Controlled release of oxytetracycline in sheep

Sun, Ye; Peng, Yingxu; Aksornkoae, Napasinee; Johnson, James R.; Boring, J Gregg; Scruggs, Daniel W.; Cooper, Robert C.; Laizure, S. Casey; Shukla, Atul

doi:10.1016/s0168-3659(02)00286-9

Cited by 15 publications

(5 citation statements)

References 6 publications

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“…The extraction and detection method of OTC in plasma were based on a previously described method (Sun et al, 2002;Miller et al, 2007) with slight modifications. Briefly, 200 lL of buffalo plasma was deproteinated by adding 50 lL of 15% trichloroacetic acid in acetonitrile (ACN) in a 1 mL conic Eppendorf tube and then vortexed for 1 min.…”

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confidence: 99%

Disposition of a long‐acting oxytetracycline formulation in Thai swamp buffaloes (Bubalus bubalis)

Poapolathep

Wongpanit

Tanhan

et al. 2016

Vet Pharm & Therapeutics

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The present study aimed to characterize the pharmacokinetic profile of oxytetracycline long-acting formulation (OTC-LA) in Thai swamp buffaloes, Bubalus bubalis, following single intramuscular administration at two dosages of 20 and 30 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 504 h. The plasma concentrations of OTC were measured by high-performance liquid chromatography (HPLC). The concentrations of OTC in the plasma were determined up to 264 h and 432 h after i.m. administration at doses of 20 and 30 mg/kg b.w., respectively. The C values of OTC were 12.11 ± 1.87 μg/mL and 12.27 ± 1.92 μg/mL at doses of 20 and 30 mg/kg, respectively. The AUC values increased in a dose-dependent fashion. The half-life values were 52.00 ± 14.26 h and 66.80 ± 10.91 h at doses of 20 and 30 mg/kg b.w, respectively. Based on the pharmacokinetic data and PK-PD index (T > MIC), i.m. administration of OTC at a dose of 30 mg/kg b.w once per week might be appropriate for the treatment of susceptible bacterial infection in Thai swamp buffaloes.

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confidence: 99%

Disposition of a long‐acting oxytetracycline formulation in Thai swamp buffaloes (Bubalus bubalis)

Poapolathep

Wongpanit

Tanhan

et al. 2016

Vet Pharm & Therapeutics

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“…The OTC extraction method was performed as previously described [13,14] and revalidated in spiked plasma of the crocodiles. Briefly, 500 µL of freshwater crocodile plasma was deproteinated by adding 50 µL of 15% trichloroacetic acid in acetonitrile (ACN) in a 1-mL conic Eppendorf tube and then vortexed for 1 min.…”

Section: Sample Extraction Proceduresmentioning

confidence: 99%

Pharmacokinetics of a Long-Acting Formulation of Oxytetracycline in Freshwater Crocodiles (Crocodylus siamensis) after Intramuscular Administration at Three Different Dosages

Poapolathep

Klangkaew

Phaochoosak

et al. 2020

Animals

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To date, the necessary pharmacokinetic information has been limited to establish suitable therapeutic plans for freshwater crocodiles. Therefore, this study was conducted to evaluate the pharmacokinetic profile of the oxytetracycline long-acting formulation (OTC-LA) in the freshwater crocodile, Crocodylus siamensis, following a single intramuscular (i.m.) administration at three different dosages of 5, 10 and 20 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 216 h after i.m. administration at the three different dosages. The plasma concentrations of OTC were measured using a validated liquid chromatography tandem-mass spectrometry (LC-MS/MS) method. The Cmax (± SD) values of OTC were 2.15 ± 0.51 µg/mL, 7.68 ± 1.08 µg/mL and 17.08 ± 2.09 µg/mL at doses of 5, 10 and 20 mg/kg b.w., respectively. The elimination half-life values were 33.59 ± 2.51 h, 38.42 ± 5.47 h and 38.04 ± 1.98 h at dosages of 5, 10 and 20 mg/kg b.w., respectively. Based on the pharmacokinetic data, the pharmacokinetic/pharmacodynamic (PK/PD) index, the susceptibility break-point and plasma protein binding, a dosage once every two weeks of 10 mg/kg b.w. OTC intramuscularly might be suitable for initiating the treatment of susceptible bacterial infections in freshwater crocodiles. However, further PK/PD studies are warranted to confirm whether the dose rates used in this study can produce longer-term antimicrobial success for diseases caused by susceptible bacteria in freshwater crocodiles.

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“…In 2017, the most frequent request FARAD received regarding oxytetracycline in both sheep and goats was for WDI recommendations following SC administration of long-acting formulations. Subcutaneous administration of oxytetracycline to sheep 38 and goats 37 has been evaluated in 2 studies. Currently, FARAD recommends a 35-day meat and at least a 6-day milk WDI for small ruminants following SC administration of a single dose of oxytetracycline (20 mg/kg).…”

Section: Combined Florfenicol-flunixin Meglumine Formulation-mentioning

confidence: 99%