2013
DOI: 10.1074/jbc.r113.479808
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Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

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Cited by 322 publications
(295 citation statements)
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“…Cholesterol synthesis is controlled at numerous stages (45). DHCR7 inhabits a special place in the pathway, as the gateway to both cholesterol and vitamin D production.…”
Section: Discussionmentioning
confidence: 99%
“…Cholesterol synthesis is controlled at numerous stages (45). DHCR7 inhabits a special place in the pathway, as the gateway to both cholesterol and vitamin D production.…”
Section: Discussionmentioning
confidence: 99%
“…How these later enzymes are regulated is largely unexplored, but there is growing evidence that some of them serve as flux-controlling points (Sharpe and Brown, 2013). In renal cancer cells, for example, another enzyme of the mevalonate pathway, squalene monooxygenase (SM), which converts squalene to squalene-2,3-epoxide (Figure 1), has been proposed as a second rate-limiting enzyme in cholesterol synthesis, and may contribute to renal cancer development (Gonzalez et al, 1979).…”
Section: Cancer-related Regulators Of Cholesterol Metabolismmentioning
confidence: 99%
“…The lanosterol-to-cholesterol pathway is also complex, involving 19 enzymatic reactions. Lanosterol is either diverted into the Bloch pathway, leading to cholesterol formation through desmosterol, or the Kandutsch-Russell pathway through 7-dehydrocholesterol [43]. Our study indicated that the distal post-squalene sterol metabolites lathosterol, desmosterol and 7-DHC were lower in GT3 patients compared to GT2.…”
Section: Discussionmentioning
confidence: 61%
“…However, the antiviral efficacy of statin monotherapy in HCV patients has proved to be insignificant [41][42]. Regulation of cholesterol synthesis also occurs at other stages in the pathway [43]. The post-squalene pathway distal to HMCoA-R is important in regulation of cholesterol synthesis, and the predominant location of these enzymes in the endoplasmic reticulum also allows for possible interaction with HCV.…”
Section: Discussionmentioning
confidence: 99%
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