Controlled synthesis of zinc-metal organic framework microflower with high efficiency electrochemiluminescence for miR-21 detection

Wang, Xiaoyan; Wang, Xue; Hu, Congyi; Guo, Wei; Wu, Xianguo; Chen, Gaoxu; Dai, Wenjie; Zhen, Shu Jun; Huang, Chengzhi; Li, Yuanfang

doi:10.1016/j.bios.2022.114443

Cited by 25 publications

(16 citation statements)

References 45 publications

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“…Based on the aggregation-induced ECL emission of ligands and silver-catalysis toward S 2 O 8 2– , an ERET biosensor with a AgMOF donor and black hole quencher-2 acceptor was assembled for miRNA-107 detection . Furthermore, utilizing 6-carboxy-4′,5′-dichloro-2′,7′-dimethoxyfluorescein as the receptor, an ERET biosensor was constructed based on a mixed ligand MOF donor composed of the luminophore and DEAEA co-reactant for sensitive detection of miR-21 without additional co-reactant . In addition, due to the surface plasmon resonance effect of Au–Pt nanorods, a high performance ECL platform composed of a Eu-MOF as luminophore and Au–Pt bimetallic nanorods as plasma source exhibits 2.6-fold enhancement compared to free Eu-MOF …”

Section: Mechanisms Of Ecl Enhancementmentioning

confidence: 99%

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Luo

Zhu

et al. 2023

Acc. Chem. Res.

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Metrics & MoreArticle Recommendations CONSPECTUS: Electrochemiluminescence (ECL) is a powerful transduction technique, which depends critically on the formation of the excited emitter through the charge transfer between the electrochemical reaction intermediates of the emitter and the co-reactant/emitter. The exploration of ECL mechanisms for conventional nanoemitters is limited due to the uncontrollable charge transfer process. With the development of molecular nanocrystals, reticular structures such as metal−organic frameworks (MOFs) and covalent organic frameworks (COFs) have been utilized as atomically precise semiconducting materials. The long-range order in crystalline frameworks and the tunable coupling among building blocks promote the quick development of electrically conductive frameworks. Especially, the reticular charge transfer can be regulated by both interlayer electron coupling and intralayer topology-templated conjugation. By modulating intramolecular or intermolecular charge mobility, reticular structures could serve as promising candidates for enhancing ECL. Thus, reticular crystalline nanoemitters with different topologies provide a confined platform to understand ECL fundamentals for designing next-generation ECL devices.Aiming at exploring the mechanism of ECL emission, our group has developed a series of ECL nanoemitters as well as enhancement strategies of ECL emission in the past 20 years. A series of water-soluble ligandcapped quantum dots were introduced as ECL nanoemitters to create sensitive analytical methods for detecting and tracing biomarkers. The functionalized polymer dots were also designed as ECL nanoemitters for imaging of membrane proteins with signal transduction strategies of dual resonance energy transfer and dual intramolecular electron transfer. To decode the ECL fundamental and enhancement mechanisms, an electroactive MOF with accurate molecular structure was first constructed with two redox ligands as a highly crystallized ECL nanoemitter in aqueous medium. Through the mixed-ligand approach, luminophores and co-reactants were integrated into one MOF structure for self-enhanced ECL. Furthermore, several donor−acceptor COFs were developed as efficient ECL nanoemitters with tunable intrareticular charge transfer. The atomically precise structure of conductive frameworks established clear correlations between the structure and charge transport in these materials. Therefore, reticular materials as crystalline ECL nanoemitters have demonstrated both proof of concept and mechanistic innovation.In this Account, taking advantage of reticular materials with accurate molecular structure, we survey the design of the electroactive reticular materials including MOFs and COFs as crystalline ECL nanoemitters at the molecular level. The enhancement mechanisms of ECL emission of various topology frameworks are discussed via the regulation of reticular energy transfer and charge transfer and the accumulation of anion/cation radicals. Our perspective on the reticular ECL nanoemitters is ...

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Section: Mechanisms Of Ecl Enhancementmentioning

confidence: 99%

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Luo

Zhu

et al. 2023

Acc. Chem. Res.

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“…37 Our group successively prepared two kinds of Zn-MOF, respectively realizing doublesignal annihilation ECL 38 and self-enhanced ECL. 39 Based on the above, MOF has good prospects in the field of ECL, especially in coreactant-free systems. N-2-Hydroxyethylpiperazine-N′-ethane-sulfonic acid (HEPES) is a typical buffer substance, which has good water solubility and biocompatibility.…”

Section: ■ Introductionmentioning

confidence: 98%

“…Shan’s team proposed MOF-525-Zn promoting singlet oxygen ( 1 O 2 ) ECL emission . Our group successively prepared two kinds of Zn-MOF, respectively realizing double-signal annihilation ECL and self-enhanced ECL . Based on the above, MOF has good prospects in the field of ECL, especially in coreactant-free systems.…”

