Controlled Study of Intravenous IgG Therapy for HIV-Infected Adults with Recurrent Bacterial Infections

Williams, P.E.; Thompson, C.; Yap, P.L.; Brettle, R.P.

doi:10.1159/000461264

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“…The use of IVIG in HIV‐infected adults is less well characterized and appears more dubious than the case with children 33‐35 . The results of studies of IVIG in adult HIV patients are inconsistent and none of the studies that have shown benefit of IVIG in preventing serious bacterial infections in HIV‐infected adults has been double‐blind or placebo‐controlled.…”

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confidence: 99%

Current usage of intravenous immune globulin and the rationale behind it: the Massachusetts General Hospital data and a review of the literature

2006

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confidence: 99%

Current usage of intravenous immune globulin and the rationale behind it: the Massachusetts General Hospital data and a review of the literature

2006

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“…We speculate that IVIG may have prevented many infections. It is well documented that IVIG decreases the rate of viral and bacterial infections in children with AIDS (Moffenson & Moye, 1993;Williams et al, 1991). Persistent B19 parvovirus associated anaemia in our patient was treated effectively with long-term maintenance IVIG.…”

Section: Discussionmentioning

confidence: 51%

Management of persistent B19 parvovirus infection in AIDS

et al. 1995

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An HIV+ 26-year-old white man with a CD4 count of 0.06 x 10(9)/l was found to have red blood cell aplasia secondary to B19 parvovirus infection. Regular infusions of intravenous immunoglobulin (IVIG) were begun and resulted in marked reticulocytosis and correction of anaemia. The patient has been followed for over 4 years and has become anaemic and reticulocytopenic whenever IVIG was interrupted. Serial dot blot analysis of the patient's sera for B19 parvovirus DNA showed absence of DNA immediately following IVIG treatments but reappearance within 3-6 weeks. Regular IVIG was effective in controlling but not eradicating B19 parvovirus infection in this HIV+ patient.

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Controlled Study of Intravenous IgG Therapy for HIV-Infected Adults with Recurrent Bacterial Infections

Cited by 2 publications

References 5 publications

Current usage of intravenous immune globulin and the rationale behind it: the Massachusetts General Hospital data and a review of the literature

Current usage of intravenous immune globulin and the rationale behind it: the Massachusetts General Hospital data and a review of the literature

Management of persistent B19 parvovirus infection in AIDS

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