1971
DOI: 10.1016/s0140-6736(71)90268-6
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Controlled Trial of Azathioprine in Crohn's Disease

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Cited by 294 publications
(122 citation statements)
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“…Crohn's disease (CD), 3 but the mystery remains unsolved. The problem is that CD affects young adults, and there is no satisfactory therapy.…”
Section: E Fforts Have Been Made To Elucidate the Pathogenesis Ofmentioning
confidence: 99%
See 1 more Smart Citation
“…Crohn's disease (CD), 3 but the mystery remains unsolved. The problem is that CD affects young adults, and there is no satisfactory therapy.…”
Section: E Fforts Have Been Made To Elucidate the Pathogenesis Ofmentioning
confidence: 99%
“…Corticosteroids are the most commonly used, but they only relieve the symptoms, without improvement of endoscopically visible lesions (2). Azathioprine and other immunosuppressive medications are also used, but their effectiveness in inducing remission remains controversial, and their utility is limited because of their side effects (3). Recently, anti-TNF-␣ mAb has been shown to be useful in patients with steroid-unresponsive CD (4).…”
Section: E Fforts Have Been Made To Elucidate the Pathogenesis Ofmentioning
confidence: 99%
“…Some patients remain seriously ill with active disease after all therapeutic options have been exhausted [49][50][51]. Moreover, a distinct excessive mortality from CD exists in this group of patients [52][53][54][55].…”
Section: Crohn's Diseasementioning
confidence: 99%
“…More recently, studies have demonstrated that 6-thioguanine triphosphate (6-TGTP) inhibits Rac1 required for T-cell stimulation, resulting in T-cell apoptosis [Tiede et al 2003]. Kirsner and colleagues at the University of Chicago were amongst the first to show its efficacy in UC nearly 45 years ago [Bowen et al 1966], and it was subsequently shown to be beneficial in CD as well [Present et al 1980;Willoughby et al 1971].…”
mentioning
confidence: 99%