Section: Introductionmentioning

confidence: 99%

High-Efficiency Aluminum–Metal Organic Framework/HEPES Electrochemiluminescence System for Ultrasensitive Detection of HBV DNA

et al. 2023

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In this work, a novel aluminum metal–organic framework (Al-MOF)/N-2-hydroxyethylpiperazine-N′-ethane-sulfonic acid (HEPES) system with an excellent electrochemiluminescence (ECL) property was developed. First, Al-MOF was successfully synthesized through a one-pot solvothermal method by using 9,10-di(p-carboxyphenyl)anthracene (DPA) as the organic luminescence ligand and Al3+ as the metal node. Compared with DPA, Al-MOF showed high ECL intensity and excellent stability without an additional coreactant in the HEPES buffer. The corresponding ECL mechanism was studied in detail, verifying HEPES was not only the buffer in the system but also the coreactant of Al-MOF. In particular, the system of Al-MOF/HEPES showed a high ECL efficiency of 30.0%, taking the Ru(bpy)3 2+ system as the standard. In addition, the ECL signal of Al-MOF was effectively quenched by dopamine (DA). The biosensor for HBV DNA detection was constructed through the ECL signal on–off–on mode of DNA specific recognition integrated with the DNA walker signal amplification strategy. The ultrasensitive detection for HBV DNA was achieved with a linear range of 100 aM to 10 pM and a limit of detection (LOD) of 62.1 aM. This work proposed a high-efficiency Al-MOF/HEPES system, providing a new viewpoint for a coreactant-free system in the field of ECL.

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“…Electrochemiluminescence (ECL), a form of energy relaxation, was triggered by the electrochemical stimulation, which was attracting increasing interest in a variety of areas, − such as clinical diagnosis, environmental regulation, food analysis, and drug detection on account of low background, high sensitivity, and excellent controllability. − In the coreactant ECL system, the coreactant was indispensable to improve the ECL efficiency of the emitter. − However, the reaction between the external coreactant and emitter in the traditional coreactant ECL system had certain disadvantages of slow electron transfer speed and low ECL efficiency, limiting the improvement of ECL strength. , Therefore, it was particularly important to explore an efficient ECL emitter to avoid the electron transmission obstruction and large energy loss between the emitter and coreactant in solution. On account of the π–π stacking and electrostatic interactions as well as the stimulation of electrical activity by heteropolar B–N bonding, boron carbon nitride nanosheets (BCN NSs) exhibited striking performance such as extraordinary chemical stability, excellent adsorption, and impressive oxygen reduction reaction catalysis. − Moreover, the electronic tunneling among the ultrathin BCN NSs’ interlamination could realize faster electron transfer, which was conducive to the rapid and effective intramolecular reaction.…”

Section: Introductionmentioning

confidence: 99%

Boron Carbon Nitride Nanosheets-Ru Nanocomposite Self-Enhancement Electrochemiluminescence Emitter with a Three-Dimensional DNA Network Structure as a Signal Amplifier for Ultrasensitive Detection of TK1 mRNA

Zhang

Yuan

2022

Anal. Chem.

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In this study, a neoteric self-enhanced nanocomposite boron carbon nitride nanosheets (BCN NSs)-Ru obtained by chemical crosslinking between boron carbon nitride nanosheets (BCN NSs) and tris (4,4′-dicarboxylicacid-2,2′-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy) 3 Cl 2 ) was used as an emitter to build an electrochemiluminescence (ECL) biosensor for ultrasensitive detection of the cancer marker human thymidine kinase 1 (TK1) mRNA. Importantly, the self-enhanced BCN NSs-Ru could exhibit strong ECL emission because boron radicals and amine groups derived from BCN NSs could significantly enhance the ECL response of Ru(dcbpy) 3 Cl 2 , which avoided the defects of the long electron transfer path and large energy loss between the emitter and coreactant in the traditional coreaction ECL system. Impressively, in the presence of target TK1 mRNA, three-dimensional DNA network structure-labeled numerous ferrocene probes could be assembled to quickly quench the ECL signal of BCN NSs-Ru, resulting in improved biosensor sensitivity. The obtained "on−off" biosensor showed excellent stability and high sensitivity with a detection limit of 32.3 aM. In general, the developed strategy provided a new biosensing way for ultrasensitive detection of biomolecules in early disease diagnosis.

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Controlled synthesis of zinc-metal organic framework microflower with high efficiency electrochemiluminescence for miR-21 detection

Cited by 25 publications

References 45 publications

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

High-Efficiency Aluminum–Metal Organic Framework/HEPES Electrochemiluminescence System for Ultrasensitive Detection of HBV DNA

Boron Carbon Nitride Nanosheets-Ru Nanocomposite Self-Enhancement Electrochemiluminescence Emitter with a Three-Dimensional DNA Network Structure as a Signal Amplifier for Ultrasensitive Detection of TK1 mRNA

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