Controlled synthesis of up-conversion luminescent Gd/Tm-MOFs for pH-responsive drug delivery and UCL/MRI dual-modal imaging

Liu, Yana; Zhang, Cheng; Xu, Chen; Lin, Caixue; Sun, Keke; Wang, Jie; Chen, Xueli; Li, Ling; Whittaker, Andrew K.; Xu, Hai‐Bing

doi:10.1039/c8dt02436g

Cited by 35 publications

(21 citation statements)

References 42 publications

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“…Doxorubicin (DOX) is a widely reported anticancer drug effective on several types of cancer including breast cancer. − DOX is a fluorescent molecule and therefore is suitable for in vitro imaging studies. The sterically unhindered ketone functionality of DOX allows for the attachment to the fluorinated copolymers via a pH-dependent hydrolytically degradable hydrazone bond without the need for further modification .…”

Section: Results and Discussionmentioning

confidence: 99%

Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy

et al. 2020

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Incorporation of fluorinated moieties in polymeric nanoparticles has been shown in many instances to increase their uptake by living cells and, hence, has proven to be a useful approach to enhancing delivery to cells. However, it remains unclear how incorporation of fluorine affects critical transport processes, such as interactions with membranes, intracellular transport, and tumor penetration. In this study, we investigate the influence of fluorine on transport properties using a series of rationally designed poly(oligo(ethylene glycol) methyl ether acrylate)-block-perfluoropolyether (poly(OEGA) m -PFPE) copolymers. Copolymers with different fluorine contents were prepared and exhibit aggregate in solution in a manner dependent on the fluorine content. Doxorubicin-conjugated poly(OEGA)20-PFPE nanoparticles with lower fluorine content exist in solution as unimers, leading to greater exposure of hydrophobic PFPE segments to the cell surface. This, in turn, results in greater cellular uptake, deeper tumor penetration, as well as enhanced therapeutic efficacy compared to that with the micelle-state nanoaggregates (poly(OEGA)10-PFPE and poly(OEGA)5-PFPE) with higher fluorine content but with less PFPE exposed to the cell membranes. Our results demonstrate that the aggregation behavior of these fluorinated polymers plays a critical role in internalization and transport in living cells and 3D spheroids, providing important design criteria for the preparation of highly effective delivery agents.

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Section: Results and Discussionmentioning

confidence: 99%

Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy

et al. 2020

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“…In previous years, the development of strategies focusing on photon Up-Conversion (UC) processes for photothermal therapy [ 29 , 30 ], cell imaging [ 31 , 32 ] and pH-responsive [ 33 , 34 ] treatments have received great attention [ 35 ]. These UC processes are based on the absorption of photons leading to the emission of another photon whose energy is higher than the energy of the absorbed photons.…”

Section: Introductionmentioning

confidence: 99%

Controlled Synthesis of Up-Conversion NaYF4:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy

et al. 2021

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Up-Conversion materials have received great attention in drug delivery applications in recent years. A specifically emerging field includes the development of strategies focusing on photon processes that promote the development of novel platforms for the efficient transport and the controlled release of drug molecules in the harsh microenvironment. Here, modified reaction time, thermal treatment, and pH conditions were controlled in the synthesis of NaYF4:Yb,Tm up-converted (UC) material to improve its photoluminescence properties. The best blue-emission performance was achieved for the UC3 sample prepared through 24 h-synthesis without thermal treatment at a pH of 5, which promotes the presence of the β-phase and smaller particle size. NaYF4:Yb,Tm has resulted in a highly efficient blue emitter material for light-driven drug release under near-IR wavelength. Thus, NaYF4:Yb,Tm up-converted material promotes the N-O bond cleavage of the oxime ester of Ciprofloxacin (prodrug) as a highly efficient photosensitized drug delivery process. HPLC chromatography and transient absorption spectroscopy measurements were performed to evaluate the drug release conversion rate. UC3 has resulted in a very stable and easily recovered material that can be used in several reaction cycles. This straightforward methodology can be extended to other drugs containing photoactive chromophores and is present as an alternative for drug release systems.

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“…5−12 The adjustment of constituent, dimension, and morphology of RE-MOF materials is of great significant to meet the requirements of their various multifunctional luminescence applications. 13,14 Especially, different morphologies of RE-MOFs generally exhibit different luminescent properties. 15 Therefore, it is highly desirable to open a new feasible way to modulate the crystallinity and morphology of RE-MOFs to afford them improved luminescent properties for potential use in optical applications.…”

Section: ■ Introductionmentioning

confidence: 99%

Synergetic Effect of Tetraethylammonium Bromide Addition on the Morphology Evolution and Enhanced Photoluminescence of Rare-Earth Metal–Organic Frameworks

Liu

Han

et al. 2020

Inorg. Chem.

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Controlled synthesis of rare-earth metal−organic frameworks (RE-MOFs) is of great significance to match their emerging multifunctional luminescence applications. Herein, we propose a green and general solventfree synthetic strategy for the adjustment of morphology and dimension of various RE-MOFs (RE = Eu, Tb, Er, Dy, Y, Tm) by using a tetraethylammonium bromide-assisted thermal-heating method. These selfassembled RE-MOF materials possess controllable morphologies and hierarchical structures while retaining the structural topology of MIL-78, proving that the strategy is a feasible and effective way in opening up largescale synthesis of RE-MOFs. It is further found that the tetraethylammonium could be carbonized into carbon dots and encapsulated in Eu/Tb-MIL-78 to enhance the fluorescence emission intensities significantly, making the hierarchical Eu/Tb-MIL-78 MOF materials good candidates for the latent fingerprints recognition application. This work provides a novel strategy for effectively controlling the morphology and dimension of RE-MOFs materials with enhanced photoluminescence and has great potential in their scaling-up syntheses and exploring the new luminescence applications.

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Controlled synthesis of up-conversion luminescent Gd/Tm-MOFs for pH-responsive drug delivery and UCL/MRI dual-modal imaging

Cited by 35 publications

References 42 publications

Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy

Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy

Controlled Synthesis of Up-Conversion NaYF4:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy

Synergetic Effect of Tetraethylammonium Bromide Addition on the Morphology Evolution and Enhanced Photoluminescence of Rare-Earth Metal–Organic Frameworks

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