance and destabilization of the micelles. Additionally, bioassay studies suggested that this 2,4-D contained which micelles showed good bioactivity on the target plant without harming the nontarget plant. Thereby, the light-responsive CMCS-DEACMS micelles bearing photocleavable coumarin moieties provide a smart delivery platform for agrochemicals.

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Controlled Release of Agrochemicals Using pH and Redox Dual-Responsive Cellulose Nanogels

Cited by 66 publications

References 34 publications

Starch Based Nanogels: From Synthesis to Miscellaneous Applications

Starch Based Nanogels: From Synthesis to Miscellaneous Applications

Antibiotic release controlled by sugarcane bagasse-based hydrogels as responsive carriers

Coumarin-Containing Light-Responsive Carboxymethyl Chitosan Micelles as Nanocarriers for Controlled Release of Pesticide

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