Controlled trial of Iodosorb.

Abstract

resonance. The guidelines for magnetic resonance imaging in Britain laid down by the National Radiological Protection Board allow for studies during the second and third trimesters of pregnancy. Smith has reported his findings in 120 normal and abnormal pregnancies (Smith F W, presented at fourth annual meeting of Society of Magnetic Resonance in Medicine, 1985). After 26 weeks, gestation he found that the fetal head, brain, eyes, lungs, heart, liver, bladder, and limbs were routinely seen. In normal pregnancies uterine size correlated closely with birth weight. Myelination of the basal ganglia could be identified and followed from as early as 34 weeks. Studies of fetal subcutaneous fat thickness are readily carried out. Gross malformations such as hydrocephalus and hydronephrosis are easily recognised. Despite the current rather long imaging times compared with those of ultrasonic examination, these preliminary findings suggest that sufficiently good images are obtainable to allow fetal development to be studied without radiation hazard. In particular, the stage maturation of the central nervous system, liver size, and subcutaneous fat thickness allow better differentiation of the growth retarded fetus as opposed to the "genetically or physiologically" small fetus.

Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta‐analysis of comparative clinical trials

“…Nine RCTs across both VLU and PU indications identified a reduction in purulence and cellular debris after use 9‐12,15,16,25‐27 . Significant reductions in pus and cellular debris following 4 weeks of treatment with CIOD vs SOC were demonstrated in VLUs by Lindsay 10 ( P < .002) and Troeng 9 ( P < .005)—with significant reductions observed at also weeks 2 and 6 in the latter study ( P < .025/ P < .001).…”

“…Several studies involving participants with VLU, DFU, and PU reported complete wound healing following CIOD intervention. In VLUs, significantly more wounds were healed using CIOD compared to SOC across studies spanning 6 weeks, 26,29 8 weeks, 10,25 and 12 weeks 12,13 intervention. Likewise in PUs, significantly more healing events were reported in the CIOD group compared to SOC in an RCT by Moberg et al 16 Also, in an open controlled comparative study in DFU, more wounds in the CIOD group healed compared to the SOC comparison group (5/22 vs 2/19).…”

“…The dual mode of action of CIOD combines physical and antimicrobial attributes, which work together to address many of the barriers to healing found particularly in chronic wounds, namely excessive exudate, slough, and bioburden 7 . The cadexomer beads have been shown to absorb up to seven times their own weight in fluid, 8 resulting in effective exudate management in wounds 8‐13 . This physical absorption by the starch beads provides a further de‐sloughing action 8‐10,12‐16 removing debris, purulence, 11,16 and bacteria 17 from the wound into the dressing.…”

Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo

“…CI has long been used effectively in chronic wounds and is supported by many clinical studies demonstrating the removal of barriers to healing, such as microbial infection, slough/debris, and exudate . In addition, a recent meta‐analysis (Cochrane review) highlighted that CI generates higher healing rates than standard care in venous leg ulcers (VLUs) …”

“…[21][22][23] CI has long been used effectively in chronic wounds and is supported by many clinical studies demonstrating the removal of barriers to healing, such as microbial infection, 21,[24][25][26][27] slough/debris, 21,[28][29][30][31][32] and exudate. 21,24,27,28,31,33,34 In addition, a recent meta-analysis (Cochrane review) highlighted that CI generates higher healing rates than standard care in venous leg ulcers (VLUs). 35,36 CI has previously been demonstrated to be highly effective against mature biofilms in multiple in vitro models incorporating various conditions, such as low and high exudate, 37 clinically relevant media, 38 or clinically relevant substrates such as porcine tissue.…”