Controlling morphology of peptide‐based soft structures by covalent modifications

Gour, Nidhi; Barman, Apurba Kr.; Verma, Sandeep

doi:10.1002/psc.2411

Cited by 28 publications

(26 citation statements)

References 57 publications

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“…Previously, a number of strategies including pH mediated control 21, 22 , solvent mediated control 23 , covalent modifications 24 , vapour deposition 25, 26 , temperature 27 , surface 28, 29 , relative humidity 30 , symmetry 31 and magnetite coating on the surface of nanotubes 32 have been employed to regulate the architecture of diphenylalanine self-assemblies. But studies with fairly high magnetic fields have not yielded the level of response as expected, though a response was forced, at a magnetic field range of 12 T or more 33 .…”

Section: Introductionmentioning

confidence: 99%

Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields

Pandey

Saikia

Sasidharan

et al. 2017

Sci Rep

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Peptide based nano-assemblies with their self-organizing ability has shown lot of promise due to their high degree of thermal and chemical stability, for biomaterial fabrication. Developing an effective way to control the organization of these structures is important for fabricating application-oriented materials at the molecular level. The present study reports the impact of electric and magnetic field-mediated perturbation of the self-assembly phenomenon, upon the chemical and structural properties of diphenylalanine assembly. Our studies show that, electric field effectively arrests aggregation and self-assembly formation, while the molecule is allowed to anneal in the presence of applied electric fields of varying magnitudes, both AC and DC. The electric field exposure also modulated the morphology of the self-assembled structures without affecting the overall chemical constitution of the material. Our results on the modulatory effect of the electric field are in good agreement with theoretical studies based on molecular dynamics reported earlier on amyloid forming molecular systems. Furthermore, we demonstrate that the self-assemblies formed post electric-field exposure, showed difference in their crystal habit. Modulation of nano-level architecture of peptide based model systems with external stimulus, points to a potentially rewarding strategy to re-work proven nano-materials to expand their application spectrum.

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Section: Introductionmentioning

confidence: 99%

Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields

Pandey

Saikia

Sasidharan

et al. 2017

Sci Rep

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“…10 Other key properties of the dipeptide nanostructures include intrinsic ferro- 11 and piezoelectricity 12 as well as high mechanical 13 and thermal stability. 14 It has been shown that the morphologies of the assemblies can be varied through chemical modification of the FF peptide 15,16 or through control of the external conditions during the self-assembly process. 17 The most common method of preparation of crystalline FF for such applications is the dilution of a stock solution of FF in hexafluoroisopropanol (HFIP) (typically 100 g/l, 321 mM) at a ratio of 1:50 in water, producing a fine suspension of visible crystallites within seconds.…”

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confidence: 99%

Expanding the Solvent Chemical Space for Self-Assembly of Dipeptide Nanostructures

Chirgadze²,

et al. 2014

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Nanostructures composed of short, noncyclic peptides represent a growing field of research in nanotechnology due to their ease of production, often remarkable material properties, and biocompatibility. Such structures have so far been almost exclusively obtained through self-assembly from aqueous solution, and their morphologies are determined by the interactions between building blocks as well as interactions between building blocks and water. Using the diphenylalanine system, we demonstrate here that, in order to achieve structural and morphological control, a change in the solvent environment represents a simple and convenient alternative strategy to the chemical modification of the building blocks. Diphenylalanine (FF) is a dipeptide capable of self-assembly in aqueous solution into needle-like hollow micro- and nanocrystals with continuous nanoscale channels that possess advantageous properties such as high stiffness and piezoelectricity and have so emerged as attractive candidates for functional nanomaterials. We investigate systematically the solubility of diphenylalanine in a range of organic solvents and probe the role of the solvent in the kinetics of self-assembly and the structures of the final materials. Finally, we report the crystal structure of the FF peptide in microcrystalline form grown from MeOH solution at 1 Å resolution and discuss the structural changes relative to the conventional materials self-assembled in aqueous solution. These findings provide a significant expansion of the structures and morphologies that are accessible through FF self-assembly for existing and future nanotechnological applications of this peptide. Solvent mediation of molecular recognition and self-association processes represents an important route to the design of new supramolecular architectures deriving their functionality from the nanoscale ordering of their components.

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“…[10] In order to improve its aqueous solubility, mannose residues were covalently attached to yield constructs 8-10 (Scheme 2). [31] Interestingly, mannose conjugation leads to a morphology switch from tubular to fibrillar and spherical structures.…”

Section: Carbohydrate Conjugationmentioning

confidence: 99%

Peptide-based Synthetic Design, Construction and Morphology of Soft Structures

Mondal

Barman²,

Verma³

2012

Chimia

Self Cite

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Peptide-based self-assembly offers a unique entry into the construction of soft structures with interesting material properties and functions. Aromatic amino acid-containing peptides are commonly employed as they exhibit high propensity to aggregate due to increased hydrophobic content, promotion of favorable secondary structures, planarity and the possibility of π-π interactions. Incorporation of covalent scaffolds, stimuli-responsive handles and carbohydrate moieties augment beneficial characteristics to the resulting peptide conjugates. These modifications were shown to enforce self-association, elicit stimuli response and achieve improved hydrophilic properties, to name but a few.

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Controlling morphology of peptide‐based soft structures by covalent modifications

Cited by 28 publications

References 57 publications

Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields

Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields

Expanding the Solvent Chemical Space for Self-Assembly of Dipeptide Nanostructures

Peptide-based Synthetic Design, Construction and Morphology of Soft Structures

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