Controlled Release of Doxofylline from Biopolymer Based Hydrogels

Gils, Palapparambil Sunny; Ray, Debajyoti; Sahoo, Prafulla Kumar

doi:10.5099/aj100400373

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Synthetic and natural polymers are used for drug delivery [29,30,31] and tissue engineering applications [32]. One of the synthetic polymers is PCL which posses many advantages.…”

Section: Introductionmentioning

confidence: 99%

Laser Surface Modification of Poly (e-caprolactone) Scaffold for Artificial Skin Applications

Hakeam¹,

Eid²,

Sharaf³

et al. 2013

Am. J. Biomed. Sci.

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Hard implants undergo detachment from the host tissues due to inadequate biocompatibility, poor adhesion and subsequent cell integration. Thereby, surface engineering seems to offer solutions for improved functionality and biocompatibility of material implants inside the biological environment. Polycaprolactone (PCL) thin film has been fabricated via uniaxial compression technique. Pulsed excimer laser was used to modify the PCL surface roughness. The laser pulses induced the formation of nanoripples on the membrane surface. The effect of laser parameters (pulse rate, energy and number of pulses) on the development of the nanoripples was studied. The surface morphology, roughness and the scaffold biocompatibility and cell viability were characterized using scanning electron microscopes (SEM), atomic force microscope (AFM) and MTT assay micro-plate reader. This work showed that applying laser pulses at different rates significantly modified the surface criteria. The modified scaffold was more biocompatible, rough, with enhanced cell attachment, proliferation and provided adequate host for cells to differentiate rather than the unmodified scaffold. The results clearly revealed that the modified scaffold with nanoripples on its surface could be a candidate implant material for artificial skin applications.

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“…Synthetic and natural polymers are used for drug delivery [29,30,31] and tissue engineering applications [32]. One of the synthetic polymers is PCL which posses many advantages.…”

Section: Introductionmentioning

confidence: 99%

Laser Surface Modification of Poly (e-caprolactone) Scaffold for Artificial Skin Applications

Hakeam¹,

Eid²,

Sharaf³

et al. 2013

Am. J. Biomed. Sci.

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“…In nutraceuticals, hydrolyzed collagen could be incorporated in various "dosage forms". Numerous hydrogels composed of synthetic acrylic derivatives like hydroxyethyl methacrylate, acrylic acid, methacrylic acid, Nisopropylacrylamide, and natural polysaccharides like chitosan exhibit pH-sensitive behavior and subsequently used for colonic drug delivery [5][6][7][8][9] . There are various copolymers of itaconic acid which also shows the pH-sensitive swelling and drug release behavior.…”

Section: Introductionmentioning

confidence: 99%

Hydrolyzed Collagen-Based Hydrogel System Design, Characterization and Application in Drug Delivery

Gils¹,

Sahu²,

Ray³

et al. 2012

Am. J. Biomed. Sci.

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This work was intended to develop a new hydrogel of collagen-g-Poly (acrylamide-co-itaconic acid) through chemical cross-linking by graft copolymerization of acrylamide (AM) and itaconic acid (IA) on to collagen (CGN) via redox initiator system of ammonium persulfate (APS) and N, N, N', N'-tetramethylethylenediamine (TMED), in presence of N, N'-methylene bis acrylamide (MBA) as crosslinking agent. Characterization of the hydrogel was done by FT-IR, TGA, SEM, LCMS/MS and HPLC. Valsartan (VAL) was successfully loaded into the prepared hydrogel. CGN-g-P(AM-co-IA) (H 10 ) formulation showed highest swelling capacity as well as VAL release in the biological media and release was controlled up to 24h. The release data of various formulations were fitted to Zero order, First order and Higuchi's kinetic models. It was observed that the release of drug from all the formulations followed Higuchi's kinetic model as its value of coefficient of determination is greater than that of others.

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Thermoresponsive cryogels of poly(2-hydroxyethyl methacrylate-co-N-isopropyl acrylamide) (P(HEMA-co-NIPAM)): fabrication, characterization and water sorption study

Katariya-Jain¹,

Bajpai²,

Bajpai³

et al. 2019

Polym. Bull.

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Controlled Release of Doxofylline from Biopolymer Based Hydrogels

Cited by 5 publications

References 8 publications

Laser Surface Modification of Poly (e-caprolactone) Scaffold for Artificial Skin Applications

Laser Surface Modification of Poly (e-caprolactone) Scaffold for Artificial Skin Applications

Hydrolyzed Collagen-Based Hydrogel System Design, Characterization and Application in Drug Delivery

Thermoresponsive cryogels of poly(2-hydroxyethyl methacrylate-co-N-isopropyl acrylamide) (P(HEMA-co-NIPAM)): fabrication, characterization and water sorption study

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