Controlled trial of low-dose heparin and sulfinpyrazone to prevent venous thromboembolism after operation on the hip.

Rogers, P.H.; Walsh, PN; Marder, Victor J.; Bosak, G C; Lachman, J W; Ritchie, William G. M.; Oppenheimer, L.; Sherry, Sol

doi:10.2106/00004623-197860060-00005

Cited by 51 publications

(12 citation statements)

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“…[1,2] This risk has been well documented by previous studies, [3–6] and guidelines have recommended mechanical and pharmacological prophylaxis for patients undergoing surgery for hip fracture. [7] To our knowledge, however, few investigators have concentrated on the preoperative prevalence of thrombosis in these high-risk patients, although the occurrence of preoperative deep vein thrombosis (DVT) was reported to occur in 9% to 62% of patients, even when they were receiving prophylaxis.…”

Section: Introductionmentioning

confidence: 93%

Can patients with femoral neck fracture benefit from preoperative thromboprophylaxis?

Dai

et al. 2017

Medicine

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Background:The effectiveness of preoperative thromboprophylaxis remains obscure in patients with femoral neck fracture. The purpose of the current study was to investigate whether these patients benefit from preoperative thromboprophylaxis.Methods:In this prospective, randomized controlled trial, a total of 80 patients with femoral neck fracture were randomly assigned to receive either rivaroxaban or conservative treatment before surgery. For all patients, color Doppler ultrasound of both lower extremities was performed immediately after admission. The primary efficacy outcome was venous thromboembolism (VTE) defined as deep vein thrombosis (DVT) or pulmonary embolism (PE). The primary safety outcome was major bleeding.Result:Compared with conservative treatment, rivaroxaban could significantly reduce the incidence of DVT from 19.5% (8/41) to 2.6% (1/39) (P = .016). Preoperatively, there were a total of 9 occurrences of DVT including 8 DVT in the conservative treatment group and 1 in the oral rivaroxaban group. All cases of DVT were asymptomatic, with 8 of them diagnosed as isolated muscular calf vein thromboses. There were no differences between the 2 groups in terms of the overall incidence of major bleeding.Conclusion:Thromboprophylaxis with rivaroxaban prior to surgery can effectively reduce the risk of preoperative DVT for patients with femoral neck fracture without increasing the risk of bleeding.

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Section: Introductionmentioning

confidence: 93%

Can patients with femoral neck fracture benefit from preoperative thromboprophylaxis?

Dai

et al. 2017

Medicine

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“…Bleeding from the gastrointestinal tract or genito-urinary tract has been reported as well as bleeding from the central nervous system (Sakai & Amstutz 1976, Salvati & Lachiewicz 1976, Rogers et al 1978. Mechanical prophylaxis against deep vein thrombosis has attracted less interest although it is a method which is easy to control and devoid of risk.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of prophylactic anticoagulant medication varies with the method used (Soreff et al 1975, Jennings et al 1976, Stamatakis et al 1978), and opinions are divided concerning its effect and relative safety (Coventry et al 1973, Hampson et al 1974, Sakai & Amstutz 1976, Rogers et al 1978, Moskovitz et al 1978.…”

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confidence: 99%

Mechanical Prophylaxis Against Deep Vein Thrombosis in Charnley Hip Arthroplasty

Sørensen

Jørgensen

1981

Acta Orthopaedica Scandinavica

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“…The risk of venous thromboembolism (VTE) in such patients is substantial, accounting for the second most frequent complication of surgery [3]. Randomized controlled trials have shown that, in the absence of VTE prophylaxis, total and proximal deep vein thrombosis (DVT) rates are approximately 50% and 27%, respectively [4][5][6][7][8], but with modern treatment strategies, the incidence can be reduced to 1.34% [9].…”

Section: Introductionmentioning

confidence: 99%

“…The rate of fatal PE after hip fracture surgery (HFS) has been reported to be 0.66% to 7.5% and appears to be higher than that associated with elective total hip arthroplasty (THA) or total knee arthroplasty (TKA) [11][12][13] or with non-orthopedic surgical procedures [14].…”

Section: Introductionmentioning

confidence: 99%

Venous thromboembolic prophylaxis for hip fractures

2010

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Patients with hip fractures are at very high risk for the development of venous thromboembolism (VTE). To provide an overview of cause, risk factors, current treatment strategies, and complications associated with VTE prophylaxis, we reviewed the most current, best available evidence on VTE prophylaxis for patients with hip fractures. We comprehensively reviewed the literature to assess the efficacy of VTE prophylaxis in patients with hip fractures, including the most recent published guidelines by national medical and surgical health organizations from the UK, USA, and Canada. Mechanical devices are effective in reducing the risk of VTE for hip fracture, but poor patient compliance is common and the devices are not recommended for sole VTE prophylaxis. Aspirin reduces the risk of VTE but does not provide optimal protection compared with other chemical agents; therefore, it is not recommended for sole VTE prophylaxis. Fondaparinux, warfarin, low-molecular-weight heparin, and unfractionated heparin reduce the risk of venographic deep vein thrombosis, but there is insufficient evidence that they reduce fatal pulmonary embolism or all-cause mortality. Fondaparinux is considered to be cost effective and more efficacious than low-molecular-weight heparin. At present, most major health organizations advocate at least 28 days of postoperative chemical prophylaxis. Chemical VTE prophylaxis should be administered to all patients with hip fractures unless contraindicated. Additional research is required to establish an agent that has a significant impact on fatal pulmonary embolism and all-cause mortality, without increasing bleeding complications, in this group of patients.

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Controlled trial of low-dose heparin and sulfinpyrazone to prevent venous thromboembolism after operation on the hip.

Cited by 51 publications

References 0 publications

Can patients with femoral neck fracture benefit from preoperative thromboprophylaxis?

Can patients with femoral neck fracture benefit from preoperative thromboprophylaxis?

Mechanical Prophylaxis Against Deep Vein Thrombosis in Charnley Hip Arthroplasty

Venous thromboembolic prophylaxis for hip fractures

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