Controlled release of drug molecules in metal–organic framework material HKUST-1

Chen, Qing; Chen, Qiwei; Zhuang, Chong; Tang, Piaoping; Lin, Ning; Wei, Lian-Qiang

doi:10.1016/j.inoche.2017.03.027

Cited by 67 publications

(25 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a crystal, the DCM molecule occupies 75.5 Å 3 [27]. If packed, this number of DCM molecules will occupy 22.6 × 75.5 = 1706 Å 3 . This fits very well to the solvent-accessible volume = 2340 Å 3 (determined by SQUEEZE), with enough space for disorder.…”

Section: Crystal Structure Analysis Of the New Phases Of γ-Cd-mof-1mentioning

confidence: 99%

“…Over the last two decades, metal-organic frameworks (MOFs) have attracted increased attention due to their diverse properties and tunable structure [1,2]. Porous biocompatible MOFs inherit many useful features of the class of crystalline coordination polymers simultaneously providing a key advantage, such as low toxicity, which makes them ideal candidates for biomedical applications [3,4]. In particular, the host-guest chemistry of many MOFs allows using them for drug delivery [5].…”

Section: Introductionmentioning

confidence: 99%

“…To ensure the biocompatibility of MOFs, both components of the framework-metal and bridging polydentate ligand-should be nontoxic [6]. Several potential drug carrier candidates are already known [2,3,[7][8][9][10], with one of the promising classes of such MOFs that meet such criteria being based on a combination of cyclodextrin (CD) molecules and an alkali metal. CD is a nontoxic cyclic oligosaccharide consisting of six, seven, eight, or more D-glucopyranose units, traditionally designated as α-, β-, γ-, etc.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

et al. 2020

View full text Add to dashboard Cite

Cyclodextrin (CD) has been used to prepare biocompatible and nontoxic metal-organic frameworks (MOFs) suitable for biomedical applications as drug carriers. In this study, γ-CD/K-based MOF (γ-CD-MOF-1-α) was synthesized and its stability in various solvents was explored by single-crystal X-ray diffractometry (SCXRD) and powder X-ray diffractometry (PXRD). As a result of solvent-induced phase transformations, two novel crystalline phases of γ-CD-MOF-1 were discovered. The newly formed ε- and δ-phases crystallize in orthorhombic and tetragonal symmetry, respectively. In ε-phase, toluene was determined as a guest molecule by SCXRD. Interactions between γ-cyclodextrin and solvent molecules in ε-phase were evaluated using Hirshfeld surface analysis. The thermal stability of the new crystal forms of γ-CD-MOF-1 was analyzed by differential scanning calorimetry and thermogravimetric analysis.

show abstract

Section: Crystal Structure Analysis Of the New Phases Of γ-Cd-mof-1mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Metal–organic frameworks (MOFs) are well‐defined, highly porous crystalline materials formed by self‐assembly of inorganic metal ions and organic ligands. They have shown remarkable applications in various fields such as gas storage and separation, catalysis, chemical sensing, and drug delivery, because of their unique porous structure, high SA, and versatile preparation. However, only a few studies have used MOFs to control the release profile of volatile molecules.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation and controlled release of fragrances from functionalized porous metal–organic frameworks

et al. 2018

View full text Add to dashboard Cite

In the fragrance and perfume industry, the encapsulation and controlled release of fragrance is important to appeal to consumers and promote the quality of products. Here, we demonstrate that porous metal–organic frameworks (MOFs) can effectively encapsulate and release fragrant molecules in a controlled manner. The incorporation of functional groups into MOFs can improve the adsorption and release behavior of fragrant molecules. We find that polar ester‐type fragrances exhibit higher adsorption on polar hydroxyl‐functionalized MOF [UiO‐66‐(OH)2] than on nonpolar MOF (UiO‐66), while nonpolar terpenoid‐type fragrances show no adsorption difference between these two MOFs. The release profiles show that UiO‐66‐(OH)2 can prolong the release of polar fragrances compared with nonpolar fragrances. Both the experimental results and computer molecular modeling demonstrate that the hydroxyl groups in UiO‐66‐(OH)2 can form strong hydrogen binding with different ester fragrances. The releasing kinetics indicates that pore diffusion is the rate‐limiting step of fragrance release from MOFs. © 2018 American Institute of Chemical Engineers AIChE J, 65: 491–499, 2019

show abstract

“…JUCs (Jilin University China) JUC-199 [34] JUC-165 [35] JUC-166 [35] JUC-167 [35] 8 MOF-N (Metal-Organic Frameworks) MOF-5 [36] MOF-74 [36] MOF-177 [36] MOF-199 [36] [33] HKUST-1 [32] Co-HKUST [33] Frameworks) MOF-5 [36] MOF-74 [36] MOF-177 [36] MOF-199 [36] [35]…”

Section: Typical Preparationmentioning

confidence: 99%

Technology for the Remediation of Water Pollution: A Review on the Fabrication of Metal Organic Frameworks

2018

View full text Add to dashboard Cite

The ineffective control of the release of pollutants into water has led to serious water pollution. Compared with conditions in the past, the polluting components in aquatic environments have become increasingly complex. Some emerging substances have led to a new threat to the safety of water. Therefore, developing cost-effective technologies for the remediation of water pollution is urgently needed. Adsorption has been considered the most effective operational unit in water treatment processes and thus adsorption materials have gained wide attention. Among them, metal organic frameworks (denoted as MOFs) have been rapidly developed in recent years due to their unique physicochemical performance. They are characterized by larger porosity and larger specific surface area, easier pore structure designing, and comfortable structural modification. In many fields such as adsorption, separation, storage, and transportation, MOFs show a better performance than conventional adsorption materials such as active carbon. Their performance is often dependent on their structural distribution. To optimize the use of MOFs, their fabrication should be given more attention, without being limited to conventional preparation methods. Alternative preparation methods are given in this review, such as diffusion, solvent thermal, microwave, and ion thermal synthesis. Furthermore, developing functionalized MOFs is an available option to improve the removal efficiencies of a specific contaminant through pre-synthetic modification and post-synthesis modification. Post-synthesis modification has become a recent research hotspot. The coupling of MOFs with other techniques would be another option to ameliorate the remediation of water pollution. On one hand, their intrinsic drawbacks may be reduced. On the other hand, their performance may be enhanced due to their interaction behaviors. Overall, such coupling technologies are able to enhance the performance of an individual material. Because the excellent performance of MOF materials has been widely recognized and their developments have received wide attention, especially in environmental fields, in the present work we provide a review of fabrication of MOFs so as to motivate readers to deepen their understanding of the use of MOFs.

show abstract

Controlled release of drug molecules in metal–organic framework material HKUST-1

Cited by 67 publications

References 35 publications

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

Encapsulation and controlled release of fragrances from functionalized porous metal–organic frameworks

Technology for the Remediation of Water Pollution: A Review on the Fabrication of Metal Organic Frameworks

Contact Info

Product

Resources

About