2024
DOI: 10.1016/j.biopha.2024.116622
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Controlling autoimmune diabetes onset by targeting Protease-Activated Receptor 2

Gal Reches,
Lynn Khoon,
Narmeen Ghanayiem
et al.
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Cited by 2 publications
(2 citation statements)
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“…Complete Par2 deficiency in all lymphocytes provided mice with full protection against autoimmune destruction of β-cells, whereas the β-cell specific Par2 mutation accelerated the onset of autoimmune diabetes. These findings underscore the potential benefit of Par2 modulation in autoimmune conditions in general, particularly type I diabetes [ 29 ].…”
Section: Introductionmentioning
confidence: 90%
See 1 more Smart Citation
“…Complete Par2 deficiency in all lymphocytes provided mice with full protection against autoimmune destruction of β-cells, whereas the β-cell specific Par2 mutation accelerated the onset of autoimmune diabetes. These findings underscore the potential benefit of Par2 modulation in autoimmune conditions in general, particularly type I diabetes [ 29 ].…”
Section: Introductionmentioning
confidence: 90%
“…The outcomes of these genetic modifications were clear. Total Par2 deficiency in lymphocytes conferred complete protection against autoimmune β-cell destruction, while the β-cell-specific Par2 mutation hastened the onset of autoimmune diabetes [ 29 ].…”
Section: Introductionmentioning
confidence: 99%