Controlled trial of Iodosorb in chronic venous ulcers.

Ormiston, M. C.; Seymour, Matthew; Venn, G E; Cohen, Rubin I.; Fox, J A

doi:10.1136/bmj.291.6491.308

Cited by 81 publications

(39 citation statements)

References 2 publications

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“…The presence of bacterial contamination appears to have little significance in healing of the ulcer. We found no relation between the presence of infection at the initiation of treatment and healing of the same ulcerated lesion; however, we noted microbiological changes during the healing process of the injury, which coincides with views expressed by Ormiston et al 32 It seems logical to recommend the identification of the initial area of the venous ulcer when comparing different therapeutic approaches. This determination must be made by planimetry, which is the correct method for measuring the lesion.…”

Section: Discussionsupporting

confidence: 73%

Influence of Aspirin Therapy in the Ulcer Associated With Chronic Venous Insufficiency

Solá

Antonio

Fajardo

et al. 2012

Annals of Vascular Surgery

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Background: To determine the effect of aspirin on ulcer healing rate in patients with chronic venous insufficiency, and to establish prognostic factors that influence ulcer evolution. Methods: Between 2001 and 2005, 78 patients with ulcerated lesions of diameter >2 cm and associated with chronic venous insufficiency were evaluated in our hospital. Of these, 51 patients (22 men, 29 women) with mean age of 60 years (range: 36e86) were included in a prospective randomized trial with a parallel control group. The treatment group received 300 mg of aspirin and the control group received no drug treatment; in both groups, healing was associated with standard compression therapy. During follow-up, held weekly in a blinded fashion, there was ulcer healing as well as cases of recurrence. Results were analyzed by intention-to-treat approach. Cure rate was estimated using KaplaneMeir survival analysis, and the influence of prognostic factors was analyzed by applying the Cox proportional hazards model. Results: In the presence of gradual compression therapy, healing occurred more rapidly in patients receiving aspirin versus the control subjects (12 weeks in the treated group vs. 22 weeks in the control group), with a 46% reduction in healing time. The main prognostic factor was estimated initial area of injury (P ¼ 0.032). Age, sex, systemic therapy, and infection showed little relevance to evolution. Conclusions: The administration of aspirin daily dose of 300 mg shortens the healing time of ulcerated lesions in the chronic venous insufficiency (CVI). The main prognostic factor for healing of venous ulcerated lesions is the initial surface area of the ulcer.

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Section: Discussionsupporting

confidence: 73%

Influence of Aspirin Therapy in the Ulcer Associated With Chronic Venous Insufficiency

Solá

Antonio

Fajardo

et al. 2012

Annals of Vascular Surgery

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“…The danger of applying too high a pressure, particularly in the absence of arterial pulses, has been reported recently. 4 Other studies reported that up to one quarter of the initial pressure under adhesive plaster bandages dissipated within 30 minutes, and three quarters of the pressure under a single elastic bandage dissipated within eight hours." 12 The four layer bandage seems to be unique in producing the necessary compression to prevent capillary transudation and in sustaining it over a full week.…”

Section: Discussionmentioning

confidence: 99%

Sustained compression and healing of chronic venous ulcers.

Blair

Wright²,

Backhouse³

et al. 1988

BMJ

330

144

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“…Ormiston and associates122 evaluated a cadexomer iodine dressing in the treatment of 61 patients with venous leg ulcers. The main outcomes of the study focused on wound closure; odor was reported as a secondary outcome.…”

Section: Efficacy Of Various Treatments On Wound Odormentioning

confidence: 99%

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

Akhmetova

Saliev

Allan

et al. 2016

Journal of Wound, Ostomy &Amp; Continence Nursing

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The process of wound healing is often accompanied by bacterial infection or critical colonization, resulting in protracted inflammation, delayed reepithelization, and production of pungent odors. The malodor produced by these wounds may lower health-related quality of life and produce psychological discomfort and social isolation. Current management focuses on reducing bacterial activity within the wound site and absorbing malodorous gases. For example, charcoal-based materials have been incorporated into dressing for direct adsorption of the responsible gases. In addition, multiple topical agents, including silver, iodine, honey, sugar, and essential oils, have been suggested for incorporation into dressings in an attempt to control the underlying bacterial infection. This review describes options for controlling malodor in chronic wounds, the benefits and drawbacks of each topical agent, and their mode of action. We also discuss the use of subjective odor evaluation techniques to assess the efficacy of odor-controlling therapies. The perspectives of employing novel biomaterials and technologies for wound odor management are also presented.

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Controlled trial of Iodosorb in chronic venous ulcers.

Cited by 81 publications

References 2 publications

Influence of Aspirin Therapy in the Ulcer Associated With Chronic Venous Insufficiency

Influence of Aspirin Therapy in the Ulcer Associated With Chronic Venous Insufficiency

Sustained compression and healing of chronic venous ulcers.

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

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