Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF

Osorio-Toribio, Génesis; Velásquez‐Hernández, Miriam de J.; Mileo, Paulo G. M.; Zárate, J. Antonio; Aguila-Rosas, Javier; Leyva-Gómez, Gerardo; Sánchez-Sánchez, Roberto; Magaña, Jonathan J.; Pérez-Díaz, Mario Alberto; Lázaro, Isabel Abánades; Forgan, Ross S.; Maurin, Guillaume; Lima, Enrique; Ibarra, Ilich A.

doi:10.1016/j.isci.2020.101156

Cited by 28 publications

(21 citation statements)

References 78 publications

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“…MFM-300(Sc), isostructural to the −Al and −In, −Fe, −V, and −Cr analogues, comprises of [ScO 4 (OH) 2 ] nodes bridged by 3,3′,5,5′-biphenyl-tetracarboxylate (BPTC) linkers to form a wine-track channel of 8.1 Å with μ-OH groups pointing toward the pore (Figures and S1). MFM-300(Sc) has demonstrated promising adsorption performance toward a series of molecules, for example, H 2 , CO 2 , CH 4 , SO 2 , H 2 S, I 2 , H 2 O, and ferulate combined with a high stability in diverse media.…”

Section: Introductionmentioning

confidence: 99%

Ammonia Capture via an Unconventional Reversible Guest-Induced Metal-Linker Bond Dynamics in a Highly Stable Metal–Organic Framework

et al. 2021

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An unprecedented reversible guest-induced metallinker bond rearrangement in metal−organic framework (MOFs) was revealed by quantum-calculations and DRIFT experiments. As a showcase, the prototypical MOF-type MFM-300(Sc) was demonstrated to undergo a substantial Sc-carboxylate bond dynamics upon ammonia adsorption to enable a strong metal− guest binding mode, a key feature to ensure a highly efficient capture of this toxic molecule. Decisively, we evidenced this adsorption mechanism to be fully reversible, preserving the ammonia capture performance and structure integrity over multiple cycles. Such an unconventional mechanism in MOFs can open up new avenues to design novel materials for an efficient capture of highly corrosive molecules.

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Section: Introductionmentioning

confidence: 99%

Ammonia Capture via an Unconventional Reversible Guest-Induced Metal-Linker Bond Dynamics in a Highly Stable Metal–Organic Framework

et al. 2021

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“…[ 61 ] In addition, Sc‐based MOF, MFM‐300, could penetrate across epidermis and reach dermis. [ 62 ] Considering that the positively charged nanoparticles have higher penetration efficiency compared with negatively charged nanoparticles, the exposure of MOFs with positive charge may induce epidermal penetration, leading to internal exposure risks.…”

Section: Possible Exposure Routes Of Mofs To Humanmentioning

confidence: 99%

Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal–Organic Frameworks

Fang

Yan

2022

Small Science

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Reticular chemistry has become a powerful tool for scientists to design crystalline porous materials with different fundamental units. [1] Over the past decades, porous materials have gained great attention due to their outstanding performance and wide applications. Among various porous materials, the combination of metal nodes and organic linkers by coordination bonds creates new hybrid porous materials called metal-organic frameworks (MOFs) and opens a new window in the design of porous materials.Since the first report on MOFs by Yaghi's group in 1995, [2] more than 100 000 kinds of MOFs have been synthesized according to the Cambridge Structural Database (CSD). The unique characteristics, including tunable porosity, customized chemical composition, large specific surface area, and easy functionalization, make MOFs promising candidates for numerous applications in diverse fields such as gas storage and separation, catalysis, sensing, adsorption, energy, and biomedical sciences. [3] In addition, the large-scale production and commercialization of MOFs began from 2016. [4] For instance, the commercial MOF adsorbent for storage of 1-methylcyclopropene to ripen vegetables and fruits was driven to the market. [5] The Numat's ION-X gas cylinder was designed based on the MOF adsorbent to store hazardous gases for semiconductor industry, showing significant advantages over traditional adsorbents. [3a] Apart from the commercialization in gas storage, the MOF-303-based apparatus has been used to collect water in the desert. [6] Despite the advantages of MOFs, the wide application of MOFs has led to environmental health risks. The accidental release of MOF particles into the environment from their bulk-products is inevitable during the lifecycle of MOFs. The deposition, decomposition, and distribution of released MOFs in environmental media could result in the exposure to humans and other organisms, inducing various biological effects. In addition, the intentional administration of MOFs in biomedicine (such as bioimaging, drug delivery system) also leads to the exposure risks to humans. Under these circumstances, the environmental health risks of MOFs are unavoidable.The toxicity of MOFs plays an important role in their health risk assessment. Compared with in vivo and ex vivo toxicity assessments, in vitro toxicity evaluation based on cell culture is low cost, fast, and high throughput, making it an ideal model in toxicity research. As the basic unit in organism, cells play an important role in life activity. The toxic effects on cells would affect their function and therefore induce significant response

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“…NOTT-400 preserves the antioxidant pharmacological effects of ferulate and improves the bio-preservation of dermal skin fibroblasts during the drug-release process. 69…”

Section: Third Stage: Metal–organic Frameworkmentioning

confidence: 99%