Controlled Trial of Routine Administration of Platelet Concentrates in Cardiopulmonary Bypass Surgery

Simon, Toby L.; Akl, Bechara F.; Murphy, William G.

doi:10.1016/s0003-4975(10)60755-2

Cited by 114 publications

(43 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An alternative hemostatic approach to patients recently exposed to DAT could be transfusion of platelets. However, we do not argue that approach due to two reasons: first, previous studies have shown that prophylactic use of platelet transfusion does not change chest tube output [20], secondly, it has been shown that platelet transfusion in the perioperative period of CABG is associated with increased risk for serious adverse events [21]. When considering appropriate preoperative APT management for patients undergoing CABG, possibility for both excessive bleeding and adverse ischemic events should concomitantly be assessed and platelet function test results should inextricably be included into consideration [22].…”

Section: Limitations Of Studymentioning

confidence: 74%

Bleeding risk assessment using multiple electrode aggregometry in patients following coronary artery bypass surgery

Petričević

Biočina

Miličić

et al. 2012

J Thromb Thrombolysis

View full text Add to dashboard Cite

Section: Limitations Of Studymentioning

confidence: 74%

Bleeding risk assessment using multiple electrode aggregometry in patients following coronary artery bypass surgery

Petričević

Biočina

Miličić

et al. 2012

J Thromb Thrombolysis

View full text Add to dashboard Cite

“…Prophylactic platelet administration has also been shown to be of no benefit in reducing transfusion requirements in cardiac surgical patients [24]. Disorders of platelet activation and aggregation occur during cardiopulmonary bypass.…”

Section: Discussionmentioning

confidence: 99%

Limiting the Usage of Blood Products in Cardiovascular Surgery

1991

View full text Add to dashboard Cite

We studied the effect of the initiation of a five part program of blood component conservation on blood product utilization in patients undergoing major cardiovascular surgery. We encouraged physicians and nurses to adhere to a set of guidelines that would limit the exposure of these patients to complications associated with blood product administration. Through this effort the amounts of packed red cells, fresh frozen plasma, platelets, and cryoprecipitate used were markedly reduced. After the start of the conservation program, overall blood product usage was reduced 29% despite a 46% increase in the surgical caseload, and there was a 53% decrease in the amount of donor exposure (units of individual blood products administered) per patient. Surgery. 1991; 11(2): 213-217 Modern transfusion practice in cardiac surgery is directed toward keeping the number of administered blood bank products to a minimum. In some hospitals, over 90% of patients undergoing coronary artery bypass grafting (CABG) do not receive any blood products as part of a comprehensive blood conservation program [1]. We recently reevaluated our use of blood products and embarked on a program to reduce the amount of patient exposure to infectious agents such as HIV-1 and hepatitis viruses. This effort was based on the following maneuvers whenever possible: removal of 450 to 900 ml of the patient's blood prior to cardiopulmonary bypass with reinfusion after reversal of heparinization; reinfusion of all possible blood from the oxygenator at the conclusion of bypass; withholding the prophylactic administration of fresh frozen plasma (FFP), platelets, and cryoprecipitate until laboratory tests indicated specific coagulation deficits; acceptance of postoperative normovolemic anemia (hematocrit, 25-30%); and reinfusion of postoperative mediastinal drainage. We report here the results of a concerted effort in the operating room and ICU to use less blood products in patients undergoing a variety of cardiac surgical operations. PE Horowitz, CM Lorenzen, RD Rhydderch, Limiting the Usage of Blood Products in Cardiovascular MethodsWe studied the blood product utilization of all patients at our hospital who were undergoing CABG, single valve replacement or repair, multiple valve operations, reoperations for valve repair or replacement, closure of atrial septal defect in patients above and below 16 years of age, and ventriculoseptal defect closure. All patients undergoing these operations from February 1 to August 31, 1988, were placed in the control group (Group I). A second group of patients operated on from May 1 to October 31, 1989 (Group II), was studied after the introduction of a new set of procedures and guidelines governing blood product administration. Limiting The Usage of Blood Products in Cardiovascular SurgeryAnnals of Saudi Medicine, Vol 11 No. 2; 1991 The following conservation techniques were utilized whenever possible for the patients in Group II: 1. Withdrawal of 450 to 900 ml of the patient's blood from the sideport of an 8.5 F percut...

show abstract

“…An increase above this level is justified only in severe platelet dysfunction. Platelet concentrates should not be administered routinely in cardiac surgery because it has been associated with increase in multi-organ failure and death [43,44]. One therapeutic TC unit in an adult patient increases the platelet count by 10-20 x10 9 /l.…”

Section: Thrombocyte Concentrate (Tc)mentioning

confidence: 99%

Hemotherapy in Cardiac Surgery

Wágner¹

2012

Perioperative Considerations in Cardiac Surgery

View full text Add to dashboard Cite

Controlled Trial of Routine Administration of Platelet Concentrates in Cardiopulmonary Bypass Surgery

Cited by 114 publications

References 11 publications

Bleeding risk assessment using multiple electrode aggregometry in patients following coronary artery bypass surgery

Bleeding risk assessment using multiple electrode aggregometry in patients following coronary artery bypass surgery

Limiting the Usage of Blood Products in Cardiovascular Surgery

Hemotherapy in Cardiac Surgery

Contact Info

Product

Resources

About