Controlled Trial of A.B.O.B. in Measles, Chicken-pox, and Mumps

Curwen, M. P.; Emond, R. T. D.; McKendrick, Greer

doi:10.1136/bmj.1.5325.236

Cited by 5 publications

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“…Among the antiviral agents which have been introduced during recent years, the biguanide derivative Nl,Nl-anhydrobis(,8-hydroxyethyl)biguanide hydrochloride (ABOB) has been investigated in the treatment of various human virus infections (1, 2, 3,8,19) and has been claimed to be clinically effective in the chemoprophylaxis of influenza virus infections (4, 16). Additional biguanides have also been tested in tissue cultures (7), although no evidence has been presented regarding the activity of these compounds in vivo.…”

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Chemoprophylactic Effect of Phenylethylbiguanide (Dbi) on Influenza A2 and Influenza B Virus Infections in Diabetic Patients

Berglund

Jakobson

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et al. 1970

Journal of Internal Medicine

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Abstract. The chemoprophylactic effect of phenylethylbiguanide (DBI) has been studied in 183 adult diabetics attending a diabetic out‐patient department during the outbreak of an influenza A2 and influenza B virus epidemic in Helsinki in 1965. Paired serum specimens were obtained from 53 patients in the DBI group and 130 in the non‐DBI group with an interval of four weeks to two months for the titration of CF and HI antibody of influenza A2 and B. Symptoms and signs of acute respiratory disease (ARD) which occurred between the samplings or prior to the first sampling were recorded. The rate of total ARD was slightly, and the rate of ARD with symptoms of typical influenza significantly, lower in the DBI group than in the non‐DBI group. The rate of ARD caused by influenza A2 was 8% in the DBI group and 18% in the non‐DBI group, the difference between the two groups being statistically significant, whereas no significant differences were observed in the rate of ARD caused by influenza B virus. Influenza A2 virus caused 4/19 (21%) of ARD in the DBI group and 23/60 (38%) of ARD in the non‐DBI group.

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