Controlling Nutritional Status Score Before Receiving Treatment as a Prognostic Indicator for Patients With Urothelial Cancer: An Exploration Evaluation Methods

Peng, Lei; Du, Chunxiao; Meng, Chunyang; Li, Jinze; You, Chengyu; Li, Xianhui; Zhao, Pan; Cao, Dehong; Li, Yunxiang

doi:10.3389/fonc.2021.702908

Cited by 7 publications

(6 citation statements)

References 50 publications

(84 reference statements)

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“…In a study of 94 patients with non-invasive BC, the CONUT score obtained before treatment was correlated with poor survival and recurrence ( 41 ). In another meta-analysis examining 4,044 patients with metastatic urothelial carcinoma, pretreatment CONUT score was correlated with poor survival ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Geriatric nutritional risk index and controller nutritional status score before metastatic first-line chemotherapy predict survival in patients over 70 years of age with metastatic bladder cancer

Balçık,

Demir,

Ilhan

et al. 2024

Front. Med.

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IntroductionSeveral prognostic factors have been identified in patients with metastatic bladder cancer (BC). As it is known, older adult patients are prone to nutritional deficiency. The knowledge about nutrition and impact on survival in older patients with metastatic bladder cancer is missing. It is necessary to specifically examine this population. Because timely interventions can make a positive impact on this patients population. This retrospective study aimed to evaluate the prognostic effect of the Geriatric Nutritional Risk Index (GNRI), Controller Nutritional Status (CONUT) score and Prognostic Nutritional Index (PNI) before first-line chemotherapy in the metastatic stage in patients with metastatic bladder cancer over 70.Participants and methodsPatients over 70 with pathologically confirmed denovo metastatic or recurrent metastatic bladder cancer were included in the study. Patients with infections diagnosed at the time of diagnosis, autoimmune diseases or history of steroid use were excluded. Since our population consists of a specific age group with a specific cancer, we found a new cut-off value by performing ROC analysis to ensure optimal sensitivity and specificity in terms of progression. Low GNRI value was related with poor nutritional status. Low PNI value was related with poor nutritional status and high CONUT score was related with poor nutritional status. Factors predicting overall survival (OS) and Progression-Free Survival (PFS) were assessed using both univariate and multivariate Cox proportional hazards analyses.Results106 patients were included in the study and the average age was 75.5 years. In the GNRI-Low group, PFS was significantly shorter than that in the GNRI-High group [HR (95% CI) = 57.1 (12.8–255.5), (p < 0.001)]. Among those with a low-CONUT score, PFS was found to be longer than that in the high-CONUT group [HR (95% CI) = 1.7 (1.0–3.0), (p = 0.039)]. The median PFS of the PNI-Low group wasn’t significantly shorter than that of the PNI-High group [HR (95% CI) = 1.8 (0.5–6.2), (p = 0.359)].ConclusionOur study suggests that the GNRI and CONUT scores are useful for predicting survival in patients over 70 years of age with BC.

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Section: Discussionmentioning

confidence: 99%

Geriatric nutritional risk index and controller nutritional status score before metastatic first-line chemotherapy predict survival in patients over 70 years of age with metastatic bladder cancer

Balçık,

Demir,

Ilhan

et al. 2024

Front. Med.

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“…conducted a meta-analysis that included 2601 patients, revealing a significant association between high CONUT score and poor prognosis in patients with colorectal cancer ( 10 ). A meta-analysis involving eight studies has demonstrated the correlation between high CONUT score and OS, cancer-specific survival, and RFS in patients with urothelial carcinoma who have undergone systematic treatment ( 34 ). A meta-analysis conducted by Zhang et al.…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis

Liu,

Zhou,

Zhou

et al. 2023

Front. Oncol.

