Controlled transdermal iontophoresis by ion-exchange fiber

Jaskari, Tarja; Vuorio, Marja; Kontturi, Kyösti; Urtti, Arto; Manzanares, José A.; Hirvonen, Jouni

doi:10.1016/s0168-3659(00)00204-2

Cited by 76 publications

(49 citation statements)

References 18 publications

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“…As a result, the concentration of the drug available at the site of absorption decreases. Some of the drugs undergo metabolism in the GIT and the resulting metabolites might be toxic and dangerous [18]. When the dose is administered transdermally, the drug will circumvent the first pass effect.…”

Section: Textile Slow Release Systemsmentioning

confidence: 99%

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Impact and Scope of Intelligent Textiles in Health Care

Shende¹,

Desai²

2017

J Bioequiv Availab

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Section: Textile Slow Release Systemsmentioning

confidence: 99%

“…Ion-exchangers show specificity and this factor is used in controlling the exchanges. Commercial products of ion exchange fibers used for drug delivery are available such as 'Smopex' [18].…”

Section: Ion Exchange Fibersmentioning

confidence: 99%

Impact and Scope of Intelligent Textiles in Health Care

Shende¹,

Desai²

2017

J Bioequiv Availab

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“…So some new transdermal methods, for example physical and pharmaceutics, are developed [1][2][3]. Penetration enhancers are the first choice to improve transdermal absorption though iontophoresis [4], sonophoresis[5~6], microneedles [7] and thermalphoresis [8] Recently, the United States have forbidden dimethyl sulfoxide because its high concentration could cause erythema, blister and irreversible damage on skin. One of the main defects of synthesized PE is short of specificity, can promote skin to absorb other vehicle components, so that any impurity can be absorbed by the skin and enter the blood circulation.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Performance of A Novel Penetration Enhancer

Wu¹,

Tang²,

Shen³

et al. 2017

Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

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Abstract-Preparation and percutaneous absorption of 2-methyl-2-perfluoro-2′-methyl-3′-oxoca-proyloxyl ethoxycarbonyl ethylmethyldipolyethoxylsilicane (V) were investigated. V was synthesized from 2-perfluoro-2′-methyl-3′-oxocaproyloxylethyl methacrylate and methyldichlorosilicane by hydrosilication, then by alcoholysis with polyglycol, and was characterized by FTIR and MS. The penetration percentage of diclofenac sodium in different solutions of 2% 1-menthol, 0.5% V, 2% 1-menthol-0.5% V and 2% azone were respectively determined with improved Franz equipment and using rat skin as transderma barrier. The enhancement ratios were 3.11, 1.19, 5.46 and 6.21, respectively. V with 1-menthol could improve the trasdermal amount of diclofenac sodium, especially, but sole V express bad performance for it.

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“…Recently, increasing attention has been focused on ion exchange fibers due to their advantage over ion exchange resins such as more rapid and efficient ion-exchange performance, more efficient drug loading and release into/from ion exchange fibers, easier incorporation of large-sized molecules and better control of loading/release [4,5]. There are only a few studies that report the pharmaceutical uses of ion-exchange fibers such as gastromucoadhesive delivery system [6] and transdermal delivery system [7,8].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Cationic Exchange Polystyrene Nanofibers for Drug Delivery

Akkaramongkolporn¹,

Opanasopit

2014

Trop. J. Pharm Res

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Purpose: To prepare polystyrene nanofiber ion exchangers (PSNIE) with surface cation exchange functionality using a new method based on electrospinning and also to optimize crosslinking and sulfonation reactions to obtain PSNIE with maximum ion exchange capacity (IEC). Method: The nanofibers were prepared from 15% w/v polystyrene solution in dimethylacetamide (DMAc) containing 0.025 %w/v tetrabutylammonium bromide (TBAB) using electrospinning technique, followed by crosslinking with sulfuric acid/formaldehyde in a ratio ranging from 100/0 to 50/50 v/v and sulfonation in sulfuric acid. Degree of crosslinking was determined as the amount of fibers that remained in dichloromethane. The morphology and diameter of the fibers were evaluated by scanning electron microscopy (SEM) while IEC of PSNIE was performed by salt splitting titration. Results: PSNIE crosslinked with a sulfuric acid/formaldehyde ratio of 90/10 with 0.1 %w/v silver sulfate for 10 min at 70  C and sulfonated in 98 % sulfuric acid with 0.2 %w/v silver sulfate as the catalyst at 100  C for 30 min showed a maximum IEC of 3.21 meq/g-dry-PSNIE. Increase in sulfonation temperature caused the IEC of PSNIE to increase due to faster sulfonation. It was observed that the higher the temperature the faster the rate of sulfonation reaction. The diameter of the fibers after sulfonation was 404 ± 42 nm. Conclusion: These results indicate that PSNIE can be successfully prepared by electrospinning. Furthermore, cationic drug can be loaded onto the novel PSNIE for controlled release delivery.

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Controlled transdermal iontophoresis by ion-exchange fiber

Cited by 76 publications

References 18 publications

Impact and Scope of Intelligent Textiles in Health Care

Impact and Scope of Intelligent Textiles in Health Care

Synthesis and Performance of A Novel Penetration Enhancer

Fabrication of Cationic Exchange Polystyrene Nanofibers for Drug Delivery

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