Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management

Brigham, Natasha; Nofsinger, Rebecca; Luo, Xin; Dreger, Nathan Z.; Abel, Alexandra K.; Gustafson, Tiffany P.; Forster, Seth; Hermans, Andre; Ji, Ru-Rong; Becker, Matthew L.

doi:10.1016/j.jconrel.2020.11.052

Cited by 14 publications

(10 citation statements)

References 131 publications

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“…These materials have found extensive application in tissue engineering and various medical fields. Notably, their versatility makes them particularly suitable for repairing periodontal defects, as they exhibit excellent compatibility with soft and hard tissues [8][9][10][11]. PEU is a copolymer comprising three building blocks: an aliphatic diol or diamine, a diisocyanate, and a dicarboxylic acid or its anhydride.…”

Section: Of 18mentioning

confidence: 99%

“…), sodium carbonate (43.4 g, 0.41 mol, 3.1 eq), triphosgene (15.7 g, 0.05 mol, 0.4 eq.) (M n = 69.9 kDa, M w = 134.4 kDa, Ð M = 1.9, T g = 38.4 • C, T d = 235.2 • C) was produced via an interfacial step growth polymerization as described previously [9,25]. In summary, an interfacial polymerization process was carried out by combining chloroform and water.…”

Section: Peu (Poly Ester Urea) Synthesismentioning

confidence: 99%

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Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Toledo

Anselmi

Dal‐Fabbro

et al. 2023

JFB

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The objective of this research was to create and appraise biodegradable polymer-based nanofibers containing distinct concentrations of calcium trimetaphosphate (Ca-TMP) for periodontal tissue engineering. Poly(ester urea) (PEU) (5% w/v) solutions containing Ca-TMP (15%, 30%, 45% w/w) were electrospun into fibrous scaffolds. The fibers were evaluated using SEM, EDS, TGA, FTIR, XRD, and mechanical tests. Degradation rate, swelling ratio, and calcium release were also evaluated. Cell/Ca-TMP and cell/scaffold interaction were assessed using stem cells from human exfoliated deciduous teeth (SHEDs) for cell viability, adhesion, and alkaline phosphatase (ALP) activity. Analysis of variance (ANOVA) and post-hoc tests were used (α = 0.05). The PEU and PEU/Ca-TMP-based membranes presented fiber diameters at 469 nm and 414–672 nm, respectively. Chemical characterization attested to the Ca-TMP incorporation into the fibers. Adding Ca-TMP led to higher degradation stability and lower dimensional variation than the pure PEU fibers; however, similar mechanical characteristics were observed. Minimal calcium was released after 21 days of incubation in a lipase-enriched solution. Ca-TMP extracts enhanced cell viability and ALP activity, although no differences were found between the scaffold groups. Overall, Ca-TMP was effectively incorporated into the PEU fibers without compromising the morphological properties but did not promote significant cell function.

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Section: Of 18mentioning

confidence: 99%

Section: Peu (Poly Ester Urea) Synthesismentioning

confidence: 99%

Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Toledo

Anselmi

Dal‐Fabbro

et al. 2023

JFB

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“…To obtain a biodegradable NO carrier with a low inflammatory response for wound healing, a series of tryptophan-based poly(ester urea)s (Trp-PEUs) with good degradation and biocompatibility were developed for the fabrication of electrospun composite nanofiber mats. Trp-PEUs are novel polymers synthesized from tryptophan (Trp), diols, and hexamethylene diisocyanate (HDI), and the chemical structure of Trp-PEUs has great flexibility . Trp, an essential amino acid, regulates immune response and wound healing. , What’s more, Trp could inhibit the formation of biofilms by disrupting interactions and adherence between bacteria. − The polymers can be degraded, and the byproducts (amino acid metabolites, diacids, and carbon dioxide) are readily absorbed and excreted by the body, thus, they possess very limited inflammatory responses .…”

Section: Introductionmentioning

confidence: 99%

“…Trp-PEUs are novel polymers synthesized from tryptophan (Trp), diols, and hexamethylene diisocyanate (HDI), and the chemical structure of Trp-PEUs has great flexibility. 42 Trp, an essential amino acid, regulates immune response and wound healing. 43,44 What's more, Trp could inhibit the formation of biofilms by disrupting interactions and adherence between bacteria.…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide-Releasing Tryptophan-Based Poly(ester urea)s Electrospun Composite Nanofiber Mats with Antibacterial and Antibiofilm Activities for Infected Wound Healing

