Controlled release of testosterone by polymer-polymer interaction enriched organogel as a novel transdermal drug delivery system: Effect of limonene/PG and carbon-chain length on drug permeability

Charoensumran, Preeyarad; Ajiro, Hiroharu

doi:10.1016/j.reactfunctpolym.2019.104461

Cited by 23 publications

(10 citation statements)

References 39 publications

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“…After cooling down to an appropriate temperature, it forms a gel that appears white in color. It has been observed that the co-existence of limonene with GP1 and PG influences its rheological behavior to some extent, whereas their chemical characteristics are not significantly affected [7,15,19,23]. The GP1/PG organogels tend to have increased gel moduli due to the incorporation of limonene, which gives an indication of increased gel physical stability [24].…”

Section: Limonene Gp1/pg Organogelsmentioning

confidence: 99%

Organogel: A Propitious Carman in Drug Delivery System

Bedse¹,

Singh²,

Raut³

et al. 2023

Advanced Drug Delivery Systems

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A gel is a semi-solid formulation having an external solvent phase that is either apolar (organogels) or polar (hydrogels) that is immobilized inside the voids contained in a three-dimensional networked structure. Organogels are bi-continuous systems composed of apolar solvents and gelators. When used at a concentration of around 15%, the gelators form self-assembled fibrous structures that become entangled with one another, resulting in the formation of a three-dimensional networked structure. The resulting three-dimensional networked structure blocks the flow of the external apolar phase. Sterol, sorbitan monostearate, lecithin, and cholesteryl anthraquinone derivatives are examples of gelators. The unique characteristics such as thermo-reversibility, viscoelasticity, and versatility impart a longer shelf-life, prolonged drug release, and patient compliance. These characteristics can easily be adjusted by simple formulation modifications, resulting in highly-structured architectures. Organogels are more likely to be used in various types of delivery systems because of their ability to entrap both hydrophilic and hydrophobic molecules inside their structure. Their combination with other materials allows for tailoring their potential as dosage forms. Organogels have potential applicability in numerous ways; hence this article discusses the various aspects of it.

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Section: Limonene Gp1/pg Organogelsmentioning

confidence: 99%

Organogel: A Propitious Carman in Drug Delivery System

Bedse¹,

Singh²,

Raut³

et al. 2023

Advanced Drug Delivery Systems

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“…One of the advantages of the TDDSs is the avoidance of the first pass metabolism through the hepatic portal vein system and GIT, which represents a considerable impediment for oral administration [ 152 ]. Another benefit of TDDSs is represented by the ability to avoid loaded drug degradation by pH-associated deactivation and by enzymes, thus resulting in an efficient therapy [ 153 ]. TDDSs are non-invasive in comparison to parenteral administration, remaining relatively painless, therefore enhancing patient compliance and acceptability [ 152 ].…”

Section: Chitosan Based Nanomaterials As Transdermal Nanocarriersmentioning

confidence: 99%

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

et al. 2021

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In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on chitosan (CS) or chitosan derivatives are broadly investigated as promising nanocarriers due to their biodegradability, good biocompatibility, non-toxicity, low immunogenicity, great versatility and beneficial biological effects. CS, either alone or as composites, are suitable substrates in the fabrication of different types of products like hydrogels, membranes, beads, porous foams, nanoparticles, in-situ gel, microparticles, sponges and nanofibers/scaffolds. Currently, the CS based nanocarriers are intensely studied as controlled and targeted drug release systems for different drugs (anti-inflammatory, antibiotic, anticancer etc.) as well as for proteins/peptides, growth factors, vaccines, small DNA (DNAs) and short interfering RNA (siRNA). This review targets the latest biomedical approaches for CS based nanocarriers such as nanoparticles (NPs) nanofibers (NFs), nanogels (NGs) and chitosan coated liposomes (LPs) and their potential applications for medical and pharmaceutical fields. The advantages and challenges of reviewed CS based nanocarriers for different routes of administration (oral, transmucosal, pulmonary and transdermal) with reference to classical formulations are also emphasized.

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“…It appears to be an effective mode of drug delivery to systemic circulation without pain by applying it on to intact skin. There has been a brisk increase in interest and research in the field of transdermal delivery due to following advantages: 8,9 • Minimization of fluctuation in peak plasma concentration as in case of the oral and parenteral route, • No issue of hepatic first-pass metabolism (presystemic metabolism), • Reduced dosing frequency and a dose of drug, • Sustained effect, • Bioavailability improvement Owing to these benefits, TDDS market is expected to expand by 2025 up to $95.57 billion. 10 In 1979, scopolamine TDDS became the first of its kind to get United States Food and Drug Administration (USFDA) approval followed by nicotine patches in 1984.…”

Section: Review Article Transdermal Drug Delivery System (Tdds)mentioning

confidence: 99%

Transdermal Patches: State of the Art

Sharma¹,

Thakur²,

Kaur³

et al. 2020

ijddt

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There is a considerable increase in preference for use of transdermal patches over conventional dosage forms owing to the advantages it possesses over them. Transdermal delivery of drugs has undergone rapid advancements through techniques like electroporation, microneedles, iontophoresis etc. This review is aimed at providing deep insight into transdermal technology and its types. An overview of the present market size of transdermal patches along with future prospects has been discussed. Transdermal products being manufactured by Indian pharmaceuticals also has been presented. Various components of transdermal patches being explored have been elaborated. After studying this review, it could be concluded that there are huge prospects for transdermal systems, and research aimed at the delivery of sparingly soluble drugs needs to be done to overcome limitations.

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Controlled release of testosterone by polymer-polymer interaction enriched organogel as a novel transdermal drug delivery system: Effect of limonene/PG and carbon-chain length on drug permeability

Cited by 23 publications

References 39 publications

Organogel: A Propitious Carman in Drug Delivery System

Organogel: A Propitious Carman in Drug Delivery System

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

Transdermal Patches: State of the Art

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