Controlled release of curcumin from electrospun fiber mats with antibacterial activity

Mahmud, Musavvir; Zaman, Sabrina; Perveen, Asma; Jahan, Rumana A.; Islam, Fakhrul; Arafat, M. Tarik

doi:10.1016/j.jddst.2019.101386

Cited by 84 publications

(47 citation statements)

References 46 publications

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“…diffusion and the swelling of PVA fibers, which happened immediately upon contact with the buffer solution. In contrast to this, the n values in phase II are markedly lower than 0.45, which is consistent with a Fick-type diffusion mechanism [83][84][85][86][87].…”

Section: Growth Inhibition Studies-minimal Inhibitory Concentrationsupporting

confidence: 70%

“…The release curves were fitted assuming an initial release phase from the beginning until about 60 min and a second release phase from 100 to 400 min. For the initial release of about 25-30%, which is rather a burst release [83,84], the rate is slightly higher for the monolithic PVA/TSC5 (0.6 versus 0.5). For the slower and sustained release phase, no plateau is reached after 390 h, and now, the release rate for the core-shell PVA/TSC10-PVA fibers is slightly higher (0.0020 versus 0.0016).…”

Section: Release Studiesmentioning

confidence: 91%

“…For phase II, R 2 values of 0.97 and 0.99 were obtained and exponents of 0.14 and 0.15 were obtained as well, respectively. Values for phase I lying between 0.45 and 0.89 indicate that the release of TSC from the PVA mats represents anomalous transport diffusion [83][84][85][86][87], which is probably governed by a combination of TSC diffusion and the swelling of PVA fibers, which happened immediately upon contact with the buffer solution. In contrast to this, the n values in phase II are markedly lower than 0.45, which is consistent with a Fick-type diffusion mechanism [83][84][85][86][87].…”

Section: Release Studiesmentioning

confidence: 99%

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Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

et al. 2020

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Mats of polyvinyl alcohol (PVA) core–shell nanofibers were produced using coaxial electrospinning in the presence of a thiosemicarbazone (TSC) N4-(S)-1-phenylethyl)-2-(pyridin-2-yl-ethylidene)hydrazine-1-carbothioamide (HapyTSCmB). Monolithic fibers with 0% or 5% TSC and core–shell fibers with 10% TSC in the spinning solution were studied to compare stability and release rates. SEM showed the formation of uniform, bead-free, cylindrical, and smooth fibers. NMR spectroscopy and thermal analysis (TG/DTA) gave proof for the chemical integrity of the TSC in the fiber mats after the electrospinning process. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy showed no TSC on the surface of the PVA/TSC-PVA fibers confirming the core–shell character. The TSC release profiles of the fibers as studied using UV-vis absorption spectroscopy showed a slower release from the PVA/TSC-PVA core–shell structure compared with the monolithic PVA/TSC fibers as well as lower cumulative release percentage (17%). Out of several release models, the Korsmeyer–Peppas model gave the best fit to the experimental data. The main release phase can be described with a Fick-type diffusion mechanism. Antibacterial properties were tested against the Gram-positive Staphylococcus aureus bacterium and gave a minimal inhibitory concentration of 12.5 μg/mL. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT)-based cytotoxicity experiments showed that the cell viability of fibroblast at different contents of TSC was slightly decreased from 1.5% up to 3.5% when compared to control cells.

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Section: Growth Inhibition Studies-minimal Inhibitory Concentrationsupporting

confidence: 70%

Section: Release Studiesmentioning

confidence: 91%

Section: Release Studiesmentioning

confidence: 99%

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Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

et al. 2020

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“…The antioxidant evaluation using DPPH assay demonstrated the antioxidant efficacy that ranged between 42.50% and 52.96% for electrospun polymeric fiber mats loaded with curcumin suggesting their good antioxidant effect for wound dressing applications [ 141 ]. Mahmud and co-workers designed electrospun fiber mats loaded with curcumin for antibacterial wound dressings [ 142 ]. The in vitro drug release profile of curcumin was temperature-dependent and controlled from the nanofibrous mats.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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“…For decades, a wide range of natural agents have been used effectively to treat various illnesses as they are safe and possess strong antioxidant and anti-inflammatory effects [18]. Curcumin (CUR), an antioxidative and anti-inflammatory natural polyphenol compound, is one of the major compounds of Curcuma longa.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Prevents Cyclophosphamide-Induced Lung Injury in Rats by Suppressing Oxidative Stress and Apoptosis

et al. 2020

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Curcumin (CUR) has been used since ancient times to treat several ailments as it possesses many pharmacological activities. This study intended to explore the mechanism underlying the protective effects of CUR in remodeling oxidative stress and apoptotic signals in cyclophosphamide (CP)-induced pulmonary injury in albino rats. CUR was administered at a dose of 300 mg/kg/day for 7 days and on the seventh day a single dose of CP (200 mg/kg) was given. Histopathological and ultrastructural examinations of CP-intoxicated rats showed complete alveolar obstruction, thickened inter-alveolar septa, enlarged blood vessels, severe inflammatory edema with pyknotic nuclei, and disappearance of cytoplasmic organelles. Significant increases in caspase-3, malondialdehyde (MDA), and protein carbonyl (PCO) and significant decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) were observed. In contrast, rats that received CUR showed clear and empty lumina with single row of pneumocytes, disappearance of edema, and no interstitial electron dense bodies in rats’ lung tissues. Additionally, CUR significantly reduced caspase-3, MDA, and PCO and increased SOD and GPx. In conclusion, these findings revealed the protective effects of CUR against CP-induced pulmonary injury in rats through suppressing oxidative damage and apoptosis.

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Controlled release of curcumin from electrospun fiber mats with antibacterial activity

Cited by 84 publications

References 46 publications

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Curcumin Prevents Cyclophosphamide-Induced Lung Injury in Rats by Suppressing Oxidative Stress and Apoptosis

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