Controlled release of titanocene into the hybrid nanofibrous scaffolds to prevent the proliferation of breast cancer cells

Laiva, Ashang Luwang; Venugopal, Jayarama Reddy; Karuppuswamy, Priyadharsini; Navaneethan, Balchandar; Góra, Aleksander; Ramakrishna, Seeram

doi:10.1016/j.ijpharm.2015.02.025

Cited by 26 publications

(15 citation statements)

References 36 publications

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“…However, prolonged use of LBP may also lead to abnormalities in the blood system ( 4 , 5 ). Therefore, research has focused on reducing the dosage of chemotherapeutic drugs, while improving the local drug concentration, as well as on the reduction of side effects ( 6 ). The development of a targeted drug with low toxicity, high efficiency and high specificity is critical for the treatment of BC.…”

Section: Introductionmentioning

confidence: 99%

Antitumor effects of carbon nanotube‑drug complex against human breast cancer cells

et al. 2018

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To improve the bio-solubility and sustained-release properties of a carbon nanotube (CNT)-drug complex, the present study used a hydrophilic polymer, polyethylene glycol (PEG), and β-estradiol (E2), which targets the estrogen receptor in human breast cancer cells (HBCCs), to modify CNTs carrying lobaplatin (LBP) to form E2-PEG-CNT-LBP. The in vitro inhibitory effects against HBCCs and the in vivo pharmacological effect of the complex on heart, liver and kidney tissues were also evaluated. The results indicated that the inhibitory effects of this complex against HBCCs reached 80.44% within 72 h. A blood biochemical test of normal mice indicated that this complex reduced platelet counts, while aspartate aminotransferase levels were increased compared with those in the control group. Histopathological analysis revealed no obvious adverse effects on the heart, liver and kidneys. The in vivo results indicated that the novel E2-PEG-CNT-LBP complex had no obvious toxic effects while exhibiting sustained-release properties. The clearance of E2-PEG-CNT-LBP by non-specific uptake systems was delayed and its clearance was increased compared with LBP alone.

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Section: Introductionmentioning

confidence: 99%

Antitumor effects of carbon nanotube‑drug complex against human breast cancer cells

et al. 2018

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“…For instance, Laiva et al . 28 , reported 70% release of titanocene dichloride from electrospun polycaprolactone (PCL)/silk fibroin (SF) nanofibers in 2 days, while the released concentration reached the maximum in 6 days. In another work, Sasikala et al .…”

Section: Resultsmentioning

confidence: 99%

Salinomycin-loaded Nanofibers for Glioblastoma Therapy

Norouzi

Abdali

Liu

et al. 2018

Sci Rep

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Salinomycin is an antibiotic that has recently been introduced as a novel and effective anti-cancer drug. In this study, PLGA nanofibers (NFs) containing salinomycin (Sali) were fabricated by electrospinning for the first time. The biodegradable PLGA NFs had stability for approximately 30 days and exhibited a sustained release of the drug for at least a 2-week period. Cytotoxicity of the NFs + Sali was evaluated on human glioblastoma U-251 cells and more than 50% of the treated cells showed apoptosis in 48 h. Moreover, NFs + Sali was effective to induce intracellular reactive oxygen species (ROS) leading to cell apoptosis. Gene expression studies also revealed the capability of the NFs + Sali to upregulate tumor suppressor Rbl1 and Rbl2 as well as Caspase 3 while decreasing Wnt signaling pathway. In general, the results indicated anti-tumor activity of the Sali-loaded NFs suggesting their potential applications as implantable drug delivery systems in the brain upon surgical resection of the tumor.

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“…A polymeric NPs formulation of curcumin (NanoCurc) was designed and studied to significantly attenuate incidence of mammary tumors in a rodent chemical carcinogenesis model, confirming its breast cancer chemoprevention potential in at-risk populations (Chun et al, 2012). In another study, the composite polycaprolactone/silk fibroin nanofibrous scaffolds loaded with titanocene were developed and reported to have potential for preventing the proliferation of breast cancer cells (Laiva et al, 2015). Interestingly, dietary soy isoflavones (genistein, etc.)…”

Section: Breast Cancermentioning

confidence: 98%

Cancer Chemoprevention Using Nanotechnology-Based Approaches

et al. 2020

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Cancer research in pursuit of better diagnostic and treatment modalities has seen great advances in recent years. However, the incidence rate of cancer is still very high. Almost 40% of women and men are diagnosed with cancer during their lifetime. Such high incidence has not only resulted in high mortality but also severely compromised patient lifestyles, and added a great socioeconomic burden. In view of this, chemoprevention has gained wide attention as a method to reduce cancer incidence and its relapse after treatment. Among various stems of chemoprevention research, nanotechnology-based chemoprevention approaches have established their potential to offer better efficacy and safety. This review summarizes recent advances in nanotechnology-based chemoprevention strategies for various cancers with emphasis on lung and bronchial cancer, colorectal, pancreatic, and breast cancer and highlights the unmet needs in this developing field towards successful clinical translation.

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Controlled release of titanocene into the hybrid nanofibrous scaffolds to prevent the proliferation of breast cancer cells

Cited by 26 publications

References 36 publications

Antitumor effects of carbon nanotube‑drug complex against human breast cancer cells

Antitumor effects of carbon nanotube‑drug complex against human breast cancer cells

Salinomycin-loaded Nanofibers for Glioblastoma Therapy

Cancer Chemoprevention Using Nanotechnology-Based Approaches

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