Controlled transdermal iontophoresis of sulfosalicylic acid from polypyrrole/poly(acrylic acid) hydrogel

Chansai, Phithupha; Sirivat, Anuvat; Niamlang, Sumonman; Chotpattananont, Datchanee; Viravaidya-Pasuwat, Kwanchanok

doi:10.1016/j.ijpharm.2009.07.019

Cited by 65 publications

(41 citation statements)

References 27 publications

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“…In addition, its biocompatibility and renewable resource are more promising as compared to other synthetic polymers. Thus, the above results confirm that the D of the drug in the TDDs depends on and can be controlled by many factors: the chemical composition of the drug; the drug molecular weight; the drug size; the polymer matrix; the drug-matrix interaction; and the experimental set up [30].…”

Section: Effect Of Electrode Polaritysupporting

confidence: 65%

“…On the other hand, the D of FA is decreased as expected since it is a cationic drug. Figure 11b shows the comparison of the D of Polyacrylamide (PAAM) [29], Polyacrylic acid (PAA) [30], and Polyvinyl alcohol (PVA) [6] hydrogels. The D of PAAM is higher than the PAA and PVA hydrogels, respectively with and without electric field stimulation.…”

Section: Effect Of Electrode Polaritymentioning

confidence: 99%

“…So, this creates the additional driving force between the negatively charges of the drug (salicylic acid) and of the carboxylate groups in the PAAM matrix [31]. However the diffusion coefficient of the Ca-Alg hydrogel is many orders of magnitude higher than those of PAA and PVA, either with or without electric field stimulation because of the existing hydrogen bond of the anionic drug with PAA and PVA are relatively stronger interaction [6,30]. Table 4 shows the drug size, mesh size and, the D of the drugs on Ca-Alg, poly(vinyl alcohol) (PVA), Polyacrylic acid (PAA) and Polyacrylamide (PAAM) hydrogels at various conditions.…”

Section: Effect Of Electrode Polaritymentioning

confidence: 99%

“…The D of chlorpheniramine decreased with increasing alginate content since the increase in the alginate content decreased the rate of water penetration into the gel leading to a more rigid gel which retarded the drug release. Juntanon et al [6], Chansai et al [30], and Niamlang et al [29] studied the Ds of anionic drugs as sulfosalicylic acid [6,30] and salicylic acid [29] on PVA, PAA, and PAAM hydrogels, respectively. They investigated that the diffusion of the anionic drug occurred through the drug diffusing out of the matrix by the concentration gradient in the absence of current, and the electrophoresis of the anionic drug under applied current.…”

Section: Effect Of Electrode Polaritymentioning

confidence: 99%

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Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel

Paradee

Sirivat

Niamlang

et al. 2012

J Mater Sci: Mater Med

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The drug release characteristics of calcium alginate hydrogels, (Ca-Alg), under an electric field assisted transdermal drug delivery system were systematically investigated. The Ca-Alg hydrogels were prepared by the solution-casting using CaCl(2) as a crosslinking agent. The diffusion coefficients and the release mechanism of the anionic model drugs, benzoic acid and tannic acid, and a cationic model drug, folic acid on the Ca-Alg hydrogels were determined and investigated using a modified Franz-Diffusion cell in an MES buffer solution of pH 5.5, at a temperature of 37°C, for 48 h. The influences of the crosslinking ratio, -the mole of the crosslinking agent to the mole of the alginate monomer-mesh size, model drug size, drug charge, electric field strength, and electrode polarity were systematically studied. The drug diffusion coefficient decreased with an increasing crosslinking ratio and drug size for all of the model drugs. The drug diffusion coefficient is precisely controlled by an applied electric field and the electrode polarity depending on the drug charge, suitable for a tailor-made transdermal drug delivery system.

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Section: Effect Of Electrode Polaritysupporting

confidence: 65%

Section: Effect Of Electrode Polaritymentioning

confidence: 99%

Section: Effect Of Electrode Polaritymentioning

confidence: 99%

Section: Effect Of Electrode Polaritymentioning

confidence: 99%

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Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel

Paradee

Sirivat

Niamlang

et al. 2012

J Mater Sci: Mater Med

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“…Salicylic acid and its derivatives like sulphosalicylic acid, acetyl salicylic acid are popular model drugs for iontophoretic studies through a wide range polymeric hydrogels based on synthetic and natural polymers [41][42][43][44][45] This paper describes development of Polymeric hydrogel patches doped with Salicylic acid and Potassium Salt of Acetyl Salicylic acid. The latter is commercially known as Disprin, a commonly used over-the-counter analgesic and antipyretic in India as well as an inhibitor of thromboxane prostaglandins).…”

Section: Introductionmentioning

confidence: 99%

Iontophoretic study on Salicylic acid and Disprin loaded polymer hydrogels

Kanjilal

Dasgupta

Banthia

2011

Int J Plast Technol

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The study describes iontophoretic release of Salicylic acid and Potassium Salt of Acetyl Salicylic acid which is commonly known as the analgesic and thromboxane prostaglandins inhibitor, Disprin, from hydrogel patches based on Poly (vinyl alcohol), Poly (vinyl acetate-co-crotonic acid) & Poly (vinyl pyrrolidone). The experiment utilized a modified Franz cell for iontophoresis with a brine filled receptor chamber and employed Visible Colorimetry as the technique for estimation. It can be concluded that the composition of the hydrogel matrix has a direct bearing on the diffusion of the drugs. The hydrogel composition determines the extent of crosslinking, crystallinity, availability of hydrophilic groups, polymer-water interaction and hence the water take up. The ability of a drug delivery hydrogel system to control solute transport and release depends highly on the water content and water movement within the polymeric structure. The study was carried out keeping in view the eventual development of an alternative electrically controlled delivery mechanism of drugs without adverse gastrointestinal systemic ramifications.

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