The essay attempts to discuss the genesis and entrenchment of corruption in sub-Saharan Africa taking a holistic approach. By integrating the historical and international contexts of the problem, it links the origins and spread of corruption to the colonization of Africa, the lasting legacy of that colonization, and the actions and practices of international actors. A holistic approach, it is argued, is necessary if the vice is to be understood in its historical totality. This will not only offer a more encompassing explanation of corruption but also allow for the development of well rounded strategies for the alleviation of the problem.The paper concludes that corruption is a multifaceted, complex problem that requires a comprehensive approach that cuts across disciplines. Through such an approach the economic, social, legal, administrative and moral aspects of the problem can be targeted. The approach should also recognize the close linkages among these aspects of the problem and draw in the international dimension of the causes of the problem. While acknowledging that efforts have been expended at the national and international levels to combat corruption, the paper argues that there is still a lot of room for improvement. Much more can be, and needs to be, done. Of particular importance is the need for political goodwill and commitment from governments, bureaucracies and international agencies. This is a necessary condition if the fight against corruption is to be both effective and sustainable.