Controlling nucleation in giant liposomes

Tester, Chantel C.; Whittaker, Michael; Joester, Derk

doi:10.1039/c4cc01457j

Cited by 50 publications

(72 citation statements)

References 33 publications

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“…14,16 Systematic studies of the precipitation of CaCO 3 and CaSO 4 have suggested that there are various mechanisms by which confinement can affect the kinetics of the precipitation. The considerable stabilization observed for amorphous calcium carbonate (ACC) within unilamellar vesicles 17,19 has been attributed to the exclusion of nucleating impurities from these small volumes. An alternative mechanism was proposed to explain the observed stabilization of ACC with respect to calcite in the crossed-cylinder apparatus.…”

Section: Discussionmentioning

confidence: 99%

“…Recent work has provided strong evidence, however, that confinement can also have significant effects on the precipitation of compounds such as calcium carbonate 13 and calcium sulfate, sometimes at surprisingly large length scales. [14][15][16][17][18][19] In this article, we investigate the effects of confinement on the precipitation of calcium phosphate (CaP), the principal inorganic component of bones and teeth. Confinement plays a key role in the formation of bone, which begins with the growth of ultrathin platelets of nonstoichiometric carbonated hydroxyapatite (HAP) within gaps in the collagen fibrils.…”

Section: Introductionmentioning

confidence: 99%

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Confinement Increases the Lifetimes of Hydroxyapatite Precursors

2014

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The mineral component of bone is a carbonated, non-stoichiometric hydroxyapatite (calcium phosphate) that forms in nanometer confinement within collagen fibrils, the principal organic constituent of bone. We here employ a model system to study the effect of confinement on hydroxyapatite precipitation from solution under physiological conditions. In common with earlier studies of calcium carbonate and calcium sulfate precipitation, we find that confinement significantly prolongs the lifetime of metastable phases, here amorphous calcium phosphate (ACP) and octacalcium phosphate (OCP). The effect occurs at surprisingly large separations of up to 1 m, and at 0.2 m the lifetime of ACP is extended by at least an order of magnitude. The soluble additive poly(aspartic acid), which in bulk stabilizes ACP, appears to act synergistically with confinement to give a greatly enhanced stability of ACP. The reason for the extended lifetime appears to be different from that found with CaCO 3 and CaSO 4 , and underscores both the variety of mechanisms whereby 2 confinement affects the growth and transformation of solid phases, and the necessity to study a wide range of crystalline systems to build a full understanding of confinement effects. We suggest that in the case of ACP and OCP the extended lifetime of these metastable phases is chiefly due to a slower transport of ions between a dissolving metastable phase, and the more stable, growing phase. These results highlight the potential importance of confinement on biomineralisation processes.3

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Confinement Increases the Lifetimes of Hydroxyapatite Precursors

2014

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“…Scanning probe microscopy is of little use, for example, in examining crystallization pathways that involve aggregation or ordered assembly of molecular clusters [7] or post-nucleation particles [8,9] in bulk solutions. Similarly, nucleation events that occur within ScienceDirect organic matrices, such as globular phases of macromolecules [10], lipid vesicles [11,12], amelogenin [13], and collagen [14], cannot be accessed via scanned probe methods.…”

Section: Introductionmentioning

confidence: 98%

In-situ liquid phase TEM observations of nucleation and growth processes

Yoreo

2016

Progress in Crystal Growth and Characterization of Materials

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Nucleation and growth of crystals is a pervasive phenomenon in the synthesis of man-made materials, as well as mineral formation within geochemical and biological environments. Over the past two decades, numerous ex situ studies of crystallization have concluded that nucleation and growth pathways are more complex than envisioned within classical models. The recent development of in situ liquid phase TEM (LP-TEM) has led to new insights into such pathways by enabling direct, real-time observations of nucleation and growth events. Here we report results from LP-TEM studies of Au nanoparticle, CaCO3 and iron oxide formation. We show how these in situ data can be used to obtain direct evidence for the mechanisms underlying crystallization, as well as dynamic information that provides constraints on important kinetic and thermodynamic parameters not available through ex situ methods.

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“…Where the pore surface is wetted by the nucleus, nucleation rates should be enhanced over those on flat substrates for pore dimensions on the order of the critical nucleus size, because the curvature of the pore enables a larger fraction of the nucleus to be in contact with the substrate. However, dramatic effects on the stability of metastable phases within confined volumes that are orders of magnitude larger than the length scale expected for the critical nucleus have been reported for solutions confined between crossed cylinders (71,93) and in liposomes (72,94). [The latter may be representative of sea urchin embryos (95).]…”

Section: Effect Of Extrinsic Factors: Surfaces Impurities and Confimentioning

confidence: 99%

Crystallization by particle attachment in synthetic, biogenic, and geologic environments

Yoreo

Gilbert

Sommerdijk

et al. 2015

Science

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1,676

1,637

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Field and laboratory observations show that crystals commonly form by the addition and attachment of particles that range from multi-ion complexes to fully formed nanoparticles. The particles involved in these nonclassical pathways to crystallization are diverse, in contrast to classical models that consider only the addition of monomeric chemical species. We review progress toward understanding crystal growth by particle-attachment processes and show that multiple pathways result from the interplay of free-energy landscapes and reaction dynamics. Much remains unknown about the fundamental aspects, particularly the relationships between solution structure, interfacial forces, and particle motion. Developing a predictive description that connects molecular details to ensemble behavior will require revisiting long-standing interpretations of crystal formation in synthetic systems, biominerals, and patterns of mineralization in natural environments.

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Controlling nucleation in giant liposomes

Cited by 50 publications

References 33 publications

Confinement Increases the Lifetimes of Hydroxyapatite Precursors

Confinement Increases the Lifetimes of Hydroxyapatite Precursors

In-situ liquid phase TEM observations of nucleation and growth processes

Crystallization by particle attachment in synthetic, biogenic, and geologic environments

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