Controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules with a PEGylated nanocore and their application for fluorescence detection of target protein

Feng, Xingjia; Jin, Siyu; Li, Dongru; Fu, Guoqi

doi:10.1039/d2ra02298b

RSC Adv.

2022

DOI: 10.1039/d2ra02298b

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Controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules with a PEGylated nanocore and their application for fluorescence detection of target protein

Xingjia Feng

Siyu Jin

Dongru Li

et al.

Abstract: Surface epitope imprinting over the one side of Janus SiO2 NPs via ATRP affords open-mouthed epitope-imprinted nanocapsules with imprinted cavities of homogeneous orientation and good accessibility for fluorescence detection of target protein.

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Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers

Hong,

Wang,

Gao

et al. 2024

Molecules

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Molecular imprinting has emerged as an important and practical technology to create economical and stable synthetic mimics of antibodies and enzymes. It has already found a variety of important applications, such as affinity separation, chemical/biological sensing, disease diagnostics, proteomics, bioimaging, controlled drug release, and catalysis. In the past decade, significant breakthroughs have been made in non-covalently imprinted polymers, from their synthesis through to their applications. In terms of synthesis, quite a few versatile and facile imprinting approaches for preparing MIPs have been invented, which have effectively solved some key issues in molecular imprinting. Additionally, important applications in several areas, such as sensors, proteomics and bioimaging, have been well demonstrated. In this review, we critically and comprehensively survey key recent advances made in the preparation of non-covalently imprinted polymers and their important applications. We focus on the state-of-art of this technology from three different perspectives: fundamentals, synthetic strategies, and applications. We first provide a fundamental basis for molecular imprinting technologies that have been developed, which is extremely helpful for establishing a sound understanding of the challenges in molecular imprinting. Then, we discuss in particular the major breakthroughs within the last ten years (2014–2024), with emphasis on new imprinting approaches, what strengths the breakthroughs can provide, and which new applications the properties of the prepared non-covalently imprinted polymers are fit for.

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Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers

Hong,

Wang,

Gao

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

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Controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules with a PEGylated nanocore and their application for fluorescence detection of target protein

Abstract: Surface epitope imprinting over the one side of Janus SiO2 NPs via ATRP affords open-mouthed epitope-imprinted nanocapsules with imprinted cavities of homogeneous orientation and good accessibility for fluorescence detection of target protein.

Cited by 1 publication

References 61 publications

Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers

Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers

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