Controlling drug release with additive manufacturing-based solutions

Machine learning predicts 3D printing performance of over 900 drug delivery systems

“…The drug dissolution behaviour of the formulations is affected by more than just the material components of the delivery system. The drug dissolution is influenced by design parameters of the formulation, such as weight and surface area-to-volume ratio [8,48], drug solubility [75];…”

“…Three-dimensional printing (3DP), or additive manufacturing, is a cutting-edge fabrication technology that involves the layer-by-layer fabrication of a 3D object based on a computeraided design (CAD) model [1][2][3][4][5][6]. Since the approval of the first 3D printed medicine, Spritam®, 3DP has been touted as the next disruptor of the pharmaceutical manufacturing industry [7,8]. Promising bespoke medicines with precise dosing, pharmaceutical 3DP may contribute to the clinical goal of precision medicines, allowing every individual to be able to receive the right dose at the right time [9][10][11][12][13][14].…”

3D printing of pharmaceutical oral solid dosage forms by fused deposition: The enhancement of printability using plasticised HPMCAS

“…Among other additive manufacturing methods, 3D printing (3DP) by fused deposition modelling (FDM) is one of the most commonly employed (Norman, Madurawe et al, 2017;Mathew, Pitzanti et al, 2020;Wallis, Al-Dulimi et al, 2020;Brambilla, Okafor-Muo et al, 2021;Katsiotis, Åhlén et al, 2021;Nashed, Lam et al, 2021;Patel, Khoder et al, 2021). FDM-3DP is highly anticipated to be the first 3DP technology deployed by pharmacies due to its relative user simplicity (Kipping, 2021).…”

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

“…Three-dimensional (3D) printing technology has become a popular additive manufacturing technology in recent years. It can be used to customize the release profile of tablets and has great application value in the development of shellac-based matrix tablets. , Interestingly, the application of nanotechnology may be the future development direction of the pharmaceutical field. By compressing nanoparticles and nanofibers into tablets, , shellac-based matrix tablets can be obtained with the advantages of a multihierarchical structure and easy customization.…”