Controlling Mass Transport in Microfluidic Devices

Kuo, Jason S.; Chiu, Daniel T.

doi:10.1146/annurev-anchem-061010-113926

Cited by 64 publications

(46 citation statements)

References 149 publications

(162 reference statements)

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“…However, we believe that bringing the fundamental principles of conventional methods into microfluidic instruments has more potential for such applications. For example, the principles used in conventional methods, including the use of lipophilic/amphipathic molecules, electroporation and combination with liposomes [123], can be combined with the advantages of a microfluidic system such as accurate control of mass transfer [127]. Unfortunately, there have been barely any major breakthroughs in this direction.…”

Section: Discussion and Outlookmentioning

confidence: 99%

Microfluidics‐based on‐a‐chip systems for isolating and analysing extracellular vesicles

Guo

Tao

Dawn

2018

J of Extracellular Vesicle

150

111

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Extracellular vesicles (EVs), which can be found in almost all body fluids, consist of a lipid bilayer enclosing proteins and nucleic acids from their cells of origin. EVs can transport their cargo to target cells and have therefore emerged as key players in intercellular communication. Their potential as either diagnostic and prognostic biomarkers or therapeutic drug delivery systems (DDSs) has generated considerable interest in recent years. However, conventional methods used to study EVs still have significant limitations including the time-consuming and low throughput techniques required, while at the same time the demand for better research tools is getting stronger and stronger. In the past few years, microfluidics-based technologies have gradually emerged and have come to play an essential role in the isolation, detection and analysis of EVs. Such technologies have several advantages, including low cost, low sample volumes, high throughput and precision. This review summarizes recent advances in microfluidics-based technologies, compares conventional and microfluidics-based technologies, and includes a brief survey of recent progress towards integrated “on-a-chip” systems. In addition, this review also discusses the potential clinical applications of “on-a-chip” systems, including both “liquid biopsies” for personalized medicine and DDS devices for precision medicine, and then anticipates the possible future participation of cloud-based portable disease diagnosis and monitoring systems, possibly with the participation of artificial intelligence (AI).

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Section: Discussion and Outlookmentioning

confidence: 99%

Microfluidics‐based on‐a‐chip systems for isolating and analysing extracellular vesicles

Guo

Tao

Dawn

2018

J of Extracellular Vesicle

150

111

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“…2. 3) [11]. The diffusion time, due to the Brownian's motion, is inversely related to the diffusion coefficient (D) of the molecule while the convection time is directly linked to the flow velocity (V).…”

Section: Peclet Number: P Ementioning

confidence: 99%

Basics of Micro/Nano Fluidics and Biology

Français

Madec

Dumas

et al. 2019

Engineering of Micro/Nano Biosystems

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Mastering the basics of theoretical and experimental aspects of fluidics and biology is an obvious requirement for the design and evaluation of micro/nano biosystems. This chapter provides a review of the phyics of micro/nano fluidics systems as well as basics of biochemistry and biological functions. It also gives detailed information on common experimental techniques used to characterize fluidic and biological systems as well as tyical examples of application.

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“…However, owing to the small length scales, often only a laminar flow profile is observed in microchannels (Re < 100). [17][18][19] This means that mixing is achieved by diffusion of molecules from one lamella to a neighboring one. The characteristic mixing time (tm) can be calculated by the Einstein-Smoluchovski equation:…”

Section: Mass Transport Phenomenamentioning

confidence: 99%

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

Noël

Hessel

2015

Topics in Organometallic Chemistry

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Flow chemistry is typically used to enable challenging reactions which are difficult to carry out in conventional batch equipment. Consequently, the use of continuous-flow reactors for applications in organometallic and organic chemistry has witnessed a spectacular increase in interest from the chemistry community in the last decade. However, flow chemistry is more than just pumping reagents through a capillary and the engineering behind the observed phenomena can help to exploit the technology's full potential. Here, we give an overview of the most important engineering aspects associated with flow chemistry. This includes a discussion of mass-, heat-, and photon-transport phenomena which are relevant to carry out chemical reactions in a microreactor. Next, determination of intrinsic kinetics, automation of chemical processes, solids handling and multistep reaction sequences in flow are discussed. Safety is one of the main drivers to implement continuous-flow microreactor technology in an existing process and a brief overview is given here as well. Finally, the scale-up potential of microreactor technology is reviewed.

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Controlling Mass Transport in Microfluidic Devices

Cited by 64 publications

References 149 publications

Microfluidics‐based on‐a‐chip systems for isolating and analysing extracellular vesicles

Microfluidics‐based on‐a‐chip systems for isolating and analysing extracellular vesicles

Basics of Micro/Nano Fluidics and Biology

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

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