Controlled release of an osteogenic peptide from injectable biodegradable polymeric composites

Hedberg, Elizabeth L.; Tang, A.; Crowther, Roger S.; Carney, Darrell H.; Mikos, Antonios G.

doi:10.1016/s0168-3659(02)00261-4

Cited by 104 publications

(69 citation statements)

References 37 publications

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“…6) obtained from this experiment is consistent with the in vitro release profiles of many studies of bone engineering (Hedberg et al, 2002;Jansen et al, 2005;Luginbuehl et al, 2005;Ruhe et al, 2004), but some differences should be emphasized after introducing HAp. Generally, there is a higher percentage of BMP-2 released when more HAp nanoparticles were added.…”

Section: In Vitro Release Resultssupporting

confidence: 87%

Three‐dimensional fibrous PLGA/HAp composite scaffold for BMP‐2 delivery

Nie

Soh

et al. 2007

Biotech & Bioengineering

195

128

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A protein loaded three-dimensional scaffold can be used for protein delivery and bone tissue regeneration. The main objective of this project was to develop recombinant human bone morphogenetic protein-2 (rhBMP-2) loaded poly(D,L-lactide-co-glycolide)/hydroxylapatite (PLGA/HAp) composite fibrous scaffolds through a promising fabrication technique, electrospinning. In vitro release of BMP-2 from these scaffolds, and the attachment ability and viability of marrow derived messenchymal stem cells (MSCs) in the presence of the scaffolds were investigated. The PLGA/HAp composite scaffolds developed in this study exhibit good morphology and it was observed that HAp nanoparticles were homogeneously dispersed inside PLGA matrix within the scaffold. The composite scaffolds allowed sustained (2-8 weeks) release of BMP-2 whose release rate was accelerated with increasing HAp content. It was also shown that BMP-2 protein successfully maintained its integrity and natural conformations after undergoing the process of electrospinning. Cell culture experiments showed that the encapsulation of HAp could enhance cell attachment to scaffolds and lower cytotoxicity.

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Section: In Vitro Release Resultssupporting

confidence: 87%

Three‐dimensional fibrous PLGA/HAp composite scaffold for BMP‐2 delivery

Nie

Soh

et al. 2007

Biotech & Bioengineering

195

128

View full text Add to dashboard Cite

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“…Table 1 summarizes the most frequently used materials for the synthesis of materials in particulate form, and also includes the methods for production of these systems and intended applications, with a brief description of the most widely used groups following the table. (Herrmann and Bodmeier, 1998;Cruaud et al, 1999;Abazinge et al, 2000;Lam et al, 2000;Perez et al, 2002;De Rosa et al, 2003;Perugini et al, 2003;Jollivet et al, 2004;Wang et al, 2004;Norton et al, 2005) Release (Isobe et al, 1996;Yamazaki et al, 1996;Isobe et al, 1999;Walter et al, 1999;King and Patrick, 2000;Kim and Park, 2001;Ain et al, 2002;Hedberg et al, 2002;Murillo et al, 2002;Zhu et al, 2002;Diwan and Park, 2003;Jalón et al, 2003;…”

Section: Materials Used In the Synthesis Of Materials In Particulate mentioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

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For biomedical applications, materials small in size are growing in importance. In an era where 'nano' is the new trend, micro-and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro-and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarly, a multitude of methods are to produce particulate systems, and both materials and methods are critically reviewed here. Among the varied applications that materials in the particulate form can have, drug delivery systems are probably the most prominent, as these have been in the forefront of interest for biomedical applications. The basic concepts pertaining to drug delivery are summarized, and the role of polymers as drug delivery systems conclude this review. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E

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“…The water droplets may even be loaded with, for example, DNA [164]. Then, the emulsion of water-in-polymer solution is brought into an aqueous poly(vinyl alcohol) (PVA) solution to complete the NIPS by stirring for 3 h. By the use of a vortexer [168,169], a water-in-oil-in-water is achievable. Hot stirring of a paraffin/gelatin-water emulsion at 80°C is also reported.…”

Section: Scaffolds By Microsphere Sinteringmentioning

confidence: 99%

Design and preparation of polymeric scaffolds for tissue engineering

Weigel

Schinkel

Lendlein

2006

Expert Review of Medical Devices

210

154

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Polymeric scaffolds for tissue engineering can be prepared with a multitude of different techniques. Many diverse approaches have recently been under development. The adaptation of conventional preparation methods, such as electrospinning, induced phase separation of polymer solutions or porogen leaching, which were developed originally for other research areas, are described. In addition, the utilization of novel fabrication techniques, such as rapid prototyping or solid free-form procedures, with their many different methods to generate or to embody scaffold structures or the usage of selfassembly systems that mimic the properties of the extracellular matrix are also described. These methods are reviewed and evaluated with specific regard to their utility in the area of tissue engineering.Expert Rev. Med. Devices 3(6), 835-851 (2006) The technology of tissue engineering aims to generate new or substitute damaged or malfunctioning tissue or organs and could well become an alternative method to whole organ transplantation [1][2][3][4][5][6]. In the last decade particularly, enormous advances have been made in the area of tissue regeneration for therapeutical purposes. Tissue engineering is an interdisciplinary research area in which principles of material science/engineering and cell biology/life science are combined. The methods of tissue engineering have been applied to different types of tissue, including skin [7][8][9][10][11], bone [12][13][14][15][16], liver [17][18][19][20][21], intestine [22][23][24][25][26][27], esophagus [28][29][30][31][32], valve leaflets [33][34][35][36], muscle [37][38][39] and tongue [40][41][42], the vascular system [43][44][45][46][47], for craniofacial defects [48][49][50], tendons and ligaments [51][52][53][54][55], cartilage [56][57][58][59][60] and nerve tissue [61][62][63][64][65]. Since the early commercialization of tissue-engineered applications, for example, the work of Bell and colleagues [66], research with stem cells [3,[67][68][69] and the use of growth factors [70][71][72][73] that support cell differentiation and proliferation, have provided new opportunities in the field of tissue engineering. At present, tissue engineering methods generally require the use of a porous scaffold that serves as a matrix for initial cell attachment and subsequently for tissue formation in vitro and in vivo. Up to now scaffolds made from biomaterials have temporarily substituted the extracellular matrix (ECM). Such biomaterials can be of natural origin, such as organic collagen [74][75][76], fibrin glue [77][78][79], hyaluronic acid [80][81][82] or the inorganic-like coralline [83,84]. Synthetic polymeric materials have also been investigated, including, for example, aliphatic, copolyesters [85][86][87], polyhydroxyalkanoates [88][89][90] and polyethylene glycol [91,92], or inorganic materials, such as hydroxyapatite [48,93,94], tricalciumphosphate [95,96], glass ceramics and glass [97][98][99].The intrinsic material properties, such as the mechanical [100] or thermal [101,102] be...

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Controlled release of an osteogenic peptide from injectable biodegradable polymeric composites

Cited by 104 publications

References 37 publications

Three‐dimensional fibrous PLGA/HAp composite scaffold for BMP‐2 delivery

Three‐dimensional fibrous PLGA/HAp composite scaffold for BMP‐2 delivery

Materials in particulate form for tissue engineering. 1. Basic concepts

Design and preparation of polymeric scaffolds for tissue engineering

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