Qiu

Wang

et al. 2022

ACS Appl. Mater. Interfaces

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Bacterial biofilms on wounds can lead to ongoing inflammation and delayed reepithelialization, which brings a heavy burden to the medical systems. Nitric oxide based treatment has attracted attention because it is a promising strategy to eliminate biofilms and heal infected wounds. Herein, a series of tryptophan-based poly(ester urea)s with good biodegradation and biocompatibility were developed for the preparation of composite mats by electrospinning. Furthermore, the mats were grafted with a nitric oxide donor (nitrosoglutathione, GSNO) to provide one type of NO loading cargo. The mats were found to have a prolonged NO release profile for 408 h with a maximum release of 1.0 μmol/L, which had a significant effect on killing bacteria and destructing biofilms. The designed mats were demonstrated to promote the growth of cells, regulate inflammatory factors, and significantly improve collagen deposition in the wound, eventually accelerating wound-size reduction. Thus, the studies presented herein provide insights into the production of NO-releasing wound dressings and support the application of full-thickness wound healing.

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“…Currently, nanomedicine and preclinical investigations are gaining increasing attention in pharmaceutical and biomedical research 19 - 22 , among which the injectable, thermo-sensitive hydrogel has been widely used in drug delivery system 23 . A series of thermosensitive polymer hydrogels, such as poly (ethylene glycol)-block-poly (ε-caprolactone)-graft-poly (2-(guanidyl) ethyl methacrylate) (mPEG- b -PCL- g -PGEM, PECG), poly (DL-lactide- co -glycolide- b -ethylene glycol- b -DL-lactide- co -glycolide, PLGA-PEG-PLGA) and chitosan hydrogels 24 - 26 , have been applied as delivery systems for local anesthetics.…”

Section: Introductionmentioning

confidence: 99%

Injectable electrospun fiber-hydrogel composite sequentially releasing clonidine and ropivacaine for prolonged and walking regional analgesia

Chen¹,

Yao²,

Wang³

et al. 2022

Theranostics

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Rationale : Peripheral nerve block is a traditional perioperative analgesic method for its precise pain control and low systemic toxicity. However, a single low dose of local anesthetic merely provides a few hours of analgesia, and high dose results in irreversible toxicity, whereas continuous infusion of anesthetics is expensive and complicated. Therefore, it is necessary to develop a long-acting and sensory-selective local anesthetic for safe perioperative analgesia. Methods : An injectable composite comprising ropivacaine-loaded poly (ε-caprolactone) electrospun fiber and clonidine-loaded F127 hydrogel (Fiber-Rop/Gel-Clo composite) was developed for long-acting and walking regional analgesia with barely one dose. The peripheral nerve blockade effect of the composite was evaluated in a rat sciatic nerve block model. Also, the biodegradability and biosafety of the composite was evaluated. Results : The preferentially released Clo from the hydrogel rapidly constricted the peripheral arterial vessels, reducing the blood absorption of Rop and thus enhancing the local Rop accumulation at the injection site. The subsequently sustainable release of Rop from the fiber, significantly prolonged the sciatic nerve block of rats. Remarkably, an amazing sensorimotor segregation effect was achieved, as the sensory blockade (32.0 ± 1.4 h) lasted significantly longer than the motor blockade (20.3 ± 0.9 h). Additionally, the Fiber-Rop/Gel-Clo composite presented good biodegradability and biosafety in vivo . Conclusions : Our designed Fiber-Rop/Gel-Clo composite with minimal invasion, prolonged synergistic analgesia, and strikingly sensorimotor segregation effect, posted a promising prospect for regional long-term walking analgesia in clinical treatment.

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Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management

Cited by 14 publications

References 131 publications

Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Nitric Oxide-Releasing Tryptophan-Based Poly(ester urea)s Electrospun Composite Nanofiber Mats with Antibacterial and Antibiofilm Activities for Infected Wound Healing

Injectable electrospun fiber-hydrogel composite sequentially releasing clonidine and ropivacaine for prolonged and walking regional analgesia

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