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BackgroundBiliary tract cancer (BTC) is a malignancy associated with unfavorable outcomes. Advanced BTC patients have a propensity to experience compromised immune and nutritional status as a result of obstructive jaundice and biliary inflammation. Currently, there is a lack of consensus on the impact of the Controlling Nutritional Status (CONUT) score in the context of BTC prognosis. The purpose of this study is to conduct a meta-analysis on the association between CONUT and the prognosis of patients suffering from BTC.MethodsA defined search strategy was implemented to search the PubMed, Embase, and Web of Science databases for eligible studies published until March 2023, with a focus on overall survival (OS), relapse-free survival/recurrence-free survival(RFS), and relevant clinical characteristics. The prognostic potential of the CONUT score was evaluated using hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs).ResultsIn this meta-analysis, a total of 1409 patients from China and Japan were involved in 9 studies. The results indicated that the CONUT score was significantly correlated with worse OS (HR=2.13, 95% CI 1.61-2.82, P<0.0001) and RFS (HR=1.83, 95% CI 1.44–2.31, P<0.0001) in patients with BTC. And, the analysis showed that a high CONUT score was significantly associated with clinical characteristics such as jaundice (OR=1.60, 95% CI=1.14–2.25, P=0.006), poorly differentiated tumor (OR=1.43, 95% CI=1.03–1.99, P=0.03), pT3 and 4 stage of the tumor (OR=1.87, 95% CI=1.30–2.68, P=0.0007), and complications of Clavien-Dindo classification grade IIIa or higher (OR=1.79, 95% CI=1.03–3.12, P=0.04).ConclusionThis meta-analysis indicates that a high CONUT score can serve as a significant prognostic indicator for survival outcomes among patients diagnosed with BTC.

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“…One study included all urinary carcinoma, include renal cell carcinoma and testicular carcinoma [36]. The other two studies only focus on bladder carcinoma [37,38], ignoring the similarities in morphological structure and carcinoma biology of urinary transitional epithelium [39]. This similarity not only Forest plot and meta-analysis of the relationship between OS and SII…”

Section: Discussionmentioning

confidence: 99%

Preoperative Systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma

Zheng,

Peng,

Zhang

et al. 2023

Preprint

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Background The systemic immune-inflammation index (SII) is a cost-efficient indicator for carcinoma prognosis. However, its utility in urothelial carcinoma (UC) prognosis is disputed. This meta-analysis aims to assess SII's prognostic value in UC. Methods A thorough search of databases including PubMed, Web of Science, Embase, Cochrane Library, and Scopus, was conducted to find studies until January 11, 2023. Eligibility criteria were applied to select studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted from selected studies and compiled in a meta-analysis to gauge SII's association with survival outcomes such as overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), and progression-free survival (PFS). Results This analysis includes 19 studies with 11,348 UC patients. It was found that high SII significantly correlated with worse OS in UC patients (HR 1.430, 95% CI 1.237–1.653, P < 0.001). High SII values also linked with poorer CSS (HR 1.913, 95% CI 1.473–2.485, P < 0.001), RFS (HR 1.240, 95% CI 1.097–1.403, P < 0.001), and PFS (HR 1.844, 95% CI 1.488–2.284, P < 0.001) compared to low SII values. Subgroup analysis revealed SII's consistent prognostic value in UC across races, carcinoma types, sample sizes, and SII cut-off values, suggesting its potential as a prognostic indicator in UC patients. Conclusions Current evidence suggests SII as a promising, cost-efficient predictor in UC patients. This meta-analysis indicates SII's potential as a valuable prognostication tool in UC patients.

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Controlling Nutritional Status Score Before Receiving Treatment as a Prognostic Indicator for Patients With Urothelial Cancer: An Exploration Evaluation Methods

Cited by 7 publications

References 50 publications

Geriatric nutritional risk index and controller nutritional status score before metastatic first-line chemotherapy predict survival in patients over 70 years of age with metastatic bladder cancer

Geriatric nutritional risk index and controller nutritional status score before metastatic first-line chemotherapy predict survival in patients over 70 years of age with metastatic bladder cancer

Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis

Preoperative Systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